Publications by authors named "Lixin Kuai"
Behavioral studies of the abuse potential and anesthetic and sedative effects of etomidate in male rodents.
Psychopharmacology (Berl)
November 2024
Article Synopsis
- Etomidate is a short-acting anesthetic gaining attention due to its potential for abuse, especially when mixed in e-cigarettes, yet it has not been researched for its abuse potential until now.
- This study used tests on male mice and rats to evaluate etomidate's rewarding and reinforcing effects, finding that specific doses caused conditioned place preference and led to the self-administration of the drug.
- Results indicate that etomidate has significant abuse potential in rodents, demonstrating rewarding effects, which raises concerns about its possible abuse in humans.
Assessment of pharmacological effects and abuse potential of 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201 in mice.
Psychopharmacology (Berl)
October 2024
Rationale: The newly emerging synthetic cannabinoids (SCs) 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201 have been observed to produce effects by activating cannabinoid type 1 (CB1) receptors. Nevertheless, the pharmacological effects and potential for abuse of these three substances remain to be studied. These substances have yet to be regulated in many countries.
View Article and Find Full Text PDFIsobutyryl-carfentanyl has strong acute toxicity and analgesic effects with high addiction potential.
Psychopharmacology (Berl)
August 2024
Rationale: Isobutyryl-carfentanyl is the most recently discovered fentanyl analogue with a chemical structure that is similar to that of carfentanyl. Its analogue, carfentanyl, is regarded as one of the most lethal drugs in the world, with a potency of 10,000 times that of morphine. Therefore, isobutyryl-carfentanyl may possess a comparably high potency and its harmful effects cannot be ignored.
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