Publications by authors named "Liuyi Shen"
Article Synopsis
- TSTA3 gene, linked to tumor prognosis, shows increased expression in lung cancer, particularly in lung squamous cell carcinoma (LUSC), suggesting its potential as a prognostic factor.
- High TSTA3 levels correlate with malignant traits in LUSC, supported by COX regression analysis and immunohistochemistry findings.
- Functional studies indicate that TSTA3 enhances LUSC cell proliferation, invasion, and migration, while its knockdown decreases these properties; transcriptome analysis suggests its role in the lysosome pathway is crucial for these effects.
Importance: The onset age of nonalcoholic fatty liver disease (NAFLD) is decreasing, and whether earlier ages of NAFLD onset are associated with increased cancer risk is currently unclear.
Objective: To explore the association between NAFLD new-onset age and cancer risk.
Design, Setting, And Participants: This cohort study was conducted among 179 328 participants included in the Kailuan Cohort Study between 2006 and 2021.
Article Synopsis
- The study investigates how muscle distribution affects both overall and specific mortality rates, aiming to clarify the relationship between muscle mass and health outcomes over time.
- It analyzes data from 5,052 participants aged around 45 years and includes additional validation with 3,040 patients from China, using regression methods to evaluate the impact of muscle in different body areas.
- Results show that greater muscle mass in upper and lower limbs, as well as the trunk, is linked to better survival rates, with age and sex influencing this relationship, particularly noting a stronger effect in men and middle-aged individuals.
Background: Cachexia is one of the most common complications affecting lung cancer patients that seriously affects their quality-of-life and survival time. This study aimed to analyze the predictors and prognostic factors of lung cancer cachexia as well as to develop a convenient and accurate clinical prediction tool for oncologists.
Methods: In this multicenter cohort study, 4022 patients with lung cancer were retrospectively analyzed.
Background: Aberrant glycosylation has been recognized as a hallmark of cancer and N-glycosylation is one of the main types of glycosylation in eukaryotes. Although N-glycoproteomics has made contributions to the discovery of biomarkers in a variety of cancers, less is known about the abnormal glycosylation signatures in esophageal squamous cell carcinoma (ESCC).
Methods: In this study, we reported the proteomics and N-glycoproteomic site-mapping analysis of eight pairs of ESCC tissues and adjacent normal tissues.