Acetaldehyde dehydrogenase 2 attenuates lipopolysaccharide -induced endothelial barrier damage by inhibiting mitochondrial fission in sepsis-associated encephalopathy.

Sepsis-associated encephalopathy (SAE) is a common neurological complication of sepsis, and acetaldehyde dehydrogenase 2 (ALDH2) has been identified as a protective factor for endothelial cells against oxidative stress. In this study, we aimed to investigate the therapeutic potential of ALDH2 and its impact on mitochondrial dynamics using both mouse and brain microvascular endothelial cells (BMECs) injury models induced by lipopolysaccharide (LPS). Our findings demonstrated that ALDH2 attenuated LPS-induced brain endothelial barrier damage, as evidenced by reduced brain water content and Evans blue dye in mice, decreased transepithelial electrical resistance (TEER), and increased fluorescein isothiocyanate-dextran (FITC-Dextran) leakage in bEnd.

Double-Graph Representation With Relational Enhancement for Emotion-Cause Pair Extraction.

The emotion-cause pair extraction (ECPE) task is to simultaneously extract emotions and causes as pairs (EC-pairs) from documents, which is important for natural language processing. Previous research tackled this task via a two-step approach, which first predicts separately the emotion and cause clauses, and then pairs them up by using a binary classifier. However, such a two-step approach may suffer from the possible propagation of errors, and it neglects the interaction between emotions and causes.

Boosting CO photoreduction over perovskite quantum dots decorated with dispersed ruthenium nanoparticles.

High efficiency CO conversion materials are ideal for solar to carbon fuel conversion. Halide perovskite quantum dots (QDs) are highly desirable as catalysts and have been extensively investigated in the field of CO photoreduction. The major challenge lies in the severe charge recombination and the weak ability to activate CO.

Efficacy of the refined pediatric endoscope equipment management based on the quality control mode.

Objective: To explore the efficacy of refined management based on the quality control (QC) mode in maintaining pediatric endoscope equipment.

Methods: Eighty sets of pediatric endoscopes that were sent to the endoscopy room for cleaning, disinfection, and storage at Hebei Children's Hospital from January 2022 to October 2023 were enrolled. Based on the maintenance method, endoscopes were divided into study group (refined management plus QC mode, n=40) and control group (conventional QC mode, n=40) using a random number table method.

Perioperative care bundle versus conventional perioperative care in pediatric patients undergoing minimally invasive digestive endoscopy.

Objective: To investigate the effect of perioperative care bundle in pediatric patients undergoing minimally invasive digestive endoscopy.

Methods: This was a retrospective study using clinical records of pediatric patients who underwent minimally invasive digestive endoscopy surgery at Hebei Children's Hospital from May 2020 to October 2023. Patients were divided into Care bundle group and Conventional care group based on the treatment received and matched for age, gender, and body mass index in 1:1 ratio.

Synthesis of Mn-doped hollow octahedron ZnInS to enhance photocatalytic hydrogen production performance utilizing metal-organic framework as template.

Designing semiconductor photocatalysts with unique structures can improve the transfer efficiency of solar energy to hydrogen (H). In this study, a dual modification method of element doping and morphological control was used. The Mn-doped hollow octahedron ZnInS (ZHO-Mn) was synthesized by a simple one-pot solvothermal method using the octahedral Mn-based metal-organic framework (Mn-MOF) as a template.

Hollow core-shell heterojunction TAPB-COF@ZnInS as highly efficient photocatalysts for carbon dioxide reduction.

The conversion of carbon dioxide (CO) into carbon-neutral fuels using solar energy is crucial for achieving energy sustainability. However, the high carrier charge recombination and low CO adsorption capacity of the photocatalysts present significant challenges. In this paper, a TAPB-COF@ZnInS-30 (TAPB-COFZ-30) heterojunction photocatalyst was constructed by growth of ZnInS (ZIS) on a hollow covalent organic framework (HCOF) with a hollow core-shell structure for CO to CO conversion.

PD-L1 testing patterns in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) in the U.S.

Background: Pembrolizumab with/without platinum + 5-FU is approved for the first-line (1L) treatment of R/M HNSCC, and its monotherapy use requires PD-L1 Combined Positive Score (CPS) ≥ 1. We aimed to understand PD-L1 testing patterns and associations with patient characteristics and treatment choice in R/M HNSCC.

Methods: Adults with R/M HNSCC initiating 1L systemic therapy were included from a U.

[Optimization of the culture system for chicken small intestinal organoids].

In order to establish a stable in vitro culture platform for chicken small intestine three-dimensional (3D) organoids, in this study, crypt cells were collected from the small intestine of 18-day-old embryos of AA broilers. On the basis of the L-WRN conditioned medium, we optimized the culture conditions of chicken small intestinal organoids by adjusting the proportions of nicotinamide, N-acetylcysteine, LY2157299, CHIR99021, Jagged-1, FGF, and other cytokines to select the medium suitable for the long-term stable growth of the organoids. The optimization results showed that the addition of 1.

Drivers and Obstacles of Consumers' Continuous Participation Intention in Online Pre-Sales: Social Exchange Theory Perspective.

This study focuses on the factors influencing consumers' continuous participation willingness in online pre-sale activities. Based on perceived value and social exchange theory, it analyzes how perceived benefits (including practical benefits, hedonic benefits, and social benefits) and perceived costs (including search costs, waiting costs, and adjustment costs) affect consumer satisfaction and their continuous participation intention in online pre-sales. A total of 527 valid questionnaires were collected, and structural equation modeling was used for data analysis.

Correction: Double triage to identify poorly annotated genes in maize: The missing link in community curation.

[This corrects the article DOI: 10.1371/journal.pone.

Response of heterocyst differentiation of Dolichospermum to different forms of nitrogen deficiency.

In recent years, initiatives aimed at mitigating eutrophication have successfully reduced nitrogen and phosphorus concentrations in numerous lakes across China. Notably, the management of total nitrogen levels has prompted a shift in the dominant genera responsible for harmful algal blooms. Among these, Dolichospermum, a typical diazotrophic cyanobacterium, exhibits the ability to differentiate heterocysts for atmospheric N fixation under nitrogen-limited conditions.

Seeing through "brain fog": neuroimaging assessment and imaging biomarkers for cancer-related cognitive impairments.

Advances in cancer diagnosis and treatment have substantially improved patient outcomes and survival in recent years. However, up to 75% of cancer patients and survivors, including those with non-central nervous system (non-CNS) cancers, suffer from "brain fog" or impairments in cognitive functions such as attention, memory, learning, and decision-making. While we recognize the impact of cancer-related cognitive impairment (CRCI), we have not fully investigated and understood the causes, mechanisms and interplays of various involving factors.

Microneedle patches incorporating zinc-doped mesoporous silica nanoparticles loaded with betamethasone dipropionate for psoriasis treatment.

Treating psoriasis presents a major clinical challenge because of the limitations associated with traditional topical glucocorticoid therapy. This study introduced a drug delivery system utilizing zinc-doped mesoporous silica nanoparticle (Zn-MSN) and microneedle (MN), designed to enhance drug utilization for prolonged anti-inflammatory and anti-itch effects. The MN system facilitated the transdermal delivery of betamethasone dipropionate (BD), allowing its slow release.

Phenotypes of patients with lupus-associated pulmonary hypertension in the Chinese Han population: a cluster analysis.

Objective: Pulmonary hypertension (PH) is a severe complication of systemic lupus erythematosus (SLE). This study investigated the clinical features of patients with SLE-PH in China based on disease manifestations and organ involvement to define precise treatment of SLE and early prevention of complications.

Methods: In total, 205 SLE-PH patients were included in this study.

Photocatalysis coupled electro-Fenton process for treatment of acrylamide wastewater: an optimised study.

Electro-Fenton is a commonly used approach for pollutant removal from different wastewater that requires high energy consumption. Coupling electro-Fenton with solar energy could potentially overcome high power consumption. Thus, this study combined photocatalysis with three-dimensional electro-Fenton to treat acrylamide (AM) wastewater.

Surfactant-tolerance evolution of Bacillus clausii protease for enhancing activity and stability by reshaping the substrate access tunnel.

Alkali proteases are crucial in numerous industries, especially in the laundry industry, but their inactivation by surfactants limits their effectiveness. This study employed substrate access tunnel engineering to improve the performance of WT bcPRO in surfactants. By modifying the key residues in the substrate pocket, the best variant N212S showed higher stability and activity in both AES and LAS.

KC-like chemokine as a biomarker of sepsis in dogs with pyometra.

Background: Sepsis, defined as a dysregulated inflammatory response to infection inducing organ dysfunction, is a common cause of mortality in both humans and animals. Early detection and treatment is essential for survival, but accurate diagnosis is challenging due to the lack of specific biomarkers for sepsis. This study explored the potential of the keratinocyte-derived chemokine (KC)-like protein in dogs as a biomarker of sepsis in dogs with bacterial uterine infection (pyometra).

Assessment of the relationship between the three-dimensional precise location of the mandibular third molar and the volume ratio of the impacted mandibular third molar to the mandibular angle, and the patterns of mandibular angle fracture: A retrospective study.

This study aimed to evaluate the relationship between the precise three-dimensional location of the third molar (M3) and mandibular angle fracture (MAF) patterns and to assess the effect of the volume ratio occupied by M3 in the mandibular angle on fracture patterns. The location of M3 was assessed in 218 patients with MAF using computed tomography reconstruction. The bone volume of the mandibular angle and the bone volume occupied by M3 were measured to calculate the volume ratio of M3 to the mandibular angle (M3/MA).

Real-world treatment patterns, resource utilization and costs in biliary tract cancers in the USA.

To evaluate real-world treatment patterns, survival and healthcare-resource utilization in US patients with advanced biliary tract cancers (BTC) receiving systemic therapy. This study used claims data from the Healthcare Integrated Research Database (HIRD®) linked to clinical data from the Cancer Care Quality Program (January 1, 2015-September 30, 2020). Of 413 patients, 84.

High-quality chromosome scale genome assemblies of two important Sorghum inbred lines, Tx2783 and RTx436.

(L.) Moench is a significant grass crop globally, known for its genetic diversity. High quality genome sequences are needed to capture the diversity.

ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.

Liver sinusoidal endothelial cells (LSECs) have a unique morphological structure known as "fenestra" that plays a crucial role in liver substance exchange and homeostasis maintenance. In this study, we demonstrate that ADAMTS18 protease is primarily secreted by fetal liver endothelial cells. ADAMTS18 deficiency leads to enlarged fenestrae and increased porosity of LSECs, microthrombus formation in liver vessels, and an imbalance of liver oxidative stress.

Post-implantation analysis of genomic variations in the progeny from developing fetus to birth.

The analysis of genomic variations in offspring after implantation has been infrequently studied. In this study, we aim to investigate the extent of de novo mutations in humans from developing fetus to birth. Using high-depth whole-genome sequencing, 443 parent-offspring trios were studied to compare the results of de novo mutations (DNMs) between different groups.

Synonymous variant at the terminal nucleotide in exon 3 of F7 causes abnormal splicing: A case report.

Background: Synonymous variants are non-pathogenic due to non-substitution of amino acids. However, synonymous exonic terminal nucleotide substitutions may affect splicing. Splicing variants are easily analyzed at RNA level for genes expressed in blood cells.