Publications by authors named "Liujin Hou"
A member of the short-chain dehydrogenase/reductase superfamily (DHRS1, SDR19C1) is a member of the short-chain dehydrogenase/reductase superfamily and a potential predictor of hepatocellular carcinoma (HCC). However, the role of DHRS1 in HCC immunity remains unclear. We systematically analyzed the association between DHRS1 and HCC immunity with transcriptional and clinical data from the Tumor Immune Estimation Resource, an integrated repository portal for tumor immune system interactions, and cBioPortal databases.
View Article and Find Full Text PDFLet-7c-5p down-regulates immune-related CDCA8 to inhibit hepatocellular carcinoma.
Funct Integr Genomics
February 2023
Objective: The aim of this study is to investigate the effect of let-7c-5p on the malignant behaviors of hepatocellular carcinoma (HCC) and its specific molecular pathway.
Methods: Differential expression and survival analysis of let-7c-5p were obtained from The Cancer Genome Atlas database, and then its expression level was preliminarily verified through qPCR. The effect of let-7c-5p on the malignant phenotype of HCC cells was subsequently evaluated using CCK-8, transwell, wound healing, and flow cytometry assays.
Article Synopsis
- High serum CA19-9 levels are typically linked to pancreaticobiliary cancers, but can also appear in a small number of patients with calculous cholecystitis.
- The study analyzed data from 20 patients with high serum CA19-9 and 40 with normal levels who underwent gallbladder surgery, revealing significant changes in CA19-9 levels post-surgery.
- The findings indicate that elevated CA19-9 can be associated with calculous cholecystitis, suggesting that doctors should consider this condition when interpreting CA19-9 results.
Colon cancer is the fifth most common cause of cancer-related death worldwide, and despite significant advances in related treatment, the prognosis of colon cancer patients remains poor. This study performs systematic bioinformatics analysis of prognostic-associated RNA processing factor genes in colon cancer using the Cancer Related Genome Atlas database to explore their role in colon carcinogenesis and prognosis and excavate potential therapeutic targets. Data sets of colon cancer patients were obtained from GEO and TCGA databases.
View Article and Find Full Text PDFBackground: Acute-on-chronic liver failure (ACLF) patients have high mortality in a short period of time. This study aimed to compare the prognosis of transplanted ACLF patients to that of nontransplanted ACLF patients and decompensated cirrhosis recipients.
Methods: Clinical data of 29 transplanted ACLF patients, 312 nontransplanted ACLF patients, and 60 transplanted decompensated cirrhosis patients were retrospectively collected.
The long noncoding RNA growth-arrest specific 5 (GAS5) is a suppressor of many cancers. However, the role and mechanism of action of GAS5 in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remain unclear. Here, the expression of hepatitis B virus x gene (HBx) mRNA and GAS5 was assessed by qRT-PCR, and western blot analysis was performed to determine the protein expression levels.
View Article and Find Full Text PDFArticle Synopsis
- Immune checkpoint inhibitors, like toripalimab, are becoming popular in treating solid tumors, including liver cancer (HCC).
- The safety of these inhibitors before or after liver transplant is still unclear, with previous reports mainly focusing on posttransplant rejection issues.
- In a case study, a patient who received toripalimab before liver transplant experienced severe acute hepatic necrosis, suggesting a potential link to immune rejection triggered by the treatment.