Anti-C1q antibodies and IgG subclass distribution in sera from Chinese patients with lupus nephritis.

Unlabelled: Objective. Anti-C1q antibodies are common in sera from patients with lupus nephritis (LN) and are associated with disease activity. The current study aimed to further investigate the prevalence of serum IgG anti-C1q antibody, its subclass distribution and their clinical and pathological association in patients with LN.

The level of serum secretory IgA of patients with IgA nephropathy is elevated and associated with pathological phenotypes.

Background: Mucosal infection associated episodic macroscopic haematuria is observed in many patients with IgA nephropathy (IgAN), however, the mechanism has not been elucidated. Recent study suggested that secretory IgA (SIgA) might play an important role in the pathogenesis of IgAN. The aim of this study is to investigate the level of serum SIgA and the deposition of SIgA in glomeruli in IgAN patients with different pathological phenotypes.

Aberrant sialylation of serum IgA1 was associated with prognosis of patients with IgA nephropathy.

Aberrant glycosylation of serum IgA1 was considered as an initial event and involvement in the pathogenesis of IgAN. We previously demonstrated that aberrant glycosylation of serum IgA1 was associated with pathologic phenotype of IgAN. The present study is to investigate if abnormal sialylation of IgA1 affects renal survival of IgAN.

[Dental caries in children with cleft lip and/or palate in China].

Objective: To determine the prevalence of dental caries in children with cleft lip and Palate.

Methods: A cross-sectional study was undertaken in 380 children with cleft lip and Palate and 339 children without cleft. Dental caries were measured with decayed-missing-filed-teeth index (DMFT/dmft) and the decayed-missing-filed-surface index (DMFS/dmfs).

Binding capacity of in vitro deglycosylated IgA1 to human mesangial cells.

IgA nephropathy (IgAN) is the most common glomerular disease and it is characterized by deposition of IgA1 molecules in mesangium. Recent studies had demonstrated that serum and mesangial IgA1 in IgAN were deglycosylated and IgA1 could bind to human mesangial cells (HMC) through a novel receptor. The aim of the current study is to investigate and compare the binding capacities of different in vitro deglycosylated IgA1 on human mesangial cells.

Aberrantly glycosylated serum IgA1 are closely associated with pathologic phenotypes of IgA nephropathy.

Background: IgA nephropathy (IgAN) is the most common glomerulonephritis with various histologic and clinical phenotypes. The mechanisms underlying the pathogenesis of IgAN remained unclear. But now altered O-glycosylation of serum IgA1 observed in these patients was considered to be a key contributory factor.

[Synthesis and photoluminescence properties of Tb(3+) -acetylacetone ternary complexes doped with La3+ or Y3+].

Four series of solid complexes including RE(x) Tb(1-x) (acac)3 phen and RE(x) Tb(1-x) (acac)3 bipy (RE = La, Y; x = 0, 0.10, 0.20, 0.

[Binding capacity of aberrantly glycosylated serum IgA1 with human umbilical vein endothelial cells].

Objective: To investigate the binding capacities of differently glycosylated IgA1 on human umbilical vein endothelial cells (HUVEC).

Methods: Serum IgA1 was purified by jacalin affinity chromatography and then was desialylated and/or degalactosylated with neuraminidase and/or beta-galactosidase respectively. The efficacy of deglycosylations were assessed by peanut agglutinin (PNA) and vicia villosa lectin (VVL).