General Characteristics, Phytochemistry and Pharmacognosy of Lippia sidoides.

Lippia sidoides Cham. is a plant that belongs to the family Verbenaceac and is commonly known as "alecrim-pimenta". It was first found in northeastern Brazil, where it is extensively used in traditional medicine.

Immunomodulatory effects and improved prognosis of experimental autoimmune encephalomyelitis after O-tetradecanoyl-genistein treatment.

Experimental autoimmune encephalomyelitis (EAE) is a murine autoimmune disease used to study multiple sclerosis (MS), a human inflammatory demyelinating disease of the central nervous system. Genistein, an isoflavonoid phytoestrogenic compound found in soy, is known to reverse clinical signs of EAE. Although genistein has some potential in clinical application, it has some disadvantages related to its chemical structure, such as rapid in vivo metabolism and a fast decline in serum after oral administration.

Synthesis of lipophilic genistein derivatives and their regulation of IL-12 and TNF-α in activated J774A.1 cells.

Genistein modulates inflammatory responses in part by reducing the production of the pro-inflammatory cytokines IL-12, TNF-α, and nitric oxide, by activated macrophages in response to lipopolysaccharide stimulus. Previous studies have shown that synthetic lipophilic genistein glycosides were significantly more active than hydrophilic glycosides. The aims of this study were to synthesize and to evaluate the effect of novel lipophilic genistein derivatives on IL-12, TNF-α, and nitric oxide production by J774A.

Preparation of amino alcohols condensed with carbohydrates: Evaluation of cytotoxicity and inhibitory effect on NO production.

This work reports the preparation of several amino alcohols condensed with d-arabinose, d-glucose, and d-galactose derivatives. These compounds were evaluated in vitro for their cytotoxicity and ability to decrease nitric oxide production in J774A.1 cells.

Synthesis and immunosuppressive activity of lipophilic amino alcohols and diamines.

In this work, we report the preparation and evaluation of the in vitro and in vivo of the immunosuppressive activity of a series of lipophilic amino alcohols and diamines. All compounds were evaluated for inhibition of cell proliferation, cytotoxicity and NO production. Compounds 9, 12, 13, 17, and 18 did not display inhibition of cell proliferation while decreased NO production.

Preparation and antitubercular activities of alkylated amino alcohols and their glycosylated derivatives.

A series of N- and C-alkylated amino alcohols and of their protected galactopyranosyl derivatives was synthesized and evaluated for antitubercular activity. Five of these compounds displayed good activity, with a MIC below 12.5mug/mL.