Well-defined star (co)polypeptides via a fast, efficient, and metal-free strategy.

Polypeptides, especially star polypeptides, as a unique kind of biological macromolecules have broad applications in biomedical fields such as drug release, gene delivery, tissue engineering, and regenerative medicines due to their close structural similarity to naturally occurring peptides and proteins, biocompatibility, and amino acid functionality. However, the synthesis of star polypeptide mainly relies on the conventional primary amine-initiated ring-opening polymerization (ROP) of N-carboxyanhydrides (NCA) and suffers from low polymerization activity and limited controllability. This study proposes a fast, efficient and metal-free strategy to access star (co)polypeptides by combining the Michael reaction between acrylates and secondary aminoalcohols with the hydrogen-bonding organocatalytic ROP of NCA.

Environmentally friendly strategy to access self-healable, reprocessable and recyclable chitin, chitosan, and sodium alginate based polysaccharide-vitrimer hybrid materials.

Natural polysaccharides show enviable advantages for preparation of sustainable hybrid materials. However, in most cases, complex chemical modifications of natural polysaccharides are required, which not only causes changes of the inherent properties of polysaccharides, but also increases the manufacturing costs of the final materials. Therefore, it is highly desired to develop efficient and low-cost ways to access polysaccharides-containing hybrid materials.