Publications by authors named "Lixin Shi"
Previous studies suggested that fecal short-chain fatty acids (SCFAs) and branched short-chain fatty acids (BCFAs) are associated with glucose regulation. However, the potential relationship between circulating SCFAs and BCFAs with incident diabetes risk in both men and women remains unidentified in prospective cohort studies. In this study, we examined a panel of nine serum SCFAs and BCFAs in 3414 subjects with incident diabetes, and matched normoglycemic controls from the China Cardiometabolic Disease and Cancer Cohort study.
View Article and Find Full Text PDFAims: To determine the impact of body roundness index (BRI) on the 10-year risk of cardiovascular disease (CVD) and all-cause mortality in Chinese adults.
Materials And Methods: We utilized data from a nationwide prospective cohort of 165 785 Chinese adults (aged ≥40 years, free of CVD and cancer at baseline), which was extracted from the China Cardiometabolic Disease and Cancer Cohort (4C). Cox regression and restricted cubic splines quantified BRI-outcome associations and identified optimal BRI cutoffs.
Objective: Oral squamous cell carcinoma (OSCC) is a common type of head and neck cancer with high metastasis rate and poor prognosis. This study aimed to explore the role of collagen type XI alpha 1 (COL11A1) and its detailed mechanisms in OSCC progression.
Methods: Quantitative reverse transcription polymerase chain reaction (RT-qPCR) analysis was used to measure the level of COL11A1, fused in sarcoma/translocated in liposarcoma (FUS) and zinc finger E-box binding homeobox 1 (ZEB1).
Understanding sex disparities in modifiable risk factors across the lifespan is essential for crafting individualized intervention strategies. We aim to investigate age-related sex disparity in cardiometabolic phenotypes in a large nationwide Chinese cohort. A total of 254,670 adults aged 40 years or older were selected from a population-based cohort in China.
View Article and Find Full Text PDFObjective: To assess the effect of dapagliflozin plus calorie restriction on remission of type 2 diabetes.
Design: Multicentre, double blind, randomised, placebo controlled trial.
Setting: 16 centres in mainland China from 12 June 2020 to 31 January 2023.
This study aimed to comprehensively examine the association of gallstones, cholecystectomy, and cancer risk. Multivariable logistic regressions were performed to estimate the observational associations of gallstones and cholecystectomy with cancer risk, using data from a nationwide cohort involving 239 799 participants. General and gender-specific two-sample Mendelian randomization (MR) analysis was further conducted to assess the causalities of the observed associations.
View Article and Find Full Text PDFBackground: Diabetes, a chronic disease necessitating long-term treatment and self-management, presents significant challenges for patients who spend most of their treatment time outside of hospitals. The potential of digital therapeutics for diabetes has garnered recognition from different organizations. Although some prior studies have demonstrated successful reductions in patients' blood glucose levels and body weight through digital diabetes programs, many studies were limited by including patients with prediabetes, including patients treated with mostly premixed insulin, or evaluating user engagement outcomes rather than clinical outcomes.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the link between type 2 diabetes and cardiovascular disease (CVD) within a population-based cohort, focusing on blood pressure, HbA1c levels, and lipid profiles.
- Data was analyzed from 7,197 adults, revealing that those with diabetes had a significantly higher risk of CVD events, especially when presenting with high blood pressure and lipid levels.
- The findings suggest that effective management of cardiovascular risk factors could help reduce the increased CVD risk associated with diabetes.
Prevalence and Risk Factors of Chronic Kidney Disease in Patients With Type 2 Diabetes in China: Cross-Sectional Study.
JMIR Public Health Surveill
August 2024
Article Synopsis
- Chronic kidney disease (CKD) is a serious complication of diabetes that can lead to end-stage kidney disease; this study focused on its prevalence and risk factors among Chinese type 2 diabetes patients.
- The ongoing IMPROVE study analyzed data from 9,672 patients with type 2 diabetes, involving various assessments like blood tests and questionnaires to gather comprehensive health information.
- Findings showed a CKD prevalence of 31% among participants, with significantly low screening (27%) and high awareness rates (54.8%); factors impacting CKD risk included screening practices, awareness, smoking, age, and duration of diabetes.
Article Synopsis
- The study examines how education impacts the prevalence of cardiovascular-kidney-metabolic (CKM) syndrome in middle-aged and older Chinese individuals, highlighting significant gender differences.
- Using data from a large population-based study, researchers found that low educational attainment increased the likelihood of moderate and high CKM syndrome, particularly among women.
- Results suggest that poor health behaviors, influenced by education, significantly affect CKM syndrome risks, emphasizing the need for interventions that address social determinants of health.
Article Synopsis
- Scientists studied how things like education, lifestyle, and health can affect death rates in older adults in China.
- They found that 17 factors were linked to a lot of the deaths, showing that low education and high blood pressure were some of the biggest reasons people died from different causes.
- The study suggested that understanding these risks can help create better health programs to keep people healthier and reduce deaths in China.
Serum Medium-Chain Fatty Acids and the Risk of Incident Diabetes: Findings From the 4C Study.
J Clin Endocrinol Metab
January 2025
Article Synopsis
- Emerging studies suggest a link between medium-chain fatty acids (MCFAs) in the diet and glucose regulation, but the specific role of serum MCFAs in diabetes risk, especially concerning genetic factors, needs further exploration.
- A nested case-control study analyzed baseline serum MCFAs from 1,707 individuals with type 2 diabetes (T2DM) and matched healthy controls, examining both MCFAs' overall effects and their interactions with genetic risk scores based on T2DM-linked genetic variants.
- Results indicated that higher levels of octanoic and nonanoic acids were associated with lower diabetes risk, particularly in physically inactive individuals and those with high genetic risk, suggesting a complex interplay between these fatty acids and genetic predisposition in diabetes
Artificial light can affect eyeball development and increase myopia rate. Matrix metalloproteinase 2 (MMP-2) degrades the extracellular matrix, and induces its remodeling, while tissue inhibitor of matrix MMP-2 (TIMP-2) inhibits active MMP-2. The present study aimed to look into how refractive development and the expression of MMP-2 and TIMP-2 in the guinea pigs' remodeled sclerae are affected by artificial light with varying spectral compositions.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the association between the triglyceride glucose (TyG) index and breast cancer risk in Chinese women, using data from a large sample of 142,184 participants aged 40 or older.
- - Results indicate that women in the highest quartile of the TyG index have a 61% increased risk of prevalent breast cancer compared to those in the lowest quartile, with certain demographics showing even stronger associations.
- - The findings suggest that the TyG index may be a useful marker for assessing breast cancer risk, especially among women without insulin resistance or metabolic issues.
Article Synopsis
- Long-chain free fatty acids (FFAs) have a potential link to diabetes risk, particularly in populations that have normal blood sugar levels, which requires further exploration.
- The study used a comprehensive approach to measure 53 types of FFAs in a cohort of 1,707 individuals who developed diabetes and 1,707 matched controls, employing various statistical models to assess risk associations.
- Findings indicated that odd-chain and specific even-chain FFAs were inversely associated with diabetes risk, with odds ratios suggesting that higher levels of certain saturated, monounsaturated, and polyunsaturated fatty acids could lower the risk of developing diabetes.
Aims: Accumulating evidences indicate that abnormalities in tubular lipid metabolism play a crucial role in the development of diabetic kidney disease (DKD). We aim to identify novel lipid metabolism-related genes associated with tubular injury in DKD by utilizing bioinformatics approaches.
Methods: Differentially expressed genes (DEGs) between control and DKD tubular tissue samples were screened from the Gene Expression Omnibus (GEO) database, and then were intersected with lipid metabolism-related genes.
Aims: To assess the excess risk of cardiovascular disease (CVD) associated with different criteria for metabolic health, and the interplay of body size, insulin sensitivity and metabolic health with CVD risk.
Materials And Methods: We conducted a prospective study involving 115 638 participants from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. Metabolic health was defined using three different definitions: (1) insulin sensitivity defined by homeostatic model assessment of insulin resistance index; (2) absence of metabolic syndrome according to the National Cholesterol Education Program Adult Treatment Panel III criteria; and (3) simultaneous absence of metabolic abnormalities (diabetes, hypertension, dyslipidaemia).
Background/aims: : Low educational attainment is a well-established risk factor for nonalcoholic fatty liver disease (NAFLD) in developed areas. However, the association between educational attainment and the risk of NAFLD is less clear in China.
Methods: : A cross-sectional study including over 200,000 Chinese adults across mainland China was conducted.
Objectives: This study endeavors to augment comprehension of the association between breastfeeding and maternal weight within Asian populations.
Methods: Data were obtained from the comprehensive 2011 research titled "Risk Evaluation of Cancers in Chinese Diabetic Individuals (REACTION): a longitudinal analysis," focusing specifically on postmenopausal women residing in the metropolitan precincts of Guiyang. It presents a cross-sectional study involving 5,987 parous postmenopausal women, aged 60.
Almost all orchids rely on mycorrhizal fungus to support their seed germination. To date, the effect of active components in mycorrhizal fungus on orchid seed germination largely remains unknown. In this study, we aimed to investigate the impact of active components found in mycorrhizal fungus on orchid seed germination.
View Article and Find Full Text PDFArticle Synopsis
- Research shows a U-shaped relationship between sleep duration and chronic kidney disease (CKD), indicating that both insufficient and excessive sleep can negatively affect kidney health.
- A study involving over 100,000 participants found that replacing 1 hour of excessive sleep with physical activities like walking or moderate exercise significantly reduces CKD prevalence, with leisure activities being more effective than occupational ones.
- Long sleepers, especially those with diabetes, benefit more from reallocating time to physical activity, highlighting the need to optimize sleep patterns and overall behavioral activities for better kidney health.
Background: The association between weight change during early adulthood and cardiometabolic diseases remains uncertain in Chinese population. Whether the association varies with comprehensive cardiovascular health (CVH) in midlife assessed by "Life's Essential 8" has not been characterized. We aim to examine the associations of early adulthood weight change and midlife "Life's Essential 8" CVH status with cardiometabolic outcomes in a Chinese cohort.
View Article and Find Full Text PDFPurpose: This study aimed to investigate the incidence of metabolic syndrome (MS) in people over 40 years of age with normal blood glucose levels in Guiyang's urban areas and determine the effective glycemic cutoff value for predicting MS.
Methods: The analysis was based on anthropometric and biochemical indicators of residents aged 40 years or older in urban areas of Guiyang City who participated in the "Epidemiological Study of Tumor Risk in Chinese Patients with Type 2 Diabetes" in 2011. This study included 3509 patients (2567 females and 942 males) with normal fasting plasma glucose (FPG) and no MS.