Molecular epidemiology of Escherichia coli in bloodstream infections from a general hospital in Ningxia, China, 2022-2023.

Objective: To analyse the antibiotic resistance, resistance genes and clonal relationship of Escherichia coli in bloodstream infections in Ningxia from 2022 to 2023.

Methods: We retrospectively analyzed the antibiotic susceptibilities of 257 isolates. PCR was used to detect bla, bla, bla, qnrS, qnrA, qnrB, oqxA, qepA, gyrA, gyrB, parC, and parE, and the clonal relationship through multilocus sequence typing (MLST).

710 kW stable average power in a 45,000 finesse two-mirror optical cavity.

Very high-average optical enhancement cavities (OECs) are being used both in fundamental and applied research. The most demanding applications require stable megawatt level average power of infrared picosecond pulses with repetition rates of several tens of MHz. Toward reaching this goal, we report on the achievement of 710 kW of stable average power in a two-mirror hemispherical optical enhancement cavity.

Instantaneous and Retarded Interactions in Coherent Radiation.

In coherent radiation of an ensemble of electrons, the radiation field from electrons resonantly drives the other electrons inside to produce stimulated emission. The radiation reaction force on the electrons accounting for this stimulated radiation loss is classically described by the Liénard-Wiechert potential. Despite its being the foundation of beam physics for decades, we show that using the "acceleration field" in Liénard-Wiechert potential to describe radiative interactions leads to divergences due to its implicit dependence on instantaneous interactions.

Safety and immunogenicity of multivalent SARS-CoV-2 protein vaccines: a randomized phase 3 trial.

Background: COVID-19 vaccines that offer broad-spectrum protection are needed. We aimed to evaluate the safety and immunogenicity of multivalent vaccines, SCTV01E and SCTV01C, and compare them with an inactivated vaccine.

Methods: In the phase 3 trial (ClinicalTrials.

Taxi drivers' traffic violations detection using random forest algorithm: A case study in China.

Objective: To effectively explore the impacts of several key factors on taxi drivers' traffic violations and provide traffic management departments with scientific decisions to reduce traffic fatalities and injuries.

Methods: 43,458 electronic enforcement data about taxi drivers' traffic violations in Nanchang City, Jiangxi Province, China, from July 1, 2020, to June 30, 2021, were utilized to explore the characteristics of traffic violations. A random forest algorithm was used to predict the severity of taxi drivers' traffic violations and 11 factors affecting traffic violations, including time, road conditions, environment, and taxi companies were analyzed using the Shapley Additionality Explanation (SHAP) framework.

Safety and immunogenicity of a bivalent SARS-CoV-2 protein booster vaccine, SCTV01C, in adults previously vaccinated with mRNA vaccine: a randomized, double-blind, placebo-controlled phase 1/2 clinical trial.

Background: Booster vaccination is an efficient way to address the waning protection of vaccines and immune escape of SARS-CoV-2 variants. We aimed to assess the safety and immunogenicity of SCTV01C, a novel bivalent protein vaccine as a booster for people who previously received two doses of mRNA vaccine.

Methods: In this randomized, phase 1/2 trial, adults fully vaccinated with mRNA vaccines 3-24 month earlier were enrolled.

Visualization and Analysis of Global Vision Zero Studies and Policy Orientation in China.

As a policy that is widely used worldwide, Vision Zero is a long-term strategic goal for road safety in China. The aim of this paper is to examine the literature in the field of Vision Zero retrieved by the Web of Science (WOS) Core Collection database from 1997 to 2021 based on mapping knowledge domain (MKD) and bibliometric methods. In this paper, we analyzed the overall development level of Vision Zero at different stages using the statistical analysis of the distribution of literature years.

Forecasting and Planning Method for Taxi Travel Combining Carbon Emission and Revenue Factors-A Case Study in China.

The efficiency and emission levels of taxi operations are influenced by taxi drivers' empirical judgments of hotspot travel areas. In this study, we exploited vehicle specific power (VSP) approaches and taxi trajectory data in a 1000 × 1000 m grid to calculate emission and revenue efficiency-related indicators and explored their spatial and temporal characteristics. Then, the entropy weight TOPSIS method was employed to identify the grids with the top comprehensive ranking of the indicators in the period to replace the driver experience.

A Take-Over Performance Evaluation Model for Automated Vehicles from Automated to Manual Driving.

The evaluation of take-over performance and take-over safety performance is critical to improving the take-over performance of conditionally automated driving, and few studies have attempted to evaluate take-over safety performance. This study applied a binary logistic model to construct a take-over safety performance evaluation model. A take-over driving simulator was established, and a take-over simulation experiment was carried out.

Visualization and Analysis of Mapping Knowledge Domain of Heterogeneous Traffic Flow.

Mapping knowledge domain (MKD) is an important application in bibliometrics, which is a method of visually presenting and explaining newly developed interdisciplinary scientific fields using data mining, information analysis, scientific measurement, and graphic rendering. This study combines applied mathematics, visual analysis technology, information science, and scientometrics to systematically analyze the development status, research distribution, and future trend of the heterogeneous traffic flow by using the MKD software tools VOSviewer and CiteSpace. Based on the MKD and Bibliometrics approaches, 4709 articles have been studied, which were published by Science Citation Index Expanded (SCIE) and Social Sciences Citation Index (SSCI) from 2004 to 2021 in the field of heterogeneous traffic flows.

A Double-Layered Belief Rule Base Model for Driving Anger Detection Using Human, Vehicle, and Environment Characteristics: A Naturalistic Experimental Study.

"Road rage," namely, driving anger, has been becoming increasingly common in auto era. As "road rage" has serious negative impact on road safety, it has attracted great concern to relevant scholar, practitioner, and governor. This study aims to propose a model to effectively and efficiently detect driving anger states with different intensities for taking targeted intervening measures in intelligent connected vehicles.

A Mixed Decision Strategy for Freight and Passenger Transportation in Metro Systems.

This paper proposes a mixed decision strategy for freight and passenger transportation in metro systems during off-peak hours (MTS-OPH). The definition of the mixed decision strategy is proposed, and fixed and flexible loading modes are considered for different passenger flow volumes. A mathematical model of the MTS-OPH is proposed and solved using an improved variable neighborhood search algorithm.

Safety, Tolerability, Pharmacokinetics, and Immunogenicity of a Monoclonal Antibody (SCTA01) Targeting SARS-CoV-2 in Healthy Adults: a Randomized, Double-Blind, Placebo-Controlled, Phase I Study.

SCTA01 is a novel monoclonal antibody with promising prophylactic and therapeutic potential for COVID-19. This study aimed to evaluate the safety, tolerability, pharmacokinetics (PK) and immunogenicity of SCTA01 in healthy adults. This was a randomized, double-blind, placebo-controlled, dose escalation phase I clinical trial.

Experimental demonstration of the mechanism of steady-state microbunching.

The use of particle accelerators as photon sources has enabled advances in science and technology. Currently the workhorses of such sources are storage-ring-based synchrotron radiation facilities and linear-accelerator-based free-electron lasers. Synchrotron radiation facilities deliver photons with high repetition rates but relatively low power, owing to their temporally incoherent nature.

Prior-damage dynamics in a high-finesse optical enhancement cavity.

An observation of prior-damage behavior inside a high-finesse optical resonator is reported. Intra-cavity average power drops appeared with magnitude and time scale depending on the power level. Increasing further the incident laser beam power led to irreversible damage of the cavity coupling mirror surface.

Self-assembling peptide-etoposide nanofibers for overcoming multidrug resistance.

We developed a new strategy to overcome the MDR of etoposide using self-assembling nanofibers. Compared with the original etoposide, the inhibitory activity of Nap-GFFpYK-etoposide1/2 against murine Lewis lung cancer or breast cancer cells was increased 10 times, and 20 times on these cells with artificially overexpressed MDR1. Our method to synthesize and separate etoposide isomers provides a new strategy for the modification of this drug.

Long Noncoding RNA Rps4l Mediates the Proliferation of Hypoxic Pulmonary Artery Smooth Muscle Cells.

Pulmonary hypertension (PH) is a rare and fatal disorder involving the vascular remodeling of pulmonary arteries mediated by the enhanced proliferation of pulmonary artery smooth muscle cells (PASMCs). Long noncoding RNAs are a subclass of regulatory molecules with diverse cellular functions, but their role in PH remains largely unexplored. We aimed to identify and determine the functions of long noncoding RNAs involved in hypoxia-induced PH and PASMC proliferation.

Sodium Selenite Improves The Therapeutic Effect Of BMSCs Via Promoting The Proliferation And Differentiation, Thereby Promoting The Hematopoietic Factors.

Purpose: Sodium selenite (NaSeO) has been known to restore the antioxidant capacity of bone marrow mesenchymal stem cells (BMSCs), reduce the production of reactive oxygen species (ROS) in the cells, and promote cell proliferation and inhibit cell apoptosis. However, it is still not clear whether selenium can mediate the differentiation and inhibit the induced hemagglutination of BMSCs. In this study, we attempted to explore the effect of NaSeO on these aspects of BMSCs.

Linearly polarized laser beam with generalized boundary condition and non-paraxial corrections.

Linearly polarized Gaussian beams, under the slowly varying envelope approximation, tightly focused by a perfect parabola modeled with the integral formalism of Ignatovsky are found to be well approximated with a generalized Lax series expansion beyond the paraxial approximation. This allows obtaining simple analytic formulas of the electromagnetic field in both the direct and momentum spaces. It significantly reduces computing time, especially when dealing with the problem of simulating direct laser acceleration.

A novel feature extraction model for traffic injury severity and its application to Fatality Analysis Reporting System data analysis.

The prevention of severe injuries during crashes has become one of the leading issues in traffic management and transportation safety. Identifying the impact factors that affect traffic injury severity is critical for reducing the occurrence of severe injuries. In this study, the Fatality Analysis Reporting System data are selected as the dataset for the analysis.