Publications by authors named "Lixiang Wu"

Triclosan (TCS), a typical endocrine disruptor, is widely used as an antibacterial agent in consumer goods. However, there are few studies on the effects of long-term low-dose TCS exposure on ovarian function in F1 female mice. In this paper, F1 female mice were exposed to TCS (0-3000 μg/kg/day) from intrauterine to postnatal day (PND) 91 to investigate its effects on the ovary.

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Objective: To investigate the influencing factors of inpatients giving red packets to doctors and explore the necessity of doctor-patient red packet agreements.

Methods: A questionnaire survey was conducted among inpatients and their families who were hospitalized in several hospitals in Chengdu from January to June 2023. The survey asked about the patients' (or their families') attitudes and opinions on whether it was necessary to give red packets to doctors during hospitalization.

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Intraventricular hemorrhage in preterm neonates has become a major global health problem and is associated with a high risk of post-hemorrhagic hydrocephalus (PHH). Identifying diagnostic markers and therapeutic targets is a focal challenge in the PHH prevention and control. Here, this study applies multi-omics analyses to characterize the biochemical, proteomic, and metabolomic profiles of the cerebrospinal fluid (CSF) in clinical human cohorts to investigate disease development and recovery processes occurring due to PHH.

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  • The research examines how the diversity of microbial communities on flue-cured tobacco relates to its flavor and quality, utilizing high-throughput sequencing to analyze samples from Yunnan.
  • A specific bacterial strain, W6-2, was identified for its pectin-degrading ability, and its fermentation-derived enzyme preparation was applied to tobacco to assess quality improvements.
  • The study found that this enzyme treatment enhanced the aroma and sweetness of the tobacco, changed the levels of various compounds, and demonstrated a significant link between surface microorganisms and the volatile components affecting tobacco quality.
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  • An ultrasensitive electrochemical immunosensor for detecting pro-gastrin-releasing peptide (ProGRP) was developed using PtCu nanodendrites on Au/polyaniline nanospheres.
  • * The sensor benefits from the synergistic effects of its components, providing excellent electro-catalytic activity and a large surface area for antibody immobilization.
  • * It demonstrated impressive sensitivity with a detection range from 100 fg/mL to 10 ng/mL and a low limit of detection of 77.62 fg/mL.
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  • This study investigated how the immune system responds to SARS-CoV-2 infection by focusing on the humoral (antibody) response.
  • Researchers used a method called chemiluminescent immunoassay (CLIA) to measure neutralizing antibodies and IgG in patients.
  • Findings revealed that neutralizing antibodies peaked between days 57-96 after symptoms appeared and showed varying patterns among patients, indicating their importance for tracking COVID-19 progression and antibody protection.
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  • Triclosan (TCS) is a common antibacterial chemical that may influence the timing of female puberty development, with studies suggesting low-dose exposure could have developmental effects.
  • In an experiment, female mice were exposed to varying doses of TCS before mating and during early development, leading to an earlier onset of puberty by about 3 days in their offspring.
  • The study found that TCS affects hormonal regulation by increasing estradiol secretion and altering gene expression related to ovarian function, suggesting specific cellular mechanisms like L-type calcium channels and Pik3cd are involved in these changes.
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SREBPs, such as SREBP1 and SREBP2, were the key transcriptional factors regulating lipid metabolism. The processing of SREBPs involved many genes, such as scap, s1p, s2p, cideb. Here, we deciphered the full-length cDNA sequences of scap, srebp1, srebp2, s1p, s2p, cideb and cidec from yellow catfish Pelteobagrus fulvidraco.

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In recent years, the phenomenon of abnormal pubertal timing in children has become increasingly common worldwide. Persistent organic pollutants (POPs) may be one of the risk factors contributing to this phenomenon, but the relationship between them is unclear based on current evidence. The purpose of this study was to determine the association of POPs exposure with pubertal timing in girls and boys by conducting a systematic review and meta-analysis.

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Objectives: Paired box gene 6 () plays a major role in the regulation of embryonic development. Abnormal expression of PAX6 is associated with the development of various tumors. PAX6 can play a role in promoting or suppressing cancer in different tumors.

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Metabolic stress induces lipophagy, a crucial process in lipid catabolism, which is under the regulation of autophagy involving transcription factor EB (TFEB). However, the precise mechanisms underlying TFEB's control remain enigmatic. In this study, we focused on yellow catfish (Pelteobagrus fulvidraco) as the model to investigate lipophagy activation under high glucose-induced lipid deposition.

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Zinc (Zn) is a multipurpose trace element indispensable for vertebrates and possesses essential regulatory roles in lipid metabolism, but the fundamental mechanism remains largely unknown. In the current study, we found that a high-Zn diet significantly increased hepatic Zn content and influenced the expression of Zn transport-relevant genes. Dietary Zn addition facilitated lipolysis, inhibited lipogenesis, and controlled β-catenin signal; Zn also promoted T-cell factor 7-like 2 (TCF7L2) to interact with β-catenin and regulating its transcriptional activity, thereby inducing lipolysis and inhibiting lipogenesis; Zn-induced lipid degradation was mediated by histone deacetylase 3 (HDAC3) which was responsible for β-catenin deacetylation and the regulation of β-catenin signal under the Zn treatment.

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We aimed to explore the correlations between and possible mechanisms of common environmental endocrine disruptors, phthalates, and ovarian dysfunction in endometriosis. Subjects were included in the case group ( = 107) who were diagnosed with endometriosis by postoperative pathology in Fujian Maternal and Child Hospital from February 2018 to February 2021, and the women who were excluded from endometriosis by surgery were as the control group ( = 70). The demographic information of the subjects were evaluated by questionnaire, and the clinical characteristics were evaluated by medical records and 3-year follow-up results.

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  • Traditional Chinese medicine (TCM) is known for its effectiveness in disease prevention and treatment with fewer side effects, making it popular globally.
  • Endocrine disrupting chemicals (EDCs), which are prevalent in daily life, can negatively impact human hormones, potentially leading to fertility issues, obesity, and energy imbalances.
  • The paper reviews existing research on EDC contamination in TCM, examining sources of pollution during its production and processing, along with the associated health risks of EDC exposure through TCM consumption.
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Background: As a new type of regulatory cell death, ferroptosis has been proven to be involved in cancer pathogenesis and therapeutic response. However, the detailed roles of ferroptosis or ferroptosis-associated genes in glioma remain to be clarified.

Methods: Here, we performed the TMT/iTRAQ-Based Quantitative Proteomic Approach to identify the differentially expressed proteins between glioma specimens and adjacent tissues.

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Glycophagy is the autophagy degradation of glycogen. However, the regulatory mechanisms for glycophagy and glucose metabolism remain unexplored. Herein, we demonstrated that high-carbohydrate diet (HCD) and high glucose (HG) incubation induced glycogen accumulation, protein kinase B (AKT)1 expression and AKT1-dependent phosphorylation of forkhead transcription factor O1 (FOXO1) at Ser238 in the liver tissues and hepatocytes.

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Differentiated thyroid cancer is the most frequently diagnosed endocrine tumor. While differentiated thyroid cancers often respond to initial treatment, little is known about the differences in circulating immune cells amongst patients who respond differently. A prospective study of 39 patients with differentiated thyroid cancer was conducted.

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  • - The study presents a non-acidic method for recovering copper and precious metals from mobile phone circuit boards, focusing on gold and silver enrichment through a process involving cuprous chloride synthesis.
  • - The efficiency of gold and silver recovery is influenced by the [Cu]/[Cu] ratio, allowing for higher recovery rates in the residue compared to raw circuit board materials.
  • - The new process boasts a high leaching efficiency (93.8% silver and 99% gold) while avoiding hazardous chemicals like HNO3 and aqua regia, making it an environmentally friendly option for e-waste metal recovery.
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  • The study investigates how total thyroidectomy and radioactive iodine therapy (RAIT) affect immune function in patients with differentiated thyroid carcinoma (DTC).
  • Results showed that patients had significantly lower circulating regulatory T cell levels post-surgery compared to healthy controls; however, some immune cell counts recovered after 90 days.
  • The levels of Th17 cells before RAIT were linked to thyroglobulin levels following treatment, suggesting their potential as a predictor for poor prognosis in DTC patients.
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  • The study investigates the effectiveness of tivantinib compared to a placebo in treating MET-high hepatocellular carcinoma.
  • Researchers conducted a systematic review of multiple databases up to March 2022, focusing on randomized controlled trials (RCTs) involving tivantinib.
  • The results indicate that tivantinib does not significantly improve overall survival or other key outcomes compared to placebo, but it does increase the risk of severe neutropenia.
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  • - The study investigates the connection between gut microbiota, inflammation, and hypertensive intracerebral hemorrhage (HICH), which is becoming more common and is linked to high mortality and morbidity rates.
  • - Researchers found that patients with HICH showed increased levels of inflammatory markers in blood and brain, decreased diversity in gut microbiota, and changes in metabolic profiles related to caffeine metabolism.
  • - The findings suggest that specific gut bacteria are associated with inflammation levels, which may help in diagnosing and treating HICH effectively.
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Proinflammatory cytokines play a causal role in the development of hyperinsulinemia and T2MD. FOXO1, a transcription factor which is known to enhance proinflammation, was recently shown to be involved in obesity-induced cell dysfunction. However, molecular mechanisms for the association remained elusive.

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Objective: Graves' disease (GD) is one of the most common autoimmune conditions, but the mechanisms underlying the associated induction of autoimmunity are not known. We explored the role of peripheral lymphocyte subpopulations in disease pathogenesis.

Methods: In total, 32 patients and 40 age- and sex-matched healthy controls were recruited in this study.

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Background: Glioblastoma is one of the most common fatal intracranial malignancies. Lysine-specific demethylase 1 (LSD1) reportedly has therapeutic effects on a variety of tumors. This study explored the therapeutic effect of LSD1 inhibition on glioblastoma cell lines and the possible underlying mechanisms.

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