[Comparison of B-NDG and BALB/c mouse models bearing patient-derived xenografts of esophageal squamous cell carcinoma].

Objective: To investigate the difference of tumor formation in different mouse strains bearing patient-derived xenograft of esophageal squamous cell carcinoma(ESCC) and establish a better animal model for preclinical study of individualized treatment of ESCC.

Methods: The tumor tissues collected from 22 ESCC patients were used to establish tumor-bearing mouse models in B-NDG (NSG) mice and BALB/c nude mice. The tumor formation rate and tumor formation time were compared between the two mouse models, and HE staining, immunohistochemistry and genome sequencing were carried out to assess the consistency between transplanted tumor tissues in the models and patient-derived tumor tissues.

HSP90 Inhibitor Ganetespib (STA-9090) Inhibits Tumor Growth in c-Myc-Dependent Esophageal Squamous Cell Carcinoma.

Purpose: Currently, the paucity of classical effective pharmacological drugs to treat esophageal squamous cell carcinoma (ESCC) is a major problem. The c-Myc (MYC) protein is a promising target as it is overexpressed in ESCC. MYC is a sensitive client protein of the heat shock protein 90 (HSP90) and, therefore, targeting the HSP90-MYC axis by inhibition of HSP90 is a potential therapeutic strategy for ESCC.

Evolution of Zeolite Crystals in Self-Supporting Faujasite Blocks: Effects of Hydrothermal Conditions.

In order to prepare self-supporting faujasite (FAU) zeolite, a self-supporting zeolite block was synthesized in situ by hydrothermal treatment of a metakaolin base geopolymer. The effects of hydrothermal conditions such as hydrothermal alkalinity, temperature and time on the phase composition, microstructure and mechanical strength of the hydrothermal samples were investigated and evidenced by a series of characterization methods such as X-ray diffraction (XRD), scanning electron microscopy (SEM), and Brunauer-Emmet-Teller (BET). The results showed that a self-supporting faujasite block could be obtained by hydrothermal treatment of the geopolymer block in 2 M NaOH solution at 90 °C for 24 h, which had high crystallinity, regular morphology and high compressive strength.