Modeling diabetes progression with risk factors: A case study in China.

Background: Approximately 537 million adults worldwide have diabetes, more than 90 % of which is type 2 diabetes mellitus (T2DM). China has the largest number of people living with diabetes. Understanding the epidemiological mechanism can guide diabetes surveillance and control.

NUSAP1 is Upregulated by Estrogen to Promote Lung Adenocarcinoma Growth and Serves as a Therapeutic Target.

Nucleolar and spindle-associated protein 1 (NUSAP1), a microtubule-associated protein, has been recently identified to exhibit aberrant expression patterns that correlate with malignant tumorigenesis and progression across various cancer types. However, the specific regulatory mechanisms and potential targeting therapies of NUSAP1 in lung adenocarcinoma (LUAD) remain largely elusive. In this study, by conducting bioinformatics analyses as well as and experiments, we identified that NUSAP1 was significantly upregulated in LUAD, with a notable correlation with poorer overall survival, higher scores for immunogenicity and immune infiltration, as well as increased sensitivity to conventional chemotherapeutic drugs such as paclitaxel, docetaxel and vinorelbine in LUAD.

Probe-Type Multi-Core Fiber Optic Sensor for Simultaneous Measurement of Seawater Salinity, Pressure, and Temperature.

In this article, we propose and demonstrate a probe-type multi-core fiber (MCF) sensor for the multi-parameter measurement of seawater. The sensor comprises an MCF and two capillary optical fibers (COFs) with distinct inner diameters, in which a 45° symmetric core reflection (SCR) structure and a step-like inner diameter capillary (SIDC) structure filled with polydimethylsiloxane (PDMS) are fabricated at the fiber end. The sensor is equipped with three channels for different measurements.

Identification and Validation of a Novel Six-Gene Expression Signature for Predicting Hepatocellular Carcinoma Prognosis.

Background: Hepatocellular carcinoma (HCC) is a highly lethal disease. Effective prognostic tools to guide clinical decision-making for HCC patients are lacking.

Objective: We aimed to establish a robust prognostic model based on differentially expressed genes (DEGs) in HCC.

Resolution-improved SPR sensor with a rotational modulation method.

A resolution-improved prism coupler-based surface plasmon resonance (SPR) sensor with a simple, effective rotational modulation method is proposed in this paper. For a conventional SPR sensor, the way to improve its measurement resolution is usually to use the rotating device with higher resolution. Measurement resolution depends on the modulation resolution of the incident angle; therefore, we propose a rotational modulation method that is implemented by rotating the prism horizontally to improve the modulation resolution of the incident angle, instead of using a more expensive rotating device with higher resolution.

The Expression Level of and Its Changes during Chemotherapy in Patients with Different Pathological Types of Mammary Cancer.

Background: We aimed to investigate the expression level of breast cancer susceptibility gene 2 () and its changes during chemotherapy in patients with different pathological types of mammary cancer (MC).

Methods: Overall, 102 patients treated in Affiliated Tumor Hospital of Guangxi Medical University, China from April 2013 to August 2017 were enrolled as experimental group, including 58 patients with noninvasive MC (group A) and 44 with invasive MC (group B). Fifty healthy volunteers at the same time were enrolled as control group.

Evaluation of the value of GATA3 combined with E-cadherin in the diagnosis of breast cancer.

Purpose: To analyze the clinical value of GATA-3 combined with E-cadherin in the diagnosis of breast cancer.

Methods: 120 patients with breast cancer treated in Affiliated Tumor Hospital of Guangxi Medical University for the first time (experimental group) from May 2014 to December 2016 and 80 healthy females (control group) were retrospectively analyzed. The expression levels of GATA3 and E-cadherin in the experimental group and the control group were detected by enzyme-linked immunosorbent assay (ELISA).