Publications by authors named "Livia Cunha Melo"
Randomized, phase 1/2, double-blind pioglitazone repositioning trial combined with antifungals for the treatment of cryptococcal meningitis - PIO study.
Ludmila Gouveia-Eufrasio Noelly Queiroz Ribeiro Julliana Ribeiro Alves Santos Marliete Carvalho da Costa Elúzia Castro Peres Emídio Márcia Gregory Tavares Melo Lívia Fulgêncio da Cunha Melo
Contemp Clin Trials Commun
June 2021
Article Synopsis
- - The study investigates the effectiveness and safety of pioglitazone (PIO), an antidiabetic drug, in combination with standard antifungal treatments for cryptococcosis, aiming to improve patient outcomes since current treatments have high toxicity and limited availability in Brazil.
- - Conducted as a phase 1/2 randomized, double-blind, placebo-controlled trial, patients in Belo Horizonte will be divided into three groups receiving either a placebo, PIO 15 mg/day, or PIO 45 mg/day during treatment to assess changes in mortality, fungal burden, and side effects over a follow-up period of 60 days.
- - The research aims to establish PIO as a beneficial adjuvant therapy, potentially increasing survival rates
Sydenham's chorea (SC) is the neurologic manifestation of rheumatic fever. In addition to involuntary movements, SC patients show behavioral changes, such as hyperactivity, obsessions, and compulsions. Brain-derived neurotrophic factor (BDNF) is related to neuronal development and differentiation.
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