Publications by authors named "Liuxin Zhou"
Article Synopsis
- The research aimed to create an algorithm that predicts acute respiratory failure (ARF) in patients suffering from acute pancreatitis (AP) using data from the Medical Information Mart for Intensive Care IV database.
- Data was divided into training and validation groups, and various machine learning models such as logistic regression and XGBoost were developed to assess ARF risk based on specific clinical features like calcium and albumin levels.
- The XGBoost model showed promising results, with a high accuracy rate of around 86%, effectively helping clinicians estimate the likelihood of ARF in AP patients.
Article Synopsis
- Liver transplantation rejection is a significant issue, and the role of myeloid-derived suppressor cells (MDSCs) in this process is not well understood.
- This study investigated MDSCs by analyzing liver tissues and blood samples from patients and mouse models during varying degrees of rejection, finding a correlation between high rejection levels and increased M-MDSC and PD-1+ T-cell presence.
- Results revealed that CD84 plays a critical role in regulating M-MDSC functions, promoting T-cell exhaustion and possibly contributing to liver transplant rejection dynamics.
FLT3 DC inhibits immune rejection via interaction with Treg in liver transplantation.
Int Immunopharmacol
August 2024
Fms-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase (RTK) primarily expressed in hematopoietic stem cells and dendritic cells (DCs). While FLT3 plays a critical role in the proliferation, development and maintenance of DCs, thus influencing immune responses under both normal and pathological conditions, there also exists some evidence that FLT3DC may be involved with immune responses in liver transplantation (LT). In this study, results from single-cell sequencing data analysis revealed a clear relationship between FLT3DCs and Regulatory T cells (Tregs) in liver tissue of LT recipients.
View Article and Find Full Text PDFObjective: This study aimed to investigate the clinical characteristics and risk factors of patients with hepatocellular carcinoma (HCC) with extrahepatic metastases (EHM) and to establish an effective predictive nomogram.
Methods: Clinical and pathological data from 607 patients with hepatocellular carcinoma admitted to the Affiliated Hospital of Qinghai University between 1 January 2015 and 31 May 2018 were documented, as well as demographics, clinical pathological characteristics, and tumor-related parameters to clarify clinical risk factors for HCC EHM. These risks were selected to build an R-based clinical prediction model.
Article Synopsis
- Liver transplantation (LT) is a successful treatment for end-stage liver disease, but immune rejection poses a major challenge to patient survival and prognosis.
- The study utilized a protein chip system and proteomics to analyze serum proinflammatory cytokines and liver tissue proteins in a mouse model, revealing significant changes in cytokine levels post-transplant.
- Key findings included increased levels of GC-CSF, CXCL-1, MCP-5, and CXCL-2, along with the identification of enriched pathways related to immune responses and specific proteins associated with transplant rejection, suggesting new targets for treatment.
Hepatic ischemia-reperfusion injury (IRI) is an adverse consequence of hepatectomy or liver transplantation. Recently, immune mechanisms involved in hepatic IRI have attracted increased attention of investigators working in this area. In specific, group 2 innate lymphoid cells (ILC2s), have been strongly implicated in mediating type 2 inflammation.
View Article and Find Full Text PDFCharacteristics of changes in double positive CD4CD8 T cells in liver transplantation.
Int Immunopharmacol
September 2022
Although double positive CD4CD8 T (DPT) cells has been reported to be involved in some diseases, their trajectory and function as associated with liver transplantation (LT) remain unclear. In the present study, we found that the number of DPT cells was increased in the blood and liver tissue of LT patients. Meanwhile, we compared the distribution of DPT cells in peripheral blood samples and in penetrating liver tissue between liver rejection versus non-rejection patients, as well as the proportion of DPT cells as a function of the extent of liver rejection.
View Article and Find Full Text PDFMiR-34a targets SNAI1 and is essential for 5-hydroxytryptamine induced epithelial mesenchymal transition in liver cancer.
Minerva Gastroenterol (Torino)
September 2022