Isolation and Characterization of Antimicrobial Metabolites from the -Associated Fungus sp. GDGJ-N37.

Chemical investigation of sp. GDGJ-N37, a -associated fungus, yielded two new azaphilone derivatives, N-isoamylsclerotiorinamine () and 7-methoxyl--isoamylsclerotiorinamine (), and four known azaphilones (-), together with two new chromone derivatives, penithochromones X and Y ( and ). Their structures were elucidated based on spectroscopic data, CD spectrum, and semi-synthesis.

Two new cytochalasins from the endophytic fungus sp. GDGJ-77B.

Two new open-chain cytochalasins, xylarchalasins A and B ( and ), together with six known analogues (-), were isolated from the endophytic fungus sp. GDGJ-77B from the Chinese medicinal plant . Their structures were elucidated on the basis of comprehensive spectroscopic analysis.

Cycloaspeptide H, a cyclopentapeptide from the endophytic fungus .

One new cyclopentapeptide, cycloaspeptide H (), featuring a serine residue, along with seven known compounds (-), was isolated from the endophytic fungus GDGJ-227. The planar structure of was elucidated by a comprehensive analysis of NMR and MS spectroscopic spectra, and the absolute configuration was determined by single-crystal X-ray diffraction (Cu Kα) analysis. Compounds and displayed antibacterial activities against and with MIC values ranging from 12.