Insights into the Synergistic Catalytic Effect of TiO Supported V-W Oxides for Selective C-H Bond Oxidation of Cyclohexane to KA Oil.

It is urgent to develop an efficient and stable non-noble metal catalyst for selective C-H bond oxidation of cyclohexane. Herein, a series of V-W oxides supported on TiO catalysts (V-W/TiO) were fabricated. The V-W/TiO catalysts exhibited much higher catalytic activity for the selective oxidation of cyclohexane to KA oil, compared to that of V/TiO and W/TiO catalysts.

Metal-free synthesis of 1,1-dimethyl-2,2,2-trifluoroethyl substituted quinazolinones tandem radical cyclization of quinazolin-4(3)-ones with 3,3,3-trifluoro-2,2-dimethylpropanoic acid.

A metal-free (NH)SO-mediated decarboxylative trifluoromethylation reaction of alkenes with 3,3,3-trifluoro-2,2-dimethylpropionic acid has been proposed. This method offers a novel route for the direct synthesis of a series of CMeCF-containing quinazolinones from basic chemical raw materials. The reaction mechanism was studied by a radical trapping test and DFT methods, verifying an oxidation-triggered cascade process promoted by the CMeCF radicals.

A Mettl16/mA/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells.

Prenatal lethality associated with mouse knockout of Mettl16, a recently identified RNA N6-methyladenosine (mA) methyltransferase, has hampered characterization of the essential role of METTL16-mediated RNA mA modification in early embryonic development. Here, using cross-species single-cell RNA sequencing analysis, we found that during early embryonic development, METTL16 is more highly expressed in vertebrate hematopoietic stem and progenitor cells (HSPCs) than other methyltransferases. In Mettl16-deficient zebrafish, proliferation capacity of embryonic HSPCs is compromised due to G1/S cell cycle arrest, an effect whose rescue requires Mettl16 with intact methyltransferase activity.

Switching reactive oxygen species reactions derived from Mn-Pt anchored zeolite for selective catalytic ozonation.

Rationally switching reactive oxygen species (ROS) reactions in advanced oxidation processes (AOPs) is urgently needed to improve the adaptability and efficiency for the engineering application. Herein we synthesized bimetallic Mn-Pt catalysts based on zeolite to realize the switching of ROS reactions in catalytic ozonation for sustainable degradation of organic pollutants from water. The ROS reactions switched from singlet oxygen (O, 71.

(NH)SO promoted tandem radical cyclization of quinazolin-4(3)-ones with oxamic acids for the construction of fused quinazolinones under metal-free conditions.

A novel cascade radical addition/cyclization reaction of non-activated olefins and oxamic acids has been proposed. Under transition metal-free conditions, 36 quinazolinone derivatives containing an amide moiety were successfully synthesized, with the highest yield being 81%. This method involves the preparation of aminoacyl fused quinazolinone derivatives under mild conditions, offering advantages such as a high yield, a broad substrate compatibility, and a high atom economy.

Mn anchored zeolite molecular nest for enhanced catalytic ozonation of cephalexin.

The molecular nest structured catalysts have demonstrated better performance than the traditional supported catalysts. However, they have not been tried in antibiotics or other organic pollutants removal from water by advanced oxidation processes (AOPs). Here we synthesized Mn anchored zeolite molecular nest (Mn@ZN) for the catalytic ozonation of cephalexin (CLX), which is the widely used antibiotic and also a refractory pollutant in water.

Role of oxygen vacancy in spinel (FeCoNiCrMn)O high entropy oxides prepared via two different methods for the selective CH bond oxidation of p-chlorotoluene.

The selective CH bond oxidation of aromatic hydrocarbon is an interesting but challenging task, it is desirable to develop efficient heterogeneous non-noble metal catalyst for this reaction. Herein, two kinds of spinel (FeCoNiCrMn)O high entropy oxides were fabricated via two different methods (i.e.

Label-free fluorescence detection of alkaline phosphatase activity using a G-triplex based dumbbell-shaped probe.

Based on the fluorescence enhancement property of the G-triplex (G3)-Thioflavin T (ThT) complex, a fluorescent biosensor was successfully constructed for detection of ALP using a G3-based dumbbell-shaped probe (DP). In this work, calf intestinal ALP (CIP) can act on the 5'-terminal phosphate of DP, thereby regulating the subsequent DNA ligation reaction and enzyme cleavage of the DP nick. When the DP is digested by exonuclease, the released G3 can bind to ThT, resulting in enhanced fluorescence signal.

Multiwavelength High-Detectivity MoS Photodetectors with Schottky Contacts.

Photodetection is one of the vital functions for the multifunctional "More than Moore" (MtM) microchips urgently required by Internet of Things (IoT) and artificial intelligence (AI) applications. The further improvement of the performance of photodetectors faces various challenges, including materials, fabrication processes, and device structures. We demonstrate in this work MoS photodetectors with a nanoscale channel length and a back-gate device structure.

All electrospun fabrics based piezoelectric tactile sensor.

Tactile sensors have been widely used in the areas of health monitoring and intelligent human-machine interface. Flexible tactile sensors based on nanofiber mats made by electrospinning can meet the requirements of comfortability and breathability for wearing the body very well. Here, we developed a flexible and self-powered tactile sensor that was sandwich assembled by electrospun organic electrodes and a piezoelectric layer.

Copper-catalyzed C-N Bond Cleavage: Synthesis of N-sulfonylformamidines from N-(2-pyridinylmethyl)benzenesulfonamides.

Unlabelled: A broad range of N-sulfonyformamidines, widely used intermediates for drugs, were synthesized in moderate to excellent yields from 2-Pyridinemethanamine as N-source via Coppercatalyzed C-N cleavage. Firstly, N-(2-pyridinylmethyl)benzenesulfonamides were smoothly synthesized via 2-pyridinemethanamine and sulfonyl chlorides, then reacted with N,Ndimethylformamide dimethyl acetal to obtain the corresponding N-Sulfonylformamidines analogs, during which pyridin-2-ylmethyl and sulfonyl groups were essential for the C-N bond cleavage. The current work presents a valuable complementarity to the synthesis of N-sulfonyformamidines as 2- pyridinemethanamine can provide the N source and sulfonyl chloride,s which could be original materials.

Modified Gap Arthroplasty for Temporomandibular Joint Ankylosis Following Radiotherapy for Rhabdomyosarcoma: Report of an Unusual Case and Brief Literature Review.

Radiotherapy at the temporomandibular joint (TMJ) area often results in trismus, however, post radiation ankylosis is extremely rare and has not been previously reported in literature. Radiation is known to impact the vasculature of bony structures leading to bone necrosis with certain risk factors including surgical intervention, even teeth extraction, that could lead to osteoradionecrosis. Accordingly, gap arthroplasty for such case seemed rather challenging.

Robust Mg(Ca)Zr-Doped Acid-Base Bifunctional Mesoporous Silica and Their Applications in the Deacetalization-Knoevenagel Reaction.

A series of Mg(Ca)Zr-doped acid-base bifunctional mesoporous silica were synthesized to study the impact of the one-step or two-step impregnation method on material structure. The two-step method seems to be a better way to synthesize metal-based functionalized catalyst and their catalytic performance is investigated using deacetalization-Knoevenagel reaction as the probe reaction. The coexisting dual active sites and suitable designing routes endowed highly efficient (Conv.

Reliable resistive switching of epitaxial single crystalline cubic Y-HfO RRAMs with Si as bottom electrodes.

Previous studies have mainly focused on the resistive switching (RS) of amorphous or polycrystalline HfO-RRAM. The RS of single crystalline HfO films has been rarely reported. Yttrium doped HfO (YDH) thin films were fabricated and successful Y incorporation into HfO was confirmed by x-ray photoemission spectroscopy.

A silver catalyzed domino reaction of N-cyanamide alkenes and 1,3-dicarbonyls for the synthesis of quinazolinones.

A silver catalyzed domino reaction of N-cyanamide alkenes and 1,3-dicarbonyls including 1,3-diketones and ethyl acetoacetate has been developed for the facile synthesis of quinazolinones. In the presence of AgNO3/K2S2O8, the diketones could be converted to radicals and coupled with N-cyanamide alkenes to undergo a cyclization cascade for accessing quinazolinones. This method features mild reaction conditions, readily available starting materials, and valuable synthetic utility.

The construction of fluorescent heteropore covalent organic frameworks and their applications in spectroscopic and visual detection of trinitrophenol with high selectivity and sensitivity.

Two fluorescent covalent organic frameworks (COFs) which bear two kinds of pores with different sizes and shapes have been synthesized. The heteropore COFs exhibit spectroscopic and color changes to 2,4,6-trinitrophenol (TNP) with extremely high selectivity and sensitivity, which makes them excellent macroscopic chemosensors for the selective detection of TNP.

Synthesis and Antimicrobial Evaluation of Fire Ant Venom Alkaloid Based 2-Methyl-6-alkyl-Δ-piperideines.

The first synthesis of 2-methyl-6-pentadecyl-Δ-piperideine (1), a major alkaloid of the piperideine chemotype in fire ant venoms, and its analogues, 2-methyl-6-tetradecyl-Δ-piperideine (2) and 2-methyl-6-hexadecyl-Δ-piperideine (3), was achieved by a facile synthetic method starting with glutaric acid (4) and urea (5). Compound 1 showed in vitro antifungal activity against Cryptococcus neoformans and Candida albicans with IC values of 6.6 and 12.

HfO high-k solid-state incandescent devices: performance improvement using a Ti-embedded layer and observation of conductive paths as light-emitting sources.

Solid-state incandescent light-emission devices (SSI-LEDs) with a metal-oxide-semiconductor structure are promising candidates for future broadband light-emission devices. In this work, the electrical and light-emission features of SSI-LEDs based on HfO high-k thin films with or without the Ti-embedded layer on p-type silicon wafers have been studied. It turns out that the Ti-embedded layer can effectively reduce the turn-on voltage, thus improving the fluorescence efficiency of SSI-LEDs.

Hairpin-shaped DNA Templated Copper Nanoparticles for Fluorescence Detection of Adenosine Triphosphate Based on Ligation-mediated Exonuclease Cleavage.

DNA-templated copper nanoparticles (CuNPs) have recently received considerable interest as functional fluorescent probes for biochemical analysis. In this work, a novel ATP-dependent ligation reactions (ATP-DLR) based ATP assay strategy was proposed by using hairpin-shaped (HS) DNA templated CuNPs as a fluorescent probe. Nick sealing by T4 DNA ligase leads to the formation of intact HS DNA, which can resist the exonuclease cleavage and be taken as the template for CuNPs formation, resulting in strong fluorescence.

Let-7b overexpression leads to increased radiosensitivity of uveal melanoma cells.

Uveal melanoma (UM) is an intraocular malignant tumor in adults that is characterized by rapid progression and recurrence. Irradiation has become the primary therapy for UM patients who are not candidates for surgery. However, after large-dose fraction irradiation treatment, some patients undergo subsequent enucleation because of radiotherapy-related complications.

Synthesis and antifungal activity of natural product-based 6-alkyl-2,3,4,5-tetrahydropyridines.

Seven 6-alkyl-2,3,4,5-tetrahydropyridines (5a-5g) that mimic the natural piperideines that were recently identified in fire ant venom have been synthesized. Compounds 5c-5g with C-6 alkyl chain lengths from C14 to C18 showed varying degrees of antifungal activities, with 5e (6-hexadecyl-2,3,4,5-tetrahydropyridine) and 5f (6-heptadecyl-2,3,4,5-tetrahydropyridine) being the most active. Compound 5e exhibited minimum fungicidal concentrations of 3.

Potentiation of tumor radiotherapy by a radiation-inducible oncolytic and oncoapoptotic adenovirus in cervical cancer xenografts.

The p53 tumor suppressor pathway is impaired in more than 90% of cervical cancers and cancer-derived cell lines as a result of infection by human papillomavirus (HPV). The HPV E6 oncoprotein forms complexes with p53 and promotes its degradation via ubiquitin-dependent mechanism. In our study, we attempted to improve the clinical outcomes of this combined therapy by modifying the p53-targeted adenovirus to become radiation-responsive.

Radiation-inducible human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene therapy: a novel treatment for radioresistant uveal melanoma.

Uveal melanoma (UM) is one of the most therapy-resistant cancers. Radiotherapy is the preferred treatment for most cases of UM. However, some UM cells, such as the SP6.

Synthesis and application of tetraphosphane ligands in rhodium-catalyzed hydroformylation of terminal olefins: high regioselectivity at high temperature.

A new class of substituted tetraphosphane ligands has been developed and applied in the rhodium-catalyzed regioselective hydroformylation of terminal olefins. The high regioselectivity (linear selectivity is above 97 % for 1-octene and 1-hexene) at high temperature (140 degrees C) shown by these tetraphosphane ligands is remarkable considering the low regioselectivity commonly observed under similar reaction conditions when other bisphosphane analogues are used. The steric and electronic effects of substituents on the diarylphosphane moiety have also been examined.