A Mendelian randomization study of serum uric acid with the risk of venous thromboembolism.

Background: Observational studies have linked hyperuricemia with venous thromboembolism (VTE). We aimed to investigate whether there are causal relationships between uric acid levels and VTE and its subtypes, including deep venous thrombosis (DVT) of the lower extremities and pulmonary embolism (PE).

Methods: We utilized Mendelian randomization (MR) analysis to estimate the causal association in European individuals.

Association of insomnia and daytime sleepiness with low back pain: A bidirectional mendelian randomization analysis.

Observational research has indicated the presence of a causal relationship between sleep disturbances and low back pain (LBP). However, the link may have been biased by confounding factors. The purpose of this study was to examine the potential causal association of insomnia and daytime sleepiness with LBP by using mendelian randomization (MR).