Publications by authors named "Liuzzo G"
Purpose Of The Review: This review discusses the molecular mechanisms involved in the immuno-pathogenesis of atherosclerosis, the pleiotropic anti-inflammatory effects of approved cardiovascular therapies and the available evidence on immunomodulatory therapies for atherosclerotic cardiovascular disease (ACVD). We highlight the importance of clinical and translational research in identifying molecular mechanisms and discovering new therapeutic targets.
Recent Findings: The CANTOS (Canakinumab Anti-Inflammatory Thrombosis Outcomes Study) trial was the first to demonstrate a reduction in cardiovascular (CV) risk with anti-inflammatory therapy, irrespective of serum lipid levels.
Cardiogenic shock (CS) is a life-threatening condition. The aim of this study is to evaluate the clinical characteristics, management, and complication rate of patients with CS admitted to a high-volume hospital in Italy. We retrospectively reviewed the clinical, echocardiographic, and laboratory data, therapeutic management, and outcomes of patients with CS admitted to the Policlinico Gemelli (Rome) between January 1, 2020, and January 1, 2023.
View Article and Find Full Text PDFBackground: Cardiovascular diseases (CVDs) pose a significant global health challenge, necessitating innovative approaches for primary prevention. Personalized prevention, based on genetic risk scores (PRS) and digital technologies, holds promise in revolutionizing CVD preventive strategies. However, the clinical efficacy of these interventions requires further investigation.
View Article and Find Full Text PDFThe internet and digital technologies pose new, specific challenges to competent authorities, whose activity fields are limited to their own jurisdictions. Consequently, these authorities must operate a system of controls adapted to online sites and e-sales, and official control must be strengthened. To address these challenges and protect consumers from misleading practices that can lead to the consumption of unsafe food, it is necessary to adapt official controls to new distance-selling techniques.
View Article and Find Full Text PDFArticle Synopsis
- The CARdio-Tox study investigated the cardiovascular complications associated with Chimeric Antigen Receptor-T (CAR-T) cell therapy, particularly focusing on the incidence of cancer therapy-related cardiac dysfunction (CTRCD) amidst cytokine release syndrome (CRS).* -
- Patients with blood malignancies underwent echocardiography before and at 7 and 30 days post-CAR-T infusion, revealing a high CTRCD incidence of 59.3% at 7 days, especially in those experiencing CRS.* -
- The study found significant correlations between early declines in heart function metrics and inflammatory markers, emphasizing the need for ongoing patient monitoring to address potential cardiac issues related to CAR-T therapy.*
Article Synopsis
- The study looked at how to identify problems in patients with certain heart issues using a test called acetylcholine (ACh) provocation testing.
- Researchers created a score called the ABCD score to help predict if patients would have a positive test result based on specific factors.
- The ABCD score could help reduce unnecessary testing for patients with high scores, making treatments safer and more efficient, but more research is needed to confirm its effectiveness.
Vaccines and myocardial injury in patients hospitalized for COVID-19 infection: the CardioCOVID-Gemelli study.
Eur Heart J Qual Care Clin Outcomes
January 2025
Article Synopsis
- Myocardial injury is common in COVID-19 patients, but the impact of COVID-19 vaccines on this risk is not well understood.
- A study involving 1019 hospitalized COVID-19 patients found that older age, chronic kidney disease, and hypertension were linked to myocardial injury, while vaccination status did not significantly impact risk.
- In patients aged 76 and older, vaccines appeared to protect against myocardial injury, but in those aged 60 and younger, vaccination was associated with an increased risk of injury.