What makes a stimulus worthy of attention: Cue-outcome correlation and choice relevance in the learned predictiveness effect.

The learned predictiveness effect refers to the tendency for predictive cues to attract greater attention and show faster learning in subsequent tasks. However, in typical designs, the predictiveness of each cue (its objective cue-outcome correlation) is confounded with the degree to which it is informative for making the correct response on each trial (a feature we term choice relevance). In four experiments, we tested the unique contributions of cue-outcome correlation and choice relevance to the learned predictiveness effect by manipulating the outcome choices available on each trial.

Prader-Willi syndrome: guidance for children and transition into adulthood.

Prader-Willi syndrome (PWS) is a rare orphan disease and complex genetic neurodevelopmental disorder, with a birth incidence of approximately 1 in 10,000-30,000. Management of people with PWS requires a multi-disciplinary approach, ideally through a multi-disciplinary team (MDT) clinic with community support. Hypotonia, poor feeding and faltering growth are characteristic features in the neonatal period, followed by hyperphagia and risk of rapid weight gain later in childhood.

Instruction on the Scientific Method Provides (Some) Protection Against Illusions of Causality.

People tend to overestimate the efficacy of an ineffective treatment when they experience the treatment and its supposed outcome co-occurring frequently. This is referred to as the effect. Here, we attempted to improve the accuracy of participants' assessments of an ineffective treatment by instructing them about the scientific practice of comparing treatment effects against a relevant base-rate, i.

The downside to choice: instrumental control increases conditioned nocebo hyperalgesia.

Nocebo hyperalgesia is a pervasive problem in which the treatment context triggers negative expectations that exacerbate pain. Thus, developing ethical strategies to mitigate nocebo hyperalgesia is crucial. Emerging research suggests that choice has the capacity to reduce nocebo side effects, but choice effects on nocebo hyperalgesia have not been explored.

Choice over placebo administration enhances open-label placebo hypoalgesia.

Many studies indicate that deceptively administered placebos can improve pain outcomes. However, the deception involved presents an ethical barrier to translation because it violates informed consent and patient autonomy. Open-label placebos (OLPs), inert treatments that are openly administered as placebos, have been proposed as an ethically acceptable alternative.

Understanding the Role of Expectancy, Anticipatory Anxiety, and Attention Bias in Nocebo Hyperalgesia: A Gaze-Contingent Attention Bias Modification Study.

Nocebo effects in pain (nocebo hyperalgesia) have been thoroughly researched, and negative expectancies have been proposed as a key factor in causing nocebo hyperalgesia. However, little is known about the psychological mechanisms by which expectations exacerbate the perception of pain. A potential mechanism that has been proposed within wider pain research is pain-related attention.

Choice Enhances Placebo Hypoalgesia More in Weaker Placebo Contexts: A Partial Reinforcement Study.

Providing individuals with choice over treatment has been found to enhance placebo hypoalgesia. However, this choice effect is not always present. The current study tested whether the strength of the placebo context influenced the effect of choice on placebo hypoalgesia.

Aversion, interpretation and determinability: Three factors of uncertainty that may play a role in psychopathology.

This opinion piece considers the construct of tolerance of uncertainty and suggests that it should be viewed in the context of three psychological factors: uncertainty aversion, uncertainty interpretation, and uncertainty determinability. Uncertainty aversion refers to a dislike of situations in which the outcomes are not deterministic and is similar to conventional conceptions of (in)tolerance of uncertainty. Uncertainty interpretation refers to the extent to which variability in an observed outcome is interpreted as random fluctuation around a relatively stable base-rate versus frequent and rapid changes in the base-rate.

Is cortical inhibition in primary motor cortex related to executive control?

Recent research using paired-pulse transcranial magnetic stimulation (TMS) has shown that the speed with which people can stop an action is linked to GABAergic inhibitory activity in the motor system. Specifically, a significant proportion of the variance in stop signal reaction time (SSRT; a widely used measure of inhibitory control) is accounted for by short-interval cortical inhibition (SICI). It is still unclear whether this relationship reflects a broader link between GABAergic processes and executive functions, or a specific link between GABAergic processes and motor stopping ability.

The effect of staircase stopping accuracy and testing environment on stop-signal reaction time.

The stop-signal task is widely used in experimental psychology and cognitive neuroscience research, as well as neuropsychological and clinical practice for assessing response inhibition. The task requires participants to make speeded responses on a majority of trials, but to inhibit responses when a stop signal appears after the imperative cue. The stop-signal delay after the onset of the imperative cue determines how difficult it is to cancel an initiated action.

Planning on Autopilot? Associative Contributions to Proactive Control.

Proactive cognitive control is thought to rely on the active maintenance of goals or contextual information in working memory. It is often measured using the AX-CPT, in which antecedent cues (A/B) are used to proactively prepare a response to a subsequently-presented probe (X/Y). Although control in this task purportedly requires active maintenance of information in working memory, it also provides conditions in which learning the contingencies between relevant events could influence performance via associative learning.

TMS reveals distinct patterns of proactive and reactive inhibition in motor system activity.

Response inhibition is our ability to suppress or cancel actions when required. Deficits in response inhibition are linked with a range of psychopathological disorders including addiction and OCD. Studies on response inhibition have largely focused on reactive inhibition-stopping an action when explicitly cued.

Choice and the Placebo Effect: A Meta-analysis.

Background: Choice has been proposed as a method of enhancing placebo effects. However, there have been no attempts to systematically evaluate the magnitude, reliability, and moderators of the influence of choice on the placebo effect.

Purpose: To estimate the effect size of choice on the placebo effect and identify any moderators of this effect.

Pseudoscientific Health Beliefs and the Perceived Frequency of Causal Relationships.

Beliefs about cause and effect, including health beliefs, are thought to be related to the frequency of the target outcome (e.g., health recovery) occurring when the putative cause is present and when it is absent (treatment administered vs.

Working memory load reduces corticospinal suppression to former go and trained no-go cues.

Environmental cues associated with an action can prime the motor system, decreasing response times and activating motor regions of the brain. However, when task goals change, the same responses to former go-associated cues are no longer required and motor priming needs to be inhibited to avoid unwanted behavioural errors. The present study tested whether the inhibition of motor system activity to presentations of former go cues is reliant on top-down, goal-directed cognitive control processes using a working memory (WM) load manipulation.

Antisocial Learning: Using Learning Window Width to Model Callous-Unemotional Traits?

Psychopathic traits and the childhood analogue, callous-unemotional traits, have been severely neglected by the research field in terms of mechanistic, falsifiable accounts. This is surprising given that some of the core symptoms of the disorder point towards problems with basic components of associative learning. In this manuscript we describe a new mechanistic account that is concordant with current cognitive theories of psychopathic traits and is also able to replicate previous empirical data.

Outcome unpredictability affects outcome-specific motivation to learn.

Outcome predictability effects in associative learning paradigms describe better learning about outcomes with a history of greater predictability in a similar but unrelated task compared with outcomes with a history of unpredictability. Inspired by the similarities between this phenomenon and the effect of uncontrollability in learned helplessness paradigms, here, we investigate whether learning about unpredictability decreases outcome-specific motivation to learn. We used a modified version of the allergy task, in which participants first observe the foods eaten by a fictitious patient, followed by allergic reactions that he subsequently suffers, some of which are perfectly predictable and others unpredictable.

Pre-Exposure, But Not Overshadowing, Inhibits Nocebo Hyperalgesia.

Nocebo hyperalgesia is a pervasive problem that significantly adds to the burden of pain. Conditioning is a key mechanism of nocebo hyperalgesia and recent evidence indicates that, once established, nocebo hyperalgesia is resistant to extinction. This means that preventive strategies are critical.

Hearing hooves, thinking zebras: A review of the inverse base-rate effect.

People often fail to use base-rate information appropriately in decision-making. This is evident in the inverse base-rate effect, a phenomenon in which people tend to predict a rare outcome for a new and ambiguous combination of cues. While the effect was first reported in 1988, it has recently seen a renewed interest from researchers concerned with learning, attention and decision-making.

Prediction-based attenuation as a general property of learning in neural circuits.

One of the mechanisms proposed to underpin perceptual learning is the reduction in salience of predicted stimuli. This reduction is held to affect the representation of (conditioned) stimuli before they have been associated with motivationally meaningful consequences but may also affect (unconditioned) stimuli that automatically elicit responding. The purpose of this article is to review past findings and present new evidence of phenomena across a range of domains that are consistent with the idea that responses automatically triggered by stimulating events will be reduced by prediction.

Does learning history shape the associability of outcomes? Further tests of the outcome predictability effect.

In recent years, several studies of human predictive learning demonstrated better learning about outcomes that have previously been experienced as consistently predictable compared to outcomes previously experienced as less predictable, namely the outcome predictability effect. As this effect may have wide-reaching implications for current theories of associative learning, the present study aimed to examine the generality of the effect with a human goal-tracking paradigm, employing three different designs to manipulate the predictability of outcomes in an initial training phase. In contrast to the previous studies, learning in a subsequent phase, when every outcome was equally predictable by novel cues, was not reliably affected by the outcomes' predictability in the first phase.

Can We Set Aside Previous Experience in a Familiar Causal Scenario?

Causal and predictive learning research often employs intuitive and familiar hypothetical scenarios to facilitate learning novel relationships. The allergist task, in which participants are asked to diagnose the allergies of a fictitious patient, is one example of this. In such studies, it is common practice to ask participants to ignore their existing knowledge of the scenario and make judgments based only on the relationships presented within the experiment.

Attention biases in the inverse base-rate effect persist into new learning.

The inverse base-rate effect is a tendency to predict the rarer of two outcomes when presented with cues that make conflicting predictions. Attention-based accounts of the effect appeal to prioritised attention to predictors of rare outcomes. Changes in the processing of these cues are predicted to increase the rate at which they are learned about in the future (i.

Expected TMS excites the motor system less effectively than unexpected stimulation.

The brain's response to sensory input is modulated by prediction. For example, sounds that are produced by one's own actions, or those that are strongly predicted by environmental cues, elicit an attenuated N1 component in the auditory evoked potential. It has been suggested that this form of sensory attenuation to stimulation produced by one's own actions is the reason we are unable to tickle ourselves.