tsRNA-3043a intensifies apoptosis and senescence of ovarian granulosa cells to drive premature ovarian failure by targeting FLT1.

Premature ovarian failure (POF) represents the pathological aging of the ovary. The tRNA-derived small fragments (tsRNAs) play significant roles in diseases; however, whether tsRNAs are involved in POF remains unknown. The cell and mice models of POF were established, and the tsRNAs profile in the ovarian tissues of POF mice was revealed through sequencing.

Study on Low-Temperature and Fatigue Performance of High RAP Content Hot Recycled Asphalt Mixture Based on the Degree of Blending (DOB).

This paper selected three kinds of AC-20 hot-mix recycled asphalt mixtures with high RAP content (30%, 40%, and 50%). It obtains a mixture of different degrees of miscibility by changing RAP preheating temperatures and mixing temperatures. The calculation formula of the degree of blending (DOB) of RAP asphalt interface recycling is proposed.

Proteomics analysis of cancer tissues identifies IGF2R as a potential therapeutic target in laryngeal carcinoma.

Background: Laryngeal cancer (LC) is a prevalent head and neck malignancy; however, the essential pathophysiological mechanism underlying its tumorigenesis and progression remains elusive. Due to the perduring scarcity of effective targeted drugs for laryngeal cancer, insights into the disease's pathophysiological mechanisms would substantially impact the treatment landscape of laryngeal cancer.

Methods: To ensure quality consistency, 10 tumor and 9 non-tumor samples underwent proteomic analysis on a single mass spectrometer using a label-free technique.

Camouflage versus running performance as strategies against predation in a lizard inhabiting different habitats.

Running speed and camouflage are associated with the foraging and anti-predator abilities of animals. The toad-headed lizard, , has evolved a darker dorsal color in melanistic habitats and maintained a lighter color in adjacent, non-melanistic habitats. We test the hypothesis that lizards have weaker running speed on well-matching backgrounds than on less matching backgrounds.

Aptamer Detection of Mannose-Capped Lipoarabinomannan in Lesion Tissues for Tuberculosis Diagnosis.

Tuberculosis (TB) is the leading infectious cause of mortality worldwide. However, the diagnosis of TB, especially extrapulmonary TB (EPTB) diagnosis from lesion tissues, remains a challenge. Nucleic acid aptamers are analogous to antibodies and have advantages of easier modification, high specificity, and affinity.

High-intensity focused ultrasound for the treatment of allergic rhinitis using nasal endoscopy.

The present study aimed to observe the therapeutic effect of high-intensity focused ultrasound for the treatment of allergic rhinitis (AR) using nasal endoscopy. A total of 72 patients with perennial AR received treatment using the CZB ultrasonic therapeutic instrument with nasal endoscopy. A scoring method was adopted for evaluation of effectiveness according to the AR therapeutic principles and recommendations described in Allergic Rhinitis and its Impact on Asthma (ARIA) in 2001.