Publications by authors named "Livia Marrone"
The prefrontal cortex helps adjust an organism's behavior to its environment. In particular, numerous studies have implicated the prefrontal cortex in the control of social behavior, but the neural circuits that mediate these effects remain unknown. Here we investigated behavioral adaptation to social defeat in mice and uncovered a critical contribution of neural projections from the medial prefrontal cortex to the dorsal periaqueductal gray, a brainstem area vital for defensive responses.
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- Ras-ERK signaling in the brain is crucial for understanding drug addiction, but no effective inhibitors have been tested in addiction models yet.
- Researchers developed two peptides, RB1 and RB3, that can penetrate the brain and inhibit key cellular processes related to ERK signaling.
- The study identified PD325901, a drug already in cancer clinical trials, which effectively blocks ERK signaling and reduces cocaine-related behaviors in mice, suggesting it could be useful for treating cocaine addiction.