Effect modification in network meta-analyses for relapsed/refractory multiple myeloma: systematic review and meta-analysis.

Objectives: To systematically review and meta-analyse the evidence for effect modification by refractory status and number of treatment lines in relapsed/refractory multiple myeloma (RRMM); and to assess whether effect modification is likely to invalidate network meta-analyses (NMA) that assume negligible modification.

Design: Systematic review, meta-analysis and simulation.

Data Sources: We systematically searched the literature (e.

Comparison of daily and weekly retrospectively reported pain intensity in patients with localized and generalized musculoskeletal pain.

The purpose of the study was to compare daily and weekly recalled pain intensity over time and their correspondence with real-time pain intensity in patients with localized (LP) and generalized (GP) musculoskeletal pain. Daily recalled pain, averaged over seven consecutive days, and weekly recalled pain at day 8 were recorded on 100 mm visual analogue scales monthly over 4 months for 40 LP and 50 GP patients. Multiple real-time pain ratings on numerical rating scales (0-10) were averaged over the week for 23 LP and 33 GP patients in Month 4.

Attenuated adrenergic responses to exercise in women with fibromyalgia--a controlled study.

The pathogenesis of widespread pain and fibromyalgia (FM) is unknown. Altered responses from the hypothalamus-pituitary-adrenal axis, sympathetic nervous system and muscular system have been suggested as being of importance. The present study was undertaken to determine: (i) whether the sympathoadrenal response to repetitive isometric contractions until exhaustion is altered in patients with FM, and (ii) whether sympathoadrenal responses are associated with muscle fatigue and pain during exercise.

Pulmonary function, working capacity and strength in young adults with Marfan syndrome.

Objective: To investigate pulmonary function, working capacity and isokinetic muscle strength in subjects with Marfan syndrome.

Materials And Methods: Seventeen subjects, mean age 23 years, performed spirometry, maximal ergometer cycle tests and knee extension and flexion isokinetic torque tests.

Results: The subjects with Marfan syndrome had increased total and residual lung volume values compared with predicted values in healthy subjects and reduced peak oxygen uptake compared with healthy subjects of the same age.