Calcium Alginate Fibers/Boron Nitride Composite Lithium-Ion Battery Separators with Excellent Thermal Stability and Cycling Performance.

As one of the most critical components in lithium-ion batteries (LIBs), commercial polyolefin separators suffer from drawbacks such as poor thermal stability and the inability to inhibit the growth of dendrites, which seriously threaten the safety of LIBs. In this study, we prepared calcium alginate fiber/boron nitride-compliant separators (CA@BN) through paper-making technology and the surface coating method using calcium alginate fiber and boron nitride. The CA@BN had favorable electrolyte wettability, flame retardancy, and thermal dimensional stability of the biomass fiber separator.

Flexible composite film utilizing VO self-adaptive photothermal and infrared radiative cooling for continuous energy harvesting.

Self-adaptive photothermal (PT) and radiative cooling (RC) based on insulation-metal phase transition vanadium dioxide (VO) are among the most promising continuous energy harvesting technologies recently. However, previous work relies on rigid substrates that cannot fit complex or non-planar surfaces. Here, we propose a flexible composite film by bonding a VO thin film and a polyimide (PI) substrate with polymethyl methacrylate (PMMA), which achieves efficient spectrally self-adaptive broadband absorption/emission and can convert between the daytime PT mode and nighttime RC mode.

Electronic Structure Regulated Nickel-Cobalt Bimetal Phosphide Nanoneedles for Efficient Overall Water Splitting.

Transition metal phosphides (TMPs) have been widely studied for water decomposition for their monocatalytic property for anodic or cathodic reactions. However, their bifunctional catalytic activity still remains a major challenge. Herein, hexagonal nickel-cobalt bimetallic phosphide nanoneedles with 1-3 μm length and 15-30 nm diameter supported on NF (NiCoP NDs/NF) with adjusted electron structure have been successfully prepared.

Risk factors for renal outcomes in children with antineutrophil cytoplasmic antibody-associated vasculitis: a nationwide retrospective study in China.

Background: Pediatric antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a life-threatening systemic vasculitis featured by liability to renal involvement. However, there are few studies on the risk factors and predictive models for renal outcomes of AAV in children.

Methods: Data from 179 AAV children in multiple centers between January 2012 and March 2020 were collected retrospectively.

Backscattering enhancements by partially exposed spheres due to reflected subsonic Rayleigh waves at air-water interfaces.

Air-water interfaces can enable distinct target scattering mechanisms different from the mechanism under free field conditions. In this study, backscattering experiments are performed by lowering an acrylic or polymethylmethacrylate sphere through the air-water interface into the water and insonifying the sphere from below at grazing incidence. Pronounced backscattering enhancements associated with the subsonic Rayleigh wave propagation mechanism are observed before the specular reflection point of the sphere reaches the water.

Psychosocial crisis intervention for coronavirus disease 2019 patients and healthcare workers.

Objectives: Shelter hospital was an alternative way to provide large-scale medical isolation and treatment for people with mild coronavirus disease 2019 (COVID-19). Due to various reasons, patients admitted to the large shelter hospital was reported high level of psychological distress, so did the healthcare workers. This study aims to introduce a comprehensive and multifaceted psychosocial crisis intervention model.

Prevalence and risk factors of thyroid dysfunction in outpatients with overweight or obese first-episode and drug-naïve major depressive disorder.

Background: Thyroid dysfunction is common in patients with major depressive disorder (MDD). However, few studies have examined risk factors for thyroid dysfunction in overweight or obese first-episode and drug-naïve (FEDN) MDD patients. This study aimed to investigate the prevalence and risk factors of thyroid dysfunction in FEDN MDD patients with comorbid high body mass index (BMI).

Prevalence and factors associated with anxiety and depression among community-dwelling older adults in Hunan, China: a cross-sectional study.

Background: Older adults' psychological health is a public health issue that cannot be ignored, especially when these psychological health problems and related factors change across different social backgrounds because of rapid changes in traditions and family structures and the epidemic responses after the outbreak of COVID-19 in China. The aim of our study is to determine the prevalence of anxiety and depression and their associated factors among community-dwelling older adults in China.

Methods: A cross-sectional study was conducted from March to May 2021 with 1173 participants aged 65 years or above from three communities in Hunan Province, China who were selected using convenience sampling.

Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer's disease.

Background: Neuroinflammatory factors, especially chemokines, have been widely reported to be involved in the pathogenesis of Alzheimer's disease (AD). It is unclear how chemokines are altered in AD, and whether dysregulation of chemokines is the cause, or the consequence, of the disease.

Methods: We initially screened the transcriptomic profiles of chemokines from publicly available datasets of brain tissues of AD patients and mouse models.

Biotransformation of the saponins in Panax notoginseng leaves mediated by gut microbiota from insomniac patients.

Saponins extracted from Panax notoginseng leaves by methanol or water could be orally administrated for insomnia with very low bioavailability, which might be bio-converted by gut microbiota to generate potential bioactive products. Moreover, gut microbiota profiles from insomniac patients are very different from healthy subjects. We aimed to compare the metabolic characteristics and profiles of the two saponins extract by incubation with gut microbiota from insomniac patients.

The Role of Total White Blood Cell Count in Antipsychotic Treatment for Patients with Schizophrenia.

Background: Total white blood cell count (TWBCc), an index of chronic and low-grade inflammation, is associated with clinical symptoms and metabolic alterations in patients with schizophrenia. The effect of antipsychotics on TWBCc, predictive values of TWBCc for drug response, and role of metabolic alterations require further study.

Methods: Patients with schizophrenia were randomized to monotherapy with risperidone, olanzapine, quetiapine, aripiprazole, ziprasidone, perphenazine or haloperidol in a 6-week pharmacological trial.

Common and rare variants of EGF increase the genetic risk of Alzheimer's disease as revealed by targeted sequencing of growth factors in Han Chinese.

Alzheimer's disease (AD) is the most common neurodegenerative disease with high heritability. Growth factors (GFs) might contribute to the development of AD due to their broad effects on neuronal system. We herein aimed to investigate the role of rare and common variants of GFs in genetic susceptibility of AD.

Early Efficacy of Antipsychotic Medications at Week 2 Predicts Subsequent Responses at Week 6 in a Large-scale Randomized Controlled Trial.

Background: Since the early clinical efficacy of antipsychotics has not yet been well perceived, this study sought to decide whether the efficacy of antipsychotics at week 2 can predict subsequent responses at week 6 and identify how such predictive capacities vary among different antipsychotics and psychotic symptoms.

Methods: A total of 3010 patients with schizophrenia enrolled in a randomized controlled trial (RCT) and received a 6-week treatment with one antipsychotic drug randomly chosen from five atypical antipsychotics (risperidone 2-6 mg/d, olanzapine 5-20 mg/d, quetiapine 400-750 mg/d, aripiprazole 10-30 mg/d, and ziprasidone 80-160 mg/d) and two typical antipsychotics (perphenazine 20-60 mg/d and haloperidol 6-20 mg/d). Early efficacy was defined as the reduction rate using the Positive and Negative Syndrome Scale (PANSS) total score at week 2.

Ultrastable and High-Rate 2D Siloxene Anode Enabled by Covalent Organic Framework Engineering for Advanced Lithium-Ion Batteries.

Siloxene as a new type of 2D material has wide potential applications due to its special structure. Especially, as anode for lithium-ion batteries, siloxene shows promising prospect due to its small volume change and low diffusion pathway. However, the unstable solid electrolyte interphase and low electronic conductivity lead to the low Coulombic efficiency, poor rate capability, and limited cycling performance.

A novel FOXP3 mutation in a Chinese child with IPEX-associated membranous nephropathy.

Background: Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a monogenic immunodeficiency disease caused by forkhead box protein3 (FOXP3) mutation. The kidney is commonly involved in IPEX syndrome, but there were few studies focusing on renal involvement.

Methods: Whole-exome sequencing was used to identify the novel FOXP3 mutation.

Full color 3D printing of anatomical models.

We propose an effective method for manufacturing human anatomical specimens in response to the shortage of cadaver specimens and the poor simulation results of anatomical specimen substitutes. Digital human data with high precision were used to create digital models and corresponding mapped textures. Different materials were chosen to print the digital models with full-color and multimaterial 3D-printing technology based on the histological characteristics of the anatomical structures.

Abnormalities of Electroencephalography Microstates in Drug-Naïve, First-Episode Schizophrenia.

Objective: Microstate analysis is a powerful tool to probe the brain functions, and changes in microstates under electroencephalography (EEG) have been repeatedly reported in patients with schizophrenia. This study aimed to investigate the dynamics of EEG microstates in drug-naïve, first-episode schizophrenia (FE-SCH) and to test the relationship between EEG microstates and clinical symptoms.

Methods: Resting-state EEG were recorded for 23 patients with FE-SCH and 23 healthy controls using a 64-channel cap.

Mental Health Differences in Healthcare Workers Exposed to Different Risks During the Coronavirus Disease 2019 Pandemic.

Background: The coronavirus disease 2019 (COVID-19) pandemic has caused a significant impact on the physical and mental health of healthcare workers. This study assessed the psychological status of healthcare workers who were exposed to different risk-levels in China and explored the factors that affected their mental health.

Methods: Demographic, occupational characteristics, and mental health measurements were collected from 810 workers in 41 hospitals in China, through online questionnaires from February 11 to March 3, 2020.

MXene/Organics Heterostructures Enable Ultrastable and High-Rate Lithium/Sodium Batteries.

Organic electrode materials have shown potential for rechargeable batteries because they are environmentally friendly, earth-abundant sources, recyclable, high sustainable, designable, flexible, and lightweight. However, low electrical conductivity and dissolution in organic liquid electrolytes hinder their further development. Herein, MXene/organics heterostructures are designed to address the problems of organic electrodes via a scalable and simple electrostatic self-assembly strategy.

Covalent Organic Frameworks and Their Derivatives for Better Metal Anodes in Rechargeable Batteries.

Metal anodes based on a plating/stripping electrochemistry such as metallic Li, Na, K, Zn, Ca, Mg, Fe, and Al are recognized as promising anode materials for constructing next-generation high-energy-density rechargeable metal batteries owing to their low electrochemical potential, high theoretical specific capacity, superior electronic conductivity, . However, inherent issues such as high chemical reactivity, severe growth of dendrites, huge volume changes, and unstable interface largely impede their practical application. Covalent organic frameworks (COFs) and their derivatives as emerging multifunctional materials have already well addressed the inherent issues of metal anodes in the past several years due to their abundant metallophilic functional groups, special inner channels, and controllable structures.

Inhibitory Top-Down Control Deficits in Schizophrenia With Auditory Verbal Hallucinations: A Go/NoGo Task.

Auditory verbal hallucinations (AVH), with unclear mechanisms, cause extreme distresses to schizophrenia patients. Deficits of inhibitory top-down control may be linked to AVH. Therefore, in this study, we focused on inhibitory top-down control in schizophrenia patients with AVH.