Publications by authors named "Liyan Liu"

Ultrasonic reactors, widely applied in process intensification, face limitations in their industrial application due to a lack of theoretical support for their structural design and optimization, particularly concerning the uniformity of the cavitation zone. Addressing this gap, our study introduces a novel approach to design a multi-frequency octagonal ultrasonic reactor of capacity 9.5 L through numerical simulation and spectrum analysis.

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The optic nerve, comprising axons from retinal ganglion cells (RGCs), is a component of the central nervous system (CNS) that generally exhibits a limited regeneration capacity following injury in mature mammals, resulting in permanent vision loss. Here, we summarize recent advances in interventions targeting cell-intrinsic and cell-extrinsic mechanisms to enhance RGC axon regeneration. Additionally, we summarize strategies for guiding the reconnection of regenerating axons with brain visual targets, aiming to restore partial visual function.

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Background: Triple-negative breast cancer (TNBC) is a particularly aggressive type of breast cancer, known for its lack of effective treatments and unfavorable prognosis. The G protein-coupled estrogen receptor (GPER), a novel estrogen receptor, is linked to increased malignancy in various cancers. However, its involvement in the metabolic regulation of cancer-associated fibroblasts (CAFs), a key component in the tumour microenvironment, remains largely unexplored.

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Four cyclodextrins (CDs) including heptakis-O-(2-hydroxypropyl)-β-cyclodextrin (HP-β-CD), heptakis-O-(2,6-di-O-methyl)-β-cyclodextrin (DM-β-CD), β-cyclodextrin (β-CD), and γ-cyclodextrin (γ-CD) were evaluated for their ability to enhance the aqueous solubility of kaempferol (Kae). Phase solubility studies indicated that these four CDs can form 1:1 type complexes with Kae and that HP-β-CD demonstrated the most significant solubilizing effect on Kae. Among the CDs tested, HP-β-CD demonstrated the most significant solubilizing effect on Kae.

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Article Synopsis
  • The study aimed to optimize mycelial fermentation of the edible and medicinal fungus Inonotus hispidus by controlling the morphology of the inoculum.
  • It found that dispersed mycelial fragments performed better than aggregated clumps, leading to a shorter lag time and higher biomass yield in shake flask cultures.
  • The process was scaled up to a 100-L stirred tank, achieving significantly higher productivities and confirming that inoculum characteristics greatly influence fermentation outcomes.
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Purpose: The predictive value of the Systemic Immune-Inflammation Index (SII) on mortality in patients with sepsis-associated acute kidney injury (S-AKI) remains unclear. This study aims to investigate the predictive value of SII levels at the Intensive Care Unit (ICU) on the 28-day mortality of S-AKI patients.

Patients And Methods: S-AKI patients admitted to the ICU of Henan Provincial People's Hospital from January 1, 2023, to December 31, 2023.

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Background: Despite the significant impact of blindness on the affected individuals' quality of life, its burden has not been assessed according to temporal cause-specific changes in severity, impeding our ability to evaluate the impact of blindness on population health accurately. Therefore, we aimed to comprehensively quantify the changes in cause-specific blindness burden according to changes in disease severity for 18 causes of blindness.

Methods: For this cross-sectional population-based study, we derived data on prevalence, disability-adjusted life-years (DALYs), and population size between 1990 and 2019 from the Global Burden of Disease 2019 study.

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The hazards of polycyclic aromatic hydrocarbons (PAHs) on occupationally exposed population have been widely acknowledged. However, the occupational exposure risks associated their derivatives, methylated PAHs, remain poorly understood. This study conducted a screen of 126 PAHs and 6 oxidative stress biomarkers (OSBs) in paired serum-urine samples from 110 petrochemical workers to assess the risk associated with different PAHs exposure.

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Battery-type faradaic materials are considered a class of promising electrodes for capacitive deionization (CDI) due to their superior ability to store ions through redox reactions. However, the desalination potential of such electrode materials has not been fully explored subject to the accessibility, conductivity, stability, etc. Herein, embedded battery material Ag nanoparticles is designed in capsule-structural units composed of graphene and constructed freestanding composite electrodes for CDI.

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Gastric cancer has become a great challenge to human health in the world. We studied the expression and role of the circular RNA 0001438 (circ_0001438) with the aim of finding a biomarker to assess the prognosis of gastric cancer. Through a polymerase chain reaction, circ_0001438 expression in gastric cancer was detected.

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Mushroom polysaccharides have great anti-diabetes potential. The fruiting body of is rich in polysaccharides. However, few studies have been performed to date on -derived polysaccharides (TPs) in terms of anti-diabetes potential.

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Keratocystoma of the parotid gland is a rare benign salivary gland tumor. In 2022, the World Health Organization added keratocystoma to the classification of benign parotid tumors. Recently, our hospital encountered a case involving a 2-year-old child, making this the youngest patient reported to date.

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Background And Aims: Hyperhomocysteinemia (Hhcy) is a pathological condition marked by increased level of homocysteine and serves as an independent risk factor for a range of diseases including cardiovascular diseases and Alzheimer's disease. This study aims to examine alterations in Hhcy-related metabolites using serum metabolomics and unravel the distinct metabolic pathways involved, thereby offering a theoretical foundation for the early prevention and treatment of Hhcy.

Methods: Serum samples were collected from 56 individuals with Hhcy and 44 healthy controls.

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Article Synopsis
  • The study focuses on improving the precision of boom-type roadheaders in tunnel excavation, which is crucial for avoiding over and under excavation while increasing efficiency.
  • Traditional controllers struggle with complex cutting loads and measurement noise, prompting the authors to develop a comprehensive dynamic model of the cutting mechanism using the Lagrange method.
  • A novel dual extended state observer and a prescribed performance dynamic surface controller are introduced to enhance tracking performance while reducing computational demands, and their effectiveness is validated through experiments.
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Several studies have reported the relationship between α2C-adrenergic receptor (ADRA2C) and both neoplastic and non-neoplastic diseases. However, a comprehensive pan-cancer analysis is currently lacking. Utilizing the RNA sequencing (RNA-seq) datasets from The Cancer Genome Atlas (TCGA) database, the roles of ADRA2C in human pan-cancer were analyzed through a variety of bioinformatics approaches, including R programming language and single-cell sequencing data analysis, .

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Background: The possibility of association between SARS-CoV-2 genomic variation and immune evasion is not known among persons with Omicron variant SARS-CoV-2 infection.

Methods: In a retrospective cohort, using Poisson regression adjusting for sociodemographic variables and month of infection, we examined associations between individual non-lineage defining mutations and SARS-CoV-2 immunity status, defined as a) no prior recorded infection, b) not vaccinated but with at least one prior recorded infection, c) complete primary series vaccination, and/or d) primary series vaccination and ≥ 1 booster. We identified all non-synonymous single nucleotide polymorphisms (SNPs), insertions and deletions in SARS-CoV-2 genomes with ≥5% allelic frequency and population frequency of ≥5% and ≤95%.

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Hydrogen sulfide (HS), methanethiol (MeSH) and dimethylsulfide (DMS) are abundant sulfur gases with roles in biogeochemical cycling, chemotaxis and/or climate regulation. Catabolism of the marine osmolyte dimethylsulfoniopropionate (DMSP) is a major source of DMS and MeSH, but both also result from S-methylation of HS via MddA, an HS and MeSH S-methyltransferase whose gene is abundant in soil but scarce in marine environments. Here we identify the S-adenosine methionine (SAM)-dependent MeSH and HS S-methyltransferase 'MddH', which is widespread in diverse marine bacteria and some freshwater and soil bacteria.

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Hydrogel materials with hydrophilic cross-linked network exhibit remarkable super-wettability, enabling their widespread application in oily wastewater treatment. However, the single and loose structure lacks sufficient strength and porosity to resist long-term degradation. Herein, a structural synergistic molecular strategy was reported to introduce reinforcing phase structures and interfacial active sites into the polymer networks for long-term oil-water emulsion separation.

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The effect of anions on the positive electrospray ionization (ESI) of proteins in different strong acids with varying pH values from 3 to 1 is studied using high-pressure ESI. Reducing the pH from ∼2 to 1 caused a drastic shift in charge state from a high-charge-state distribution (HCSD) to a narrow low-charge-state distribution (LCSD). The shift in charge state was consistent with the circular dichroism result that showed a conformational change due to the "acid-induced folding" of proteins from an unfolding state to a compact molten globule state.

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Article Synopsis
  • A study was conducted to develop a nomogram to predict dropout intentions among Chinese medical students, as their attrition rate is notably high.
  • Over 4,500 medical undergraduates were surveyed to gather data on demographics, mental health, and work-related factors, identifying five key predictors including history of suicidal attempts and career choice regret.
  • The nomogram showed strong predictive ability with AUC values indicating good accuracy in both training and validation cohorts, suggesting it could be a useful tool for anticipating dropout risks.
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  • The study focuses on two specific gene functions, DsBBS1 and DsBBS2, related to the biosynthesis of bibenzyl compounds in a medicinal herb from Hainan Island, revealing important roles for these genes in this process.
  • Molecular docking simulations showed minor differences in structure between the two proteins, while expression analyses indicated the highest levels in the roots, highlighting their significance in biosynthesis.
  • The research determined that both genes can restore flavonoid content in transgenic plants, with DsBBS2 showing superior enzyme activity for resveratrol synthesis, providing new insights into the production of valuable compounds in the herb.
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As part of the central nervous system, the optic nerve, composed of axons from retinal ganglion cells (RGCs), generally fails to regenerate on its own when injured in adult mammals. An innovative approach to promoting optic nerve regeneration involves manipulating the interactions between amacrine cells (ACs) and RGCs. Here, we identified a unique AC subtype, dopaminergic ACs (DACs), that responded early after optic nerve crush by down-regulating neuronal activity and reducing retinal dopamine (DA) release.

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Background: Sugar phosphates (SPx) play important role in the metabolism of the organism. SPx such as glycerate 3-phosphate, fructose 6-phosphate and glucose 6-phosphate in biological samples have the poor stability, similar structure and low abundance, which make their separation and detection more challenging.

Method: UiO-66-NH and ZrO coated SiO(SBA-15) hard-core-shell adsorbents (UiO-66-NH@SBA-15 and ZrO@SBA-15) were synthesized, which were further used for dispersive solid-phase extraction for enriching the SPx in biological samples.

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Gastric cancer, a prevalent malady within the digestive tract, has a complex pathological mechanism and numerous patients. The regulation of gastric cancer process by long non-coding RNA (lncRNA) presented new prospects for the study of its molecular mechanism and the treatment of patients. The abnormal expressed genes in gastric cancer were screened by GSE193109 dataset.

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Enrichment and quantification of sugar phosphates (SPx) in biological samples were of great significance in biological medicine. In this work, a series of zirconium-based metal-organic frameworks (MOFs) with different degrees of defects, namely, HP-UiO-66-NH-, were synthesized using acetic acid as a modulator and were utilized as high-capacity adsorbents for the adsorption of SPx in biological samples. The results indicated that the addition of acetic acid altered the morphology of HP-UiO-66-NH-, with corresponding changes in pore size (3.

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