Publications by authors named "Livia Maria Goncalves Barbosa"

Purpose: Recent vancomycin dosing and monitoring guidelines recommend monitoring vancomycin area under the 24-hour time-concentration curve instead of traditional trough-only monitoring. This study aimed to compare the total costs of vancomycin dosing and monitoring between trough-guided and AUC-guided approaches in a quaternary hospital from Brazil.

Methods: In this retrospective cohort study, patients were divided into 2 groups according to the monitoring method.

View Article and Find Full Text PDF

Objective: To assess the percentage of vancomycin area under the curve/minimum inhibitory concentration target attainment in pediatric patients after the empirical dose regimen and to demonstrate the applicability of this method for vancomycin monitoring.

Methods: A retrospective cohort study was performed including pediatric patients with normal renal function admitted between January 2020 and December 2020. The one-compartment model with first-order kinetics was used to estimate the pharmacokinetic parameters, and the area under the curve was calculated by the trapezoidal rule.

View Article and Find Full Text PDF

We analyzed trends in pharmaceutical interventions during the implementation of a new computerized physician order entry (CPOE) process in a tertiary hospital in Brazil. The new process utilized an eletronic interface that was designed in-house and an automatic order extension program. The new process reduced the number of order transcriptions and mitigated other potential CPOE-related errors [1].

View Article and Find Full Text PDF