Nanoparticle-mediated light-driven LAMP combined with test strips for sensitive and rapid visual detection of antibiotic resistance genes.

Antibiotic resistance genes (ARGs) are markers of drug-resistant pathogens, monitoring them contributes to prevent resistance to drugs. The detection methods for ARGs including PCR and isothermal amplification are sensitive and selective. However, it may take several hours or cannot be used on spot.

Dual-Indicator loaded porous polymer microneedle patches for rapid and colorimetric detection of water-injected meat.

Water-injected meat leads to microbial growth, which affects the health of consumers. A colorimetric porous polymer microneedle patch was designed and prepared using photopolymerization of an acrylate monomer with porogen to be the substrate, and cobalt (II) chloride as color change indicator and tartrazine as the reference. The color of the microneedle patch changed from green to yellow green and to yellow as the increase of moisture concentration.

3D-Printed Hydrogel-Based Flexible Electrochromic Device for Wearable Displays.

Flexible electrochromic devices (FECDs) are widely explored for diverse applications including wearable electronics, camouflage, and smart windows. However, the manufacturing process of patterned FECDs remains complex, costly, and non-customizable. To address this challenge, a strategy is proposed to prepare integrated FECDs via multi-material direct writing 3D printing.

The lncRNA1-miR6288b-3p-PpTCP4-PpD2 module regulates peach branch number by affecting brassinosteroid biosynthesis.

Branch number is one of the most important agronomic traits of fruit trees such as peach. Little is known about how LncRNA and/or miRNA modules regulate branching through transcription factors. Here, we used molecular and genetic tools to clarify the molecular mechanisms underlying brassinosteroid (BR) altering plant branching.

Self-evolving persistent luminescence nanoprobes for autofluorescence-free ratiometric imaging and on-demand enhanced chemodynamic therapy of pulmonary metastatic tumors.

Precise imaging-guided therapy of a pulmonary metastasis tumor is of great significance for tumor management and prognosis. Persistent luminescence nanoparticles (PLNPs) are promising probes due to their excitation-free and low-background imaging characteristics. However, most of the PLNP-based probes cannot intelligently distinguish between normal and tumor tissues or balance the needs of targeted accumulation and rapid metabolism, resulting in false positive signals and potential side effects.

Persistent production of multiple active species with copper doped zinc gallate nanoparticles for light-independent photocatalytic degradation of organic pollutants.

Photocatalysis is considered as an environmentally friendly and sustainable method as it can produce active species to degrade pollutants. However, its applications are hindered by the turbidity of pollutants and the requirements for continuous or repeated in situ irradiation. To avoid the need for continuous in situ irradiation in the photocatalytic process, herein we report the doping of Cu(II) ions into zinc gallate (ZnGaO) as traps to capture photo-generated electrons.

Automated Breast Volume Scanner Is More Valuable Than Hand-Held Ultrasound in Diagnosis of Small Breast cancer: An Analysis of 725 Patients With 912 Lesions Evaluations.

This study aimed to evaluate the clinical value of automated breast volume scanner (ABVS) compared with hand-held ultrasound (HHUS). From January 2015 to May 2019, a total of 912 breast lesions in 725 consecutive patients were included in this study. κ statistics were calculated to identify interobserver agreement of ABVS and HHUS.

Size-independent boosting of near-infrared persistent luminescence in nano-phosphors via a magnesium doping strategy.

Near-infrared (NIR)-emitting persistent luminescence nanoparticles (PLNPs) are ideal optical imaging contrast reagents characterized by autofluorescence-free optical imaging for their frontier applications in long-term bioimaging. Preparation of uniform small-sized PLNPs with excellent luminescence performance is crucial for biomedical applications, but challenging. Here, we report a facile magnesium doping strategy to achieve size-independent boost of NIR persistent luminescence in typical and most concerned ZnGaO:Cr PLNPs.

A conditional inference tree model for predicting cancer risk of non-mass lesions detected on breast ultrasound.

Objectives: To generate and validate a prediction model based on imaging features for cancer risk of non-mass lesions (NMLs) detected on breast ultrasound (US).

Methods: In this single-center study, consecutive women with 503 NMLs detected on breast US between 2012 and 2019 were retrospectively identified. The lesions were randomly assigned to the training or testing dataset with a 70/30 split.

Treating Severe Adverse Drug Reactions Caused by Ischemic Optic Neuropathy with Ginkgo Biloba Extract Injection: A Case Report.

Background: Ginkgo biloba extract preparations are commonly used in ophthalmology to improve circulatory disorders and provide neurotrophic support for the treatment of optic neuropathy. However, their use also carries a higher risk of adverse drug reactions (ADRs), some of which can be severe and even life-threatening, such as anaphylactic shock. This case report highlights the importance of recognizing and managing ADRs associated with ginkgo biloba extract in ophthalmology clinical practice.

Clinical Effect Evaluation of Concentrated Growth Factor in Endodontic Microsurgery: A Cross-Sectional Study.

Introduction: Concentrated growth factor (CGF) is the third-generation platelet concentrate product. This study aimed to evaluate whether the use of CGF during endodontic microsurgery had a positive influence on surgical outcomes.

Methods: Fifty-four patients who underwent endodontic microsurgery from January 2017 to November 2021 were enrolled.

is upregulated by lncRNA5 and controls branch number in peach () through positive feedback regulation of strigolactone biosynthesis.

Branch number is an important agronomic trait in peach () trees because plant architecture affects fruit yield and quality. Although breeders can select varieties with different tree architecture, the biological mechanisms underlying architecture remain largely unclear. In this study, a pillar peach ('Zhaoshouhong') and a standard peach ('Okubo') were compared.

The Potential Immunomodulatory Roles of Semaphorin 4D in Human Periapical Lesions.

Introduction: Semaphorin 4D (SEMA4D) is an important immunoregulator in the development of inflammatory diseases. Currently, the role of SEMA4D in human apical periodontitis remains unclear. This study aims to investigate the expression of SEMA4D and its potential immunomodulatory roles in apical periodontitis.

Adaptive Orbital Rendezvous Control of Multiple Satellites Based on Pulsar Positioning Strategy.

This paper addresses the orbital rendezvous control for multiple uncertain satellites. Against the background of a pulsar-based positioning approach, a geometric trick is applied to determine the position of satellites. A discontinuous estimation algorithm using neighboring communications is proposed to estimate the target's position and velocity in the Earth's Centered Inertial Frame for achieving distributed rendezvous control.

Quantitative Indicators of Retraction Phenomenon on an Automated Breast Volume Scanner: Initial Study in the Diagnosis and Prognostic Prediction of Breast Tumors.

Retraction phenomenon is a unique sign on an automated breast volume scanner coronal plane image and has high specificity in differentiating benign lesions from malignant breast cancer. The purpose of this study was to quantify the retraction phenomenon by setting different rules to describe connected regions from different dimensions. In total, six quantitative indicators (F,F,F,F,Fand F) were obtained.

A pH-Responsive Persistent Luminescence Nanozyme for Selective Imaging and Killing of and Common Resistant Bacteria.

() infection is implicated in the etiology of many diseases. eradication by antibiotic therapy is limited by the extreme acidic environment in the stomach, the undesired side effect of intestinal commensal bacteria, and the development of drug resistance. Here, we report a pH-responsive persistent luminescence (PL) nanozyme (MSPLNP-Au-CB) for in vivo imaging and inactivation of .

Efficacy of Individualized Preventive Treatment of Patients with Severe Hemophilia A Guided by Multiple Clinical Parameters and Pharmacokinetics.

Objective: The objective of the study was to investigate the effect of multiple clinical parameters (age, weight, blood types, and bleeding types) on FVIII pharmacokinetic parameters (PK parameters) in adult patients with severe hemophilia A (SHA), draw up individualized preventive treatment plans, and observe clinical efficacy.

Methods: Forty SHA patients treated in our hospital from January 2018 to May 2019 were enrolled, with their age, weight, blood types, bleeding types, and PK parameters measured to analyze the effects of clinical parameters on PK parameters. Individualized preventive treatment was developed, and patients were followed up for 1 year.

Responsive nanoplatform for persistent luminescence "turn-on" imaging and "on-demand" synergistic therapy of bacterial infection.

Multifunctional nanotheranostic platforms are emerging for the treatment of bacterial infections. Uncontrollable drug release and poor response in target location leads to inefficient therapy and failure to offer timely antibacterial monitoring. Here, we report a multifunctional nanoplatform that can be triggered by the bacterial microenvironment for effective bacterial killing and high-sensitive persistent luminescence (PL) "turn-on" imaging.

Piezoelectric Nanogenerator for Highly Sensitive and Synchronous Multi-Stimuli Sensing.

Smart sensors are expected to be sustainable, stretchable, biocomfortable, and tactile over time, either in terms of mechanical performance, reconfigurability, or energy supply. Here, a biocompatible piezoelectric electronic skin (PENG) is demonstrated on the base of PZT-SEBS (lead zirconate titanate and styrene ethylene butylene styrene) composite elastomer. The highly elastic (with an elasticity of about 950%) PENG can not only harvest mechanical energy from ambient environment, but also show low toxicity and excellent sensing performance toward multiple external stimuli.

X-ray Pulsar Signal Denoising Based on Variational Mode Decomposition.

Pulsars, especially X-ray pulsars detectable for small-size detectors, are highly accurate natural clocks suggesting potential applications such as interplanetary navigation control. Due to various complex cosmic background noise, the original pulsar signals, namely photon sequences, observed by detectors have low signal-to-noise ratios (SNRs) that obstruct the practical uses. This paper presents the pulsar denoising strategy developed based on the variational mode decomposition (VMD) approach.

lncRNA NEAT1 Facilitates Cell Proliferation, Invasion and Migration by Regulating CBX7 and RTCB in Breast Cancer.

Purpose: To investigate the association between the lncRNA NEAT1 and breast cancer, and to determine the influence of NEAT1 on regulation of other signaling molecules in breast cancer.

Methods: In the present study, we measured levels of the lncRNA NEAT1 in 106 breast cancer patients and in a human breast cancer cell line by qRT-PCR. The correlation between NEAT1 expression and patients' clinical characteristics was analyzed with in-house and TCGA data.