Fe@FeGe nanoparticles for MR imaging-guided NIR-driven photodynamic therapy in vivo.

Photodynamic therapy (PDT) has attracted much attention as a useful technique for disease therapy, considering its minimum invasiveness, high spatial-temporal control, and specific lesion destruction. However, the limited generation of singlet oxygen (1O2) in PDT has restricted the practical biomedical applications of photosensitizers. To overcome this issue, we first developed iron nanoparticles as an Fe nanotemplate to synthesize iron germanium nanoalloy coated iron nanoparticles (Fe@Fe3Ge2 NPs), which possess strong near-infrared (NIR) absorption, as a highly stable photosensitizer and to generate 1O2 effectively under irradiation by an 808 nm laser for NIR-PDT via the mitochondrial apoptotic pathway.

Coordination polymer hybridized Au nanocages: a nanoplatform for dual-modality imaging guided near-infrared driven photothermal therapy in vivo.

Coordination polymer hybridized Au nanocages (AuNC@CPs) were prepared via a dialysis process by combining Au nanocages with a coordination polymer, which was derived from (pq)Ir(Hdcbpy) and Dy(OOCCH). After hybridization, the localized surface plasmon resonance (LSPR) peak of the AuNC@CPs exhibited an evident red shift in comparison with that of the Au nanocages, which was due to a variation in the dielectric constant caused by the coordination polymer. Notably, inspired by their excellent photothermal, photoacoustic, and magnetic properties in solution, AuNC@CPs were used for near-infrared (NIR)-driven photothermal therapy (PTT) guided by photoacoustic (PA) and magnetic resonance (MR) imaging in vivo.