Publications by authors named "Livan Delgado"
Rheumatoid Arthritis (RA) is the most prevalent chronic condition present in ~1% of the adult population. Many pro-inflammatory mediators are increased in RA, including Reactive Oxygen Species such as nitric oxide NO, pro-inflammatory cytokines as tumor necrosis factor alpha (TNF-α), interleukin-1beta (IL-1β) and other molecules. Ozone oxidative postconditioning has regulatory effects on some pathological targets associated with RA.
View Article and Find Full Text PDFAntiatherosclerotic effect of an antibody that binds to extracellular matrix glycosaminoglycans.
Arterioscler Thromb Vasc Biol
March 2012
Article Synopsis
- The study investigates a chimeric monoclonal antibody (chP3R99) that targets sulfated molecules, showing potential in preventing atherosclerosis by blocking the retention and oxidation of low-density lipoproteins (LDL) in blood vessels.
- ChP3R99 significantly inhibited LDL retention and oxidation in laboratory settings and demonstrated a 22-fold reduction in atherosclerosis risk when administered to rabbits.
- The findings suggest that immunotherapy using anti-sulfated glycosaminoglycan antibodies can be an effective strategy for preventing atherosclerosis, as it leads to a reduced macrophage infiltration and preserved vascular health.