Correlation between 25-hydroxyvitamin D and severe headache or migraine: evidence from NHANES database.

Objective: This study was formulated with the objective of elucidating the correlation between 25-hydroxyvitamin D (25(OH)D) and the occurrence of severe headache or migraine, employing a cross-sectional analytical approach.

Methods: A cross-sectional survey was conducted over two cycles involving 7,661 participants, utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2004. A weighted logistic regression method was employed to construct a relationship model between the two variables.

LncRNA gene polymorphisms and their influence on lung cancer patients in the Chinese Han population.

Lung cancer is primarily classified as NSCLC, which is distinguished by a wide range of genetic variations. This study focused on , a relatively unexplored lncRNA, to explore the impact of its genetic polymorphisms on the susceptibility to NSCLC. We detected expression and its correlation with prognosis and clinical pathological features using bioinformatics analysis.

Impact of Chondroitin Sulfate Proteoglycan 4 Pseudogene 12 Genetic Variants on Colorectal Cancer Risk: A Case-Control Study.

This study aims to investigate the correlation between the chondroitin sulfate proteoglycan 4 pseudogene 12 () polymorphism and the risk of colorectal cancer (CRC). This case-control study involved 850 patients with CRC and 850 health controls. The genotypes of (rs2880765, rs6496932, and rs8040855) were determined by the TaqMan-MGB probe method.

Turnover intention and its related factors of clinical research coordinator in Hunan, China: a cross-sectional study.

To explore the related factors of turnover intention in clinical research coordinators (CRCs) and assess the mediating effects of professional identity on the association between job burnout and turnover intention. In China, CRC has become increasingly common among clinical trial teams in recent years. However, limited published research focused on the status of turnover intention in CRCs.

Highly Dispersed Pd-CeO Nanoparticles in Zeolite Nanosheets for Efficient CO-Mediated Hydrogen Storage and Release.

Formic acid (FA) dehydrogenation and CO hydrogenation to FA/formate represent promising methodologies for the efficient and clean storage and release of hydrogen, forming a CO-neutral energy cycle. Here, we report the synthesis of highly dispersed and stable bimetallic Pd-based nanoparticles, immobilized on self-pillared silicalite-1 (SP-S-1) zeolite nanosheets using an incipient wetness co-impregnation technique. Owing to the highly accessible active sites, effective mass transfer, exceptional hydrophilicity, and the synergistic effect of the bimetallic species, the optimized PdCe/SP-S-1 catalyst demonstrated unparalleled catalytic performance in both FA dehydrogenation and CO hydrogenation to formate.

Analysis of the Effect of Rapid Rehabilitation Nursing in the Perioperative Period of Brucellar Spondylitis.

Objective: To explore the effect of rapid rehabilitation nursing in patients with brucellar spondylitis during the perioperative period.

Methods: A total of 68 patients with brucellar spondylitis who underwent surgical treatment in our hospital from August 2019 to May 2022 and met the inclusion criteria were enrolled as study subjects. The patients were divided into a conventional group and a rehabilitation group with 34 cases each according to different nursing methods.

Chinese expert consensus on transradial access in percutaneous peripheral interventions.

Transradial access (TRA) is a safe and comfortable approach and the preferred access for percutaneous coronary intervention. However, TRA is not widely used for peripheral interventions. Currently, there is a lack of data on patient selection, appropriate medical devices, complication prevention, and TRA adoption.

Study on the Coal-Oxygen Intrinsic Reaction at Low Temperature by the Subtraction Method.

Coal oxidation involves complex physical and chemical processes as well as many reaction pathways. The subtraction method was used to investigate the law of the coal-oxygen intrinsic reaction at low temperatures. The subtraction method is to subtract the characteristic curve of the coal reaction in N from the characteristic curve of coal oxidation in air, which can remove the influence of pyrolysis reaction, water evaporation, and gas desorption on coal low-temperature oxidation, and ultimately obtain the coal-oxygen intrinsic reaction curve under the pure oxidation pathway.

The effect of exposure to COVID-19 on life satisfaction: The mediating role of hyperarousal and moderating/mediating role of affective forecasting.

Background: As a global trauma event, the Coronavirus disease (COVID-19) hugely impacts people's mental health and well-being. The purpose of our study is threefold: first, investigate the relationship between exposure to COVID-19 and life satisfaction among a large sample in China; second, test the mediating role of hyperarousal in the association between exposure to COVID-19 and life satisfaction; third, explore the moderating/mediating role of affective forecasting in the association between hyperarousal and life satisfaction.

Method: The current study recruited 5546 participants to complete a set of self-report questionnaires online from April 22, 2020 to April 24, 2020.

PBX1-promoted SFRP4 transcription inhibits cell proliferation and epithelial-mesenchymal transition in endometrial carcinoma.

Objective: To explore the effects and mechanisms of action of the PBX1/secreted frizzled-related protein 4 (SFRP4) axis in endometrial carcinoma (EC).

Methods: The expression of PBX1 and SFRP4 was analyzed using bioinformatics prediction, followed by validation in EC cells using quantitative reverse transcription-polymerase chain reaction and western blotting. After transduction with overexpression vectors for PBX1 and SFRP4, migration, proliferation, and invasion of EC cells were measured, accompanied by the detection of E-cadherin, Snail, N-cadherin, Vimentin, β-catenin, GSK-3β, and C-myc expression.

Investigation of Competitive Adsorption Properties of CO/CO/O onto the Kailuan Coals by Molecular Simulation.

To reveal the CO, CO, and O adsorption properties of two bituminous coals at different pressures and temperatures, the molecular unit-cell structures of two types of bituminous coal are constructed (CHON and CHON) by Fourier transform infrared (FTIR) spectroscopy. The bituminous coal molecular FTIR spectroscopic curve is calculated by quantum chemistry, and the results are consistent with the experimental curve. The isothermal adsorption curves of the single-component gases CO, CO, and O conform to the Langmuir equation from 20 to 60 °C.

Establishment, characterization, and transfection potential of a new continuous fish cell line (CAM) derived from the muscle tissue of grass goldfish (Carassius auratus).

A new continuous fish cell line (CAM) has been successfully derived from the muscle tissues of grass goldfish, Carassius auratus. The primary cell cultures were initiated by incomplete trypsinization first and then explant culture in a Leibovitz-15 medium supplemented with 15% fetal bovine serum and 10% fish muscle extract. It was found that the CAM cells were very sensitive to trypsinization and needed to be sub-cultured at a low trypsin concentration of 0.

Risk factors of uterine contraction after ureteroscopy in pregnant women with renal colic.

Background: Ureteroscopy is widely applied in pregnant women with renal colic, but such patients are easy to experience uterine contraction after surgery. There are many factors which may affect uterine contraction, this study aims to explore the risk factors of uterine contraction triggered by ureteroscopy in pregnant women with renal colic.

Methods: One hundred and one pregnant women were retrospectively analyzed, the patients were hospitalized because of severe renal colic.

Chemotherapy-Induced Nausea and Vomiting in Breast Cancer Patients: A Multicenter Prospective Observational Study.

Objective: This study aimed to assess the occurrence of chemotherapy-induced nausea and vomiting (CINV) in acute phase (24 h after chemotherapy) and delayed phase (2-5 days after chemotherapy) after standard antiemetic therapy and to explore the risk factors of CINV in the acute and delayed phases.

Methods: This prospective and observational study analyzed the data of 400 breast cancer patients scheduled for chemotherapy in two hospitals. The self-report survey was developed to assess the occurrence of CINV and their associated factors.

Study on the Spontaneous Combustion Tendency of Coal Based on Grey Relational and Multiple Regression Analysis.

The correlation between the spontaneous combustion tendency of coal and its properties are of great importance for safety issues, environmental concerns, and economic problems. In this study, the relationship between multiple parameters, different from the previous single parameter, and the spontaneous combustion tendency was analyzed. The comprehensive judgment index (CJI), which indicates the tendency of coal spontaneous combustion, was obtained for samples collected from different mines.

Atorvastatin potentiates the chemosensitivity of human liver cancer cells to cisplatin via downregulating YAP1.

Atorvastatin is a competitive inhibitor of β-hydroxy β-methylglutaryl-CoA reductase, which is involved in anticancer effects in numerous types of cancer, including in human liver cancer. However, its functions and underlying mechanisms of chemosensitivity in liver cancer remain to be elucidated. The present study investigated the effect of atorvastatin on cisplatin chemosensitivity and its molecular mechanisms, with a focus on the Yes1-associated transcriptional regulator (YAP1) protein.

Targeting Yes1 Associated Transcriptional Regulator Inhibits Hepatocellular Carcinoma Progression and Improves Sensitivity to Sorafenib: An in vitro and in vivo Study.

Purpose: The aim of this study was to investigate the role of Yes1 associated transcriptional regulator (YAP1) in the pathology of hepatocellular carcinoma (HCC) and its potential as a therapeutic target.

Methods: YAP1 expression in HCC and adjacent tissues was determined via immunohistochemistry; in HCC and human normal liver cell lines, expression was examined via Western blotting. The effects of YAP1 knockdown and overexpression were detected following transfection of HCC cells with siRNA-YAP1 recombinants or pcDNA3.

Reprogrammed CRISPR-Cas13a targeting the HPV16/18 E6 gene inhibits proliferation and induces apoptosis in E6-transformed keratinocytes.

The long-lasting infection of high-risk type (type 16 or type 18) human papillomavirus (HPV) is the main cause of gynecological and urinary malignancies. Given the high mortality rate after surgery, the development of a new molecular therapy would be of value to clinicians. The aim of the present study was to achieve targeted inactivation of the viral E6 gene in keratinocytes using the reprogrammed CRISPR-Cas13a system.

Evaluation of Percutaneous Mechanical Thrombectomy via the AngioJet System Combined with Catheter-Directed Thrombolysis for the Treatment of Symptomatic Lower Extremity Deep Venous Thrombosis.

Background: Current methods of treating lower extremity deep venous thrombosis (LEDVT), such as catheter-directed thrombolysis (CDT) alone, or percutaneous mechanical thrombectomy (PMT) alone, are accompanied by unacceptably high risks of complications. This preliminary retrospective study evaluated the efficacy of CDT combined with PMT (via the AngioJet system), relative to CDT alone, in treating LEDVT.

Methods: Forty-two patients (43 limbs) with symptomatic deep venous thrombosis received either CDT alone (n = 12) or PMT combined with CDT (PMT + CDT) from May 2012 to December 2016.

I suppressed the Warburg effect viaregulating miR-338/PFKL axis in hepatocellular carcinoma.

Objectives: Iodine-125 (I) irradiation has been widely applied in the treatment of advanced multiple malignant tumors. However, the underlying mechanism of I exerted an anti-tumor effect on hepatocellular carcinoma (HCC) was largely unknown.

Methods: In both HCCLM3 and SMMC-7721 cells, the effect of I irradiation on the glycolysis was detected.

Electromagnetic navigation to assist with computed tomography-guided thermal ablation of liver tumors.

To evaluate the advantages and primary technical efficacy of an electromagnetic (EM) navigation system for computed tomography (CT)-guided thermal ablation of liver tumors. From August 2016 to January 2018, 40 patients scheduled for CT- guided thermal ablation were prospectively enrolled and divided into two groups. Twenty patients underwent CT-guided thermal ablation with an EM navigation system (navigation group), while the other 20 patients underwent conventional CT-guided thermal ablation (control group).

YAP1 overexpression is associated with poor prognosis of breast cancer patients and induces breast cancer cell growth by inhibiting PTEN.

YES-associated protein 1 (YAP1) plays a key role as a transcriptional coactivator in the Hippo tumor suppressor pathway. YAP1 is overexpressed in a variety of cancers and is considered to be encoded by a proto-oncogene. However, the role of YAP1 remains debatable, because both gain and loss of YAP1 expression have both been reported in breast cancer (BC).

Direct Identification of Active Surface Species for the Water-Gas Shift Reaction on a Gold-Ceria Catalyst.

The crucial role of the metal-oxide interface in the catalysts of the water-gas shift (WGS) reaction has been recognized, while the precise illustration of the intrinsic reaction at the interfacial site has scarcely been presented. Here, two kinds of gold-ceria catalysts with totally distinct gold species, <2 nm clusters and 3 to 4 nm particles, were synthesized as catalysts for the WGS reaction. We found that the gold cluster catalyst exhibited a superiority in reactivity compared to gold nanoparticles.