Publications by authors named "Liya Gendler"

Article Synopsis
  • - The study examines how effective MRI is at identifying instability in osteochondritis dissecans (OCD) lesions in the medial femoral condyle of children, with data collected from 59 kids aged around 12.5 years who underwent knee MRIs between 2016 and 2023.
  • - Two radiologists reviewed MRI images to track various factors—like joint effusion and cartilage changes—to classify lesions as stable or unstable. The ultimate determination was based on results from arthroscopy or follow-up evaluations.
  • - Findings showed that while MRI's sensitivity and specificity varied by specific features, certain indicators (like skeletal maturity and cartilage alteration) had strong associations with instability, meaning they could help predict which lesions might require more
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Article Synopsis
  • Osteochondritis dissecans (OCD) affects the osteochondral junction, leading to unstable bone fragments and disrupted cartilage, causing chronic knee pain primarily in children and young adults.
  • The literature mostly discusses OCD in the medial femoral condyle (MFC), but unclear terminology related to patients' skeletal maturity complicates diagnosis and treatment options.
  • This article explores the MFC OCD's pathophysiology, the significance of imaging techniques, and includes a case study connecting imaging findings to the ROCK classification for better management of the condition.*
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The pediatric elbow is a complex joint that undergoes rapid growth and development. The normal anatomy of the elbow varies depending on the age of the patient, which can be challenging for imaging interpretation. This article reviews developmental variants and common pathologies of the pediatric elbow, with a focus on their radiologic features.

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Objective: To systematically investigate the prevalence of knee MRI findings among symptomatic pediatric soccer players with respect to skeletal maturity and to identify predictors of surgery.

Methods: This IRB-approved, HIPAA-compliant retrospective study included soccer players (< 18 years of age) who underwent MRI examinations in the past 5 years (2018-2023). Two radiologists retrospectively and independently reviewed all examinations to categorize skeletal maturity and to identify osseous and soft tissue findings.

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Background: Elbow pain is common among youth baseball players and elbow MRI is increasingly utilized to complement the clinical assessment.

Objective: To characterize, according to skeletal maturity, findings on elbow MRI from symptomatic youth baseball players.

Materials And Methods: This IRB-approved, HIPAA-compliant retrospective study included pediatric (<18 years of age) baseball players with elbow pain who underwent MRI examinations between 2010 and 2021.

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Objective: To investigate MRI findings in children with physeal fractures of the knee with respect to age, location, and articular involvement.

Methods: Children with physeal fractures who underwent knee MRI between 2008 and 2021 were included. Two radiologists retrospectively reviewed all examinations to determine articular involvement, findings of physeal instability (perichondral disruption, periosteal entrapment), and internal derangement (cruciate ligament injury, meniscal tear, chondromalacia).

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Article Synopsis
  • The study examined hand fractures in children under 18, focusing on the characteristics of these fractures related to age and maturity of the skeletal system.
  • Out of 508 cases analyzed, younger children were found to have more phalangeal fractures, while older children had more carpal and metacarpal fractures; displacement and angulation were more common in mature bones.
  • Surgical intervention was rare (11%), with significant predictors for surgery being fracture displacement and articular extension.
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Objective: To compare the diagnostic accuracy and interpretation time for detection of pediatric fractures on hand radiographs with and without localization cues.

Materials And Methods: Consecutive children, who underwent radiographic examinations after injury, over 2 years (2019-2021) and with > 2 weeks of follow-up to confirm the presence or absence of a fracture, were included. Four readers, blinded to history and diagnosis, retrospectively reviewed all images twice, without and with cue, at least 1 week apart and after randomization, to determine the presence or absence of a fracture, and if present, anatomic location and diagnostic confidence were recorded.

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Objective: To assess the feasibility of T2 mapping for evaluating pediatric SIJ cartilage at 3 Tesla (T) magnetic resonance imaging (MRI).

Methods: Healthy control subjects and adolescents with sacroiliitis underwent a 3T MRI dedicated pelvic protocol that included a T2 mapping sequence consisting of multislice, multiecho acquisition. Healthy control subjects were prospectively recruited from our primary care practices as part of a larger imaging study, whereas adolescents with sacroiliitis were recruited specifically for this study.

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Background: Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory bone disorder affecting children and adolescents. Previously classified as a rare disease, recent studies suggest a higher incidence of the disease. CNO may develop into the clinical presentation of chronic recurrent osteomyelitis (CRMO) with high relapse rate and multifocality.

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Background: Determination and longitudinal monitoring of progressive skeletal maturity are essential in the management of children with scoliosis. Although different methods for determining skeletal maturity exists, the most widely practiced method relies on the ossification pattern of the bones of the hand and wrist, which is traditionally acquired using conventional techniques and after the acquisition of the spine using the low-dose slot-scanning technique. Whereas the existing published literature has published promising results on the use of the slot-scanning technique to acquire these hand and wrist radiographs, image quality and radiation dose have not been systematically compared between these techniques.

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Tramadol is a centrally acting analgesic that acts via μ-opioid agonism and by blocking the neuronal uptake of norepinephrine and serotonin. Clonidine potentiates the antinociceptive effects of tramadol; however the receptors involved in this potentiation have not been studied. Endothelin ET(A) receptor antagonists potentiate antinociceptive effects of morphine and oxycodone; however the effects of endothelin ET(A) receptor antagonists on tramadol antinociception have not been evaluated.

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