Di-(2-ethylhexyl)-phthalate disrupts mouse placental growth by regulating the cell cycle of mouse placental trophoblasts through the Trim38-p53 signaling axis.

Di-(2-ethylhexyl)-phthalate (DEHP) is a common endocrine disruptor that causes very serious environmental pollution. Recent studies have described that DEHP exerts detrimental effects on key processes of placental development, including implantation, differentiation, invasion, and angiogenesis. However, its effects on the proliferation of placental trophoblasts and related regulatory mechanisms remain elusive.

Lipidomic Analysis of Serum Lipid Profiles in Idiopathic Central Precocious Puberty and the Potential Regulatory Role of GnRHa in Lipid Metabolism.

Idiopathic central precocious puberty (ICPP) is an endocrine disorder increasingly observed in children, commonly treated with gonadotropin-releasing hormone agonists (GnRHa). However, the serum lipid profiles in girls with ICPP and the potential regulatory effects of GnRHa in lipid metabolism remain unclear. This research analyzed lipidomic profiles of serum samples from girls younger than 10 years of age, including 37 patients with ICPP, 32 ICPP patients treated with GnRHa, and 30 age-matched healthy controls.

Mitochondrial Genomes from Fungal the Entomopathogenic Genus Reveals Evolutionary History, Intron Dynamics and Phylogeny.

Members of the genus (Hypocreales, Clavicipitaceae) are insect pathogens with specificity for scale insects and whiteflies. However, no mitochondrial genomes are available for these fungi. Here, we assembled seven mitogenomes from , , , , , sp.

Preparation and Characterization of Lightweight, Hydrophobic, and Insulative Melamine Foam/Fumed Silica Composites.

Nanoparticulate silica is renowned for its excellent thermal insulation and low density; however, it faces challenges in practical applications due to high production costs and poor mechanical properties. In this study, a lightweight, hydrophobic, and insulative composite consisting of fumed silica and melamine foam (MF-FS) was prepared by using an atmospheric impregnation and drying process. Four different concentrations of fumed silica (5, 10, 15, and 20%) were systematically incorporated into the melamine foam to assess their effects on the composite's performance.

Distribution, removal and potential factors affecting antibiotics occurrence in leachate from municipal solid waste incineration plants in China.

Leachate from municipal solid waste (MSW) incineration harbors a plethora of contaminants, including antibiotics and antibiotic resistance genes (ARGs). However, the understanding of such leachate is markedly scant in comparison to that of landfill leachate. In this study, the distribution and removal of 8 sulfonamides (SAs), 4 quinolones (FQs), and 4 macrolides (MLs) antibiotics in leachate from 14 MSW incineration plants in representative cities across different regions of China were investigated.

Maternal exposure to bisphenol A induces congenital heart disease through mitochondrial dysfunction.

Congenital heart disease (CHD) represents a major birth defect associated with substantial morbidity and mortality. Although environmental factors are acknowledged as potential contributors to CHD, the underlying mechanisms remain poorly understood. Bisphenol A (BPA), a common endocrine disruptor, has attracted significant attention due to its widespread use and associated health risks.

Molecular Phylogenetics and Estimation of Evolutionary Divergence and Biogeography of the Family Cordycipitaceae (Ascomycota, Hypocreales).

The Cordycipitaceae family of insecticidal fungi is widely distributed in nature, is the most complex in the order Hypocreales (Ascomycota), with members displaying a diversity of morphological characteristics and insect host ranges. Based on Bayesian evolutionary analysis of five genomic loci(the small subunit of ribosomal RNA (SSU) gene, the large subunit of ribosomal RNA (LSU) gene, the translation elongation factor 1-α () gene, the largest subunit of RNA polymerase II (), and the second largest subunit of RNA polymerase II (), we inferred the divergence times for members of the Cordycipitaceae, improving the internal phylogeny of this fungal family. Molecular clock analyses indicate that the ancestor of occurred in the Paleogene period (34.

New Species of () from Diseased Leaves in Fujian Province, China.

Fungal biota represents important constituents of phyllosphere microorganisms. It is taxonomically highly diverse and influences plant physiology, metabolism and health. Members of the order are distributed worldwide and include devastating plant pathogens as well as endophytes and saprophytes.

BSA/PEI/GOD modified cellulose nanocrystals for construction of hydrogel-based flexible glucose sensors for sweat detection.

With the miniaturization, integration and intelligence of sweat electrochemical sensor technology, hydrogel flexible sensors have demonstrated immense potential in the field of real-time and non-invasive personal health monitoring. However, it remains a challenge to integrate excellent mechanical properties, self-healing properties, and electrochemical sensing capabilities into the preparation of hydrogel-based flexible sensors. The utilization of CBPG (cellulose nanocrystals (CNCs)@bovine serum albumin (BSA)@polyethyleneimine (PEI) glucose oxidase (GOD) nanomaterial) as both an enhancing phase and sensor probe within a hydrogel matrix, with poly(vinyl alcohol) (PVA) serving as the primary network constituent, has been proposed as a non-invasive technique for monitoring trace glucose levels in sweat.

Simultaneous Copper and EDTA Ligands Recovery from Electroless Effluent with Metallic Copper and Formaldehyde.

The traditional treatment of toxic and refractory copper(II)-ethylenediaminetetraacetic acid chelate (Cu(II)-EDTA) in electroless effluents often generates hazardous waste and secondary nitrogen-containing pollutants without maximizing the resource recovery. This study demonstrates a facile strategy to simultaneously recover Cu and EDTA ligands from Cu(II)-EDTA electroless effluent with commercially available metallic Cu and formaldehyde. In this strategy, metallic Cu is used to activate formaldehyde, a prevalent yet often overlooked cocontaminant in Cu(II)-EDTA effluents, to produce highly reductive hydrogen radical (H), which in situ decomplex Cu(II)-EDTA, reduces the central Cu(II) into metallic Cu, and release EDTA ligand.

Comparison of Clinical and Pathologic Features of Antimitochondrial Antibodies-negative Primary Biliary Cirrhosis and Cholestatic Type Drug-induced Liver Injury.

Aim: To compare the respective clinical and pathologic features of antimitochondrial antibodies-negative (AMA-negative) primary biliary cirrhosis (PBC) and cholestatic type drug-induced liver injury (DILI) for clinical differential diagnosis.

Patients And Methods: Clinical data from 23 patients with AMA-negative PBC and 39 patients with cholestatic type DILI, treated at our hospital between January 2013 and January 2024, were collected and retrospectively analyzed.

Results: The cholestatic type DILI group exhibited a higher incidence of malaise and abdominal pain compared with the AMA-negative PBC group.

Transnational Healthcare Practices Among Migrants: A Concept Analysis.

Aims: To present a conceptual definition of transnational healthcare in the context of migrant older adults.

Design: This article follows the Walker and Avant concept analysis framework to conduct an in-depth analysis of transnational healthcare.

Methods: Databases were searched for scholarly articles using keywords associated with transnational healthcare.

Unveiling the critical role of surface adsorbed oxygen species for efficiently photothermocatalytic oxidation of VOCs: Replenishing the active surface lattice oxygen sites.

Surface oxygen species play a crucial role in the photothermocatalytic oxidation of volatile organic compounds (VOCs), but their exact functions and evolutionary processes remain unclear. Herein, a series of spinel CoMnO catalysts are synthesized and employed for photothermocatalytic oxidation of toluene. CoMnO catalysts achieve 91.

Systemic mechanism of Panax noteginseng saponins in antiaging based on network pharmacology combined with experimental validation.

This study aims to investigate the systemic mechanism of Panax notoginseng saponins (PNS) in antiaging using network pharmacology combined with experimental validation. String database and Cytoscape3.7.

Antifreeze proteins and surface-modified cellulose nanocrystals for designing anti-freezing conductive hydrogel sensors.

Antifreeze proteins (AFPs) are a type of protein capable of inhibiting ice crystal growth, lowering the freezing point, and protecting organisms from cold-induced damage. In this study, cellulose nanocrystals (CNCs) are chemically modified to enhance the hydrogel's performance. The synergistic effect with AFPs further regulates its mechanical properties, antifreeze performance, and high sensing sensitivity.

Study on the anti-Parkinson's disease activity mechanism and preparation of panaxadiol.

Background: Traditional Chinese medicine offers unique and valuable resources for the exploration of novel approaches to disease treatment. Panaxadiol, an active compound derived from the transformation of ginsenosides. It has a variety of pharmacological activities.

[Quantifying the Carbon Reduction Difference Based on Households' Willingness to Transform Their Lifestyles from the Micro Perspective].

Cities are gathering places for residents, industries, and energy consumption, and the carbon emissions generated by urban residents' consumption are becoming increasingly prominent. Under the "dual carbon" goal, how to effectively guide the transformation of urban households' lifestyles and achieve consumption side carbon reduction has become an important issue. Based on questionnaire surveys and face-to-face interviews in the main districts of Hangzhou, the total amount and component of household consumption carbon reduction potential in Hangzhou were calculated by adopting a carbon emission coefficient model, and the relevant factors influencing various types of household consumption behaviors and carbon reduction potential were analyzed through virtual regression models and binary logistic regression.

Subregional parabolic conformal multi-order OAM-generating transmitarray with a novel C-I-shaped grating cell.

A parabolic conformal multi-order OAM-generating transmitarray with novel C-I-shaped grating cell is presented in this paper. The novel cell is composed of three layers of the upper and lower grating structures, and the C-I-shaped metal in the middle layer. Compared with the traditional C-shaped structure, the novel cell can be adjusted to cover 360° transmission phase change with high transmission coefficient at the frequency band of 10-20 GHz.

Di-(2-ethylhexyl) Phthalate Exposure Induces Developmental Toxicity in the Mouse Fetal Heart via Mitochondrial Dysfunction.

Congenital heart disease (CHD) is a major cause of infant mortality and morbidity, with growing interest in the role of environmental factors in its etiology. Di-(2-ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, has been implicated in the development of CHD. This study aimed to investigate the effects of DEHP exposure on fetal heart development in mice.

Integrating genomic profiling to clinical data: assessing the impact of CD147 expression on plaque stability.

Background: Acute Coronary Syndrome (ACS) continues to be a leading cause of death and illness worldwide. Differentiating stable from unstable coronary plaques is essential for enhancing patient outcomes. This research investigates the role of CD147 as a biomarker for plaque stability among coronary artery disease patients.

Psychological Wellbeing and Life Satisfaction among Chinese Older Immigrants in Canada across the Early and Late Stages of the COVID-19 Pandemic.

Objectives: This study compared the psychological wellbeing, life satisfaction, and perceived social support in Chinese older immigrants living in Canada between the early (i.e., Wave 1: September-November 2020) and late (i.

The Effects of Video Presence on Associative and Source Memory Among Younger and Older Adults in a Virtual Social Simulation.

The current study aimed to examine how video presence in a simulated virtual socialization meeting would affect younger ( = 60) and older adults' ( = 65) associative and source memory. Participants were instructed to watch a simulated virtual meeting where speakers introduced themselves with a name and an occupation, half with their video on and the other half with their video off. Participants completed a recognition test of intact, rearranged, and new name-occupation pairs.

miR-141-3p promotes paclitaxel resistance by attenuating ferroptosis via the Keap1-Nrf2 signaling pathway in breast cancer.

Breast cancer poses a huge threat to the lives and health of women worldwide. However, drug resistance makes the treatment of breast cancer challenging. This study aims to investigate the effect of miR-141-3p on paclitaxel resistance and its underlying mechanisms in breast cancer.