Development of new formulation and its evaluation by capillary electrophoresis of tablets containing tramadol hydrochloride and paracetamol.

Context: A quick and efficient method to eliminate pain is combining complementary action and substances with synergic effect. Such an association is the one between tramadol hydrochloride and paracetamol, in which the rapid reaction time of the paracetamol is combined with the long-term effect of the tramadol hydrochloride.

Objective: Our aim was to develop and characterize alternative tablet formulations containing tramadol hydrochloride 37.