Publications by authors named "Lixuan Lu"
Article Synopsis
- * Disruption of protein folding in the endoplasmic reticulum (ER) leads to stress and activation of crucial pathways like the Unfolded Protein Response (UPR) and Endoplasmic Reticulum-Associated Degradation (ERAD).
- * Failure of UPR and ERAD can result in cellular damage, neuroinflammation, and involve complex interactions among the ER, mitochondria, lysosomes, and Golgi apparatus in the neurodegenerative process.
Article Synopsis
- This study focuses on the construction of a neourethra for female-to-male transsexual patients undergoing phalloplasty, specifically using vaginal mucosal grafts.
- A review of 22 FTM patients who underwent this procedure showed positive outcomes, with most patients able to void while standing and a relatively low incidence of complications like urethral fistulas and strictures.
- The research indicates that vaginal mucosa is a suitable and effective material for reconstructing the urethra due to its histological similarities to urethral epithelium and its successful integration in the body.
The purposes f this study were to (i) explore the possibility of splitting the selected forearm muscles into separate compartments in human subjects; (ii) quantify the architectural properties of each neuromuscular compartment; and (iii) discuss the implication of these properties in split tendon transfer procedures. Twenty upper limbs from 10 fresh human cadavers were used in this study. Ten limbs of five cadavers were used for intramuscular nerve study by modified Sihler's staining technique, which confirmed the neuromuscular compartments.
View Article and Find Full Text PDFBackground: Cross-leg flaps are a good choice for reconstructing traumatized lower extremities, especially when free flaps cannot be used. In this article, we present our experience in the treatment of traumatic lower extremity wounds by using cross-leg flaps.
Study Design: A total of 56 patients suffering traumatic lower extremities were treated with cross-leg flaps.
[Research progress of soft tissue defect repair around the knee].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
September 2012
Objective: To review the research progress of the skin flap, fascial flap, muscle flap, and myocutaneous flap for repairing soft tissue defects around the knee so as to provide information for clinical application.
Methods: Domestic and abroad literature concerning the methods of soft tissue repair around the knee in recent years was reviewed extensively and analyzed.
Results: Fascial flaps meet the requirements of thin, pliable, and tough skin in the soft tissue repair around the knee.
Rapid increases in incidence and mortality of human malignant melanoma are observed worldwide; thus, the development of new effective chemicals to control melanoma is urgent. In this study, the cytotoxic effect of oxymatrine, a natural quinolizidine alkaloid, against three human melanoma cell lines (A375, Sk-Mel-28, MM96L) and the underlying mechanisms were investigated. Oxymatrine killed all three human melanoma cell lines in a dose-dependent manner.
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