In(OTf)-Only-Catalyzed Glycosylation via Activation of an Alkyne Appended with an Amide Auxiliary Group.

We herein present the development of a novel glycosylation protocol using glycosyl --(-methoxybenzamidoyl)-propynyl benzoates as donors, activated solely by a catalytic amount of In(OTf), eliminating the need for a Au(I) catalyst. This approach offers mild and orthogonal conditions, enabling glycosylation across a broad substrate scope and facilitating versatile one-pot strategies for glycan assembly. Mechanistic insights suggest that In(OTf) serves dual roles by being recruited to the auxiliary group through σ-coordination while activating the alkyne via π-interaction.

ROS fueled autonomous sol-gel-sol transitions for on-demand modulation of inflammation in osteoarthritis.

Osteoarthritis is the most prevalent form of arthritis, and a leading cause of pain and long-term disability. Dysregulation of redox homeostasis is a key feature in the pathological progression of osteoarthritis that amplifies the inflammatory response, aggravates synovitis and accelerates cartilage degradation. Herein, a hemin and chitosan-mediated antioxidant gel inducing ROS conversion (hc-MAGIC) was constructed to targeting oxidative stress for osteoarthritis treatment.

Nanoenzyme-Anchored Mitofactories Boost Mitochondrial Transplantation to Restore Locomotor Function after Paralysis Following Spinal Cord Injury.

Mitochondrial transplantation is a significant therapeutic approach for addressing mitochondrial dysfunction in patients with spinal cord injury (SCI), yet it is limited by rapid mitochondrial deactivation and low transfer efficiency. Here, high-quality mitochondria microfactories (HQ-Mitofactories) were constructed by anchoring Prussian blue nanoenzymes onto mesenchymal stem cells for effective mitochondrial transplantation to treat paralysis from SCI. Notably, the results demonstrated that HQ-Mitofactories could continuously produce vitality-boosting mitochondria with highly interconnected and elongated network structures under oxidative stress by scavenging excessive ROS.

Comparison of Accuracy in Mandible-First and Maxilla-First Approaches in Bimaxillary Orthognathic Surgery: A Meta-Analysis.

This meta-analysis compares the accuracy of mandible-first and maxilla-first approaches in bimaxillary orthognathic surgery to improve clinical decision-making. A systematic search was performed in PubMed, Web of Science, Embase, and Cochrane databases up to August 2024. The analysis included randomized controlled trials and cohort studies with a minimum of 10 patients.

High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China.

Food workers have frequent contact with unprocessed foods, but their carriage of Salmonella and potential influence on public health have not been comprehensively assessed. We investigated Salmonella carriage among food workers compared with non-food workers based on occupational health screening of 260,315 asymptomatic workers over an 8-year surveillance period in Yulin, China. We confirmed that healthy carriers serve as natural reservoirs for Salmonella, with higher carriage rates in food workers than non-food workers.

Development of Glycosylation Protocols Using Glycosyl -Phenylethynyl Pyrrole-2-carboxylates as Donors.

We herein introduce glycosyl -phenylethynyl pyrrole-2-carboxylates (PEPCs) as novel and highly efficient glycosyl donors. The unique inclusion of the pyrrole group, serving as both an electron-donating group and an -tethering scaffold, imparts exceptional shelf stability while retaining reactivity for glycosylation reactions. PEPC donors exhibit broad utility for both - and -glycosylation across a variety of substrates.

Angiosome-Guided Perfusion Decellularization of Fasciocutaneous Flaps.

Background:  Tissue engineering based on whole-organ perfusion decellularization has successfully generated small-animal organs, including the heart and limbs. Herein, we aimed to use angiosome-guided perfusion decellularization to develop an acellular fasciocutaneous flap matrix with an intact vascular network.

Methods:  Abdominal flaps of rats were harvested, and the vascular pedicle (iliac artery and vein) was dissected and injected with methylene blue to identify the angiosome region and determine the flap dimension for harvesting.

Influencing factors for pediatric eye disorders and health related quality of life: a cross-sectional study in Shanghai, China.

Background: Myopia, strabismus, and ptosis are common pediatric eye diseases, which have a negative impact on children and adolescents in terms of visual function, mental health, and health-related quality of life (HRQoL). Therefore, this study focused on those pediatric eye diseases by analyzing their risk factors and HRQoL for the comprehensive management of myopia, strabismus, and ptosis.

Methods: A total of 363 participants (2-18 years old) were included in this study for risk factors analysis of myopia, strabismus, and ptosis.

The research status and prospects of nanomaterials in wound healing: A scientometric study.

Nanotechnology and nanomaterials have swiftly influenced wound healing, propelling the development of wound-healing nanomaterials. Therefore, it's crucial to gather essential information about prominent researches in this domain. Moreover, identifying primary directions and related frontiers in wound healing and nanomaterials is paramount.

Detecting the effects of opencast mining on ecosystem services value in arid and semi-arid areas based on time-series remote sensing images and Google Earth Engine (GEE).

Ecosystem Services Value (ESV) are the various beneficial functions and products that natural ecosystems provide to humans, and are important indicators for evaluating ecosystem conditions and human well-being. Opencast mining is one of the human activities that severely damage the surface environment, but its long-term impact on ecosystem services lacks systematic assessment. This study takes the Ordos opencast mining area as an example, and calculates the value of ESV from 1990 to 2020 based on the Google Earth Engine platform.

Two-Dimensional Biodegradable Black Phosphorus Nanosheets Promote Large Full-Thickness Wound Healing through In Situ Regeneration Therapy.

Large full-thickness skin lesions have been one of the most challenging clinical problems in plastic surgery repair and reconstruction. To achieve in situ skin regeneration and perfect clinical outcomes, we must address two significant obstacles: angiogenesis deficiency and inflammatory dysfunction. Recently, black phosphorus has shown great promise in wound healing.

Dynamic modulation of electric and magnetic toroidal dipole resonance and light trapping in Si-GSST hybrid metasurfaces.

The weak coupling of a toroidal dipole (TD) to an electromagnetic field offers great potential for the advanced design of photonic devices. However, simultaneous excitation of electric toroidal dipoles (ETDs) and magnetic toroidal dipoles (MTDs) is currently difficult to achieve. In this work, we propose a hybrid metasurface based on Si and phase transition material (GSST), which is formed by four Si columns surrounding a GSST column and can simultaneously excite two different TD (ETD and MTD) resonances.

Akkermansia muciniphila alleviates high-fat-diet-related metabolic-associated fatty liver disease by modulating gut microbiota and bile acids.

It has been reported that Akkermansia muciniphila improves host metabolism and reduces inflammation; however, its potential effects on bile acid metabolism and metabolic patterns in metabolic-associated fatty liver disease (MAFLD) are unknown. In this study, we have analysed C57BL/6 mice under three feeding conditions: (i) a low-fat diet group (LP), (ii) a high-fat diet group (HP) and (iii) a high-fat diet group supplemented with A. muciniphila (HA).

Bifidobacterium longum R0175 protects mice against APAP-induced liver injury by modulating the Nrf2 pathway.

Acetaminophen (APAP) overdose is the most common driver of drug-induced liver injury (DILI) worldwide, and the gut microbiome plays a crucial role in this process. In this study, we estimated the effect of Bifidobacterium longum R0175 on APAP-induced liver injury in mice and discovered that B. longum R0175 alleviated liver injury by diminishing inflammation, reducing oxidative stress levels, inhibiting hepatocyte death and improving APAP-induced microbiome dysbiosis.

The Relationship between Spatial Characteristics of Urban-Rural Settlements and Carbon Emissions in Guangdong Province.

As containers of human activities, both urban and rural built-up settlements play roles in the increment of regional GHG emissions. This study investigates the relationship between the spatial characteristics of different urban-rural settlements and carbon emissions in Guangdong province, China. After estimating the carbon emissions of 21 cities in Guangdong province from 2005 to 2020, this paper constructs a panel regression model based on the STIPRAT model to identify the impact of different types of urban-rural settlements on carbon emissions with controlling socioeconomic factors.

Desferrioxamine Enhances 5-Aminolaevulinic Acid- Induced Protoporphyrin IX Accumulation and Therapeutic Efficacy for Hypertrophic Scar.

Hypertrophic scar is a common problem after skin burns or trauma which brings physical, psychological, and cosmetic problems to patients. Photodynamic therapy with 5-aminolevulinic acid (5-ALA) is a promising therapy for hypertrophic scar. However, clinical applications of 5-ALA are limited because of the low permeability of 5-ALA in the skin stratum corneum and the rapid binding of protoporphyrin IX (PpIX) with iron ions, which lead to insufficient PpIX production in target tissues.

Intermittent Fasting Alleviates Risk Markers in a Murine Model of Ulcerative Colitis by Modulating the Gut Microbiome and Metabolome.

Clinical trials have demonstrated the health benefits of intermittent fasting (IF). However, the potential mechanism of IF in alleviating dextran sulfate sodium (DSS)-induced colitis is not fully understood. The present study was mainly designed to explore the dynamic changes in the gut microbiota and metabolome after short-term (2 weeks) or long-term (20 weeks) IF and therefore clarify the potential mechanisms by which IF ameliorates DSS-induced colitis in a murine model.

Potential therapeutic drug targets and pathways prediction for premature ovarian insufficiency -Based on network pharmacologic method.

Ethnopharmacological Relevance: The incidence of premature ovarian insufficiency (POI) is gradually increasing, the proportion is rising especially in female infertility patients. The risk of death of POI patients with cardiovascular disease also increases significantly. The cause of POI is complex and unclear, and clinical treatment is still in the exploratory stage, are two major constraints of treating POI.

The negative effect of -mediated post-antibiotic reconstitution of the gut microbiota on the development of colitis-associated colorectal cancer in mice.

The bidirectional relationship between colorectal cancer (CRC) and the gut microbiome has been well-documented. Here, we investigated the impact of -mediated post-antibiotic gut microbial reconstitution on the development of colitis-associated CRC (CAC). The results showed that post-antibiotic replenishment of worsened the tumorigenesis of CAC as indicated by increased number of large (>2 mm in diameter) tumors and both average and total tumor diameters.

5-Aminolevulinic Acid-Hyaluronic Acid Complexes Enhance Skin Retention of 5-Aminolevulinic Acid and Therapeutic Efficacy in the Treatment of Hypertrophic Scar.

Hypertrophic scar is a serious skin disorder, which reduces the patient's quality of life. 5-aminolevulinic acid (5-ALA)-mediated photodynamic therapy has been used to treat patients with hypertrophic scar. However, the poor skin retention of 5-ALA limited the therapeutic effect.

Interleukin-10-Modified Adipose-Derived Mesenchymal Stem Cells Prevent Hypertrophic Scar Formation via Regulating the Biological Characteristics of Fibroblasts and Inflammation.

Hypertrophic scar causes serious functional and cosmetic problem, but no treatment method is known to achieve a satisfactory therapeutic effect. However, mesenchymal stem cells show a possible cure prospect. Here, we investigated the effect of interleukin-10-modified adipose-derived mesenchymal stem cells (IL-10-ADMSC) on the formation of hypertrophic scar.

Ameliorates Infection in Mice by Modulating the Intestinal Microbiome and Metabolites.

is a common cause of nosocomial infection. Antibiotic-induced dysbiosis in the intestinal microbiota is a core cause of infection (CDI). plays an active role in maintaining gastrointestinal balance and might offer the protective effects on CDI as probiotics.

Simultaneously achieving giant piezoelectricity and record coercive field enhancement in relaxor-based ferroelectric crystals.

A large coercive field (E) and ultrahigh piezoelectricity are essential for ferroelectrics used in high-drive electromechanical applications. The discovery of relaxor-PbTiO crystals is a recent breakthrough; they currently afford the highest piezoelectricity, but usually with a low E. Such performance deterioration occurs because high piezoelectricity is interlinked with an easy polarization rotation, subsequently favoring a dipole switch under small fields.

Enhanced Output Performance of Piezoelectric Nanogenerators by Tb-Modified (BaCa)(ZrTi)O and 3D Core/shell Structure Design with PVDF Composite Spinning for Microenergy Harvesting.

Flexible piezoelectric nanogenerators (PENG) have attracted great attention due to their stable electrical output and promising applications in the Internet of Things. To develop a high-performance PENG, a significant relationship among material, structure, and performance precipitates us to design its rational construction. Herein, Tb-modified (BaCa)(ZrTi)O (BCZT) particles have been fabricated into a 3D structure (3D-Tb-BCZT) by the freeze-drying method, and the innovative 3D core/shell structure of 3D-Tb-BCZT-coated 3D-Tb-BCZT/PVDF composite fibers was carried out through the coaxial electrospinning method.