Publications by authors named "Liudmyla Y Zurnadzhy"
Deletion of the long q arm of chromosome 22 (22qDEL) is the most frequently identified recurrent somatic copy number alteration (SCNA) observed in papillary thyroid carcinoma (PTC). Since its role in PTC is not fully understood, we conducted a pooled analysis of genomic characteristics and clinical correlates in 1094 primary tumors from four published PTC genomic studies. The majority of PTC with 22qDEL exhibited arm-level loss of heterozygosity (86%); nearly all PTC with 22qDEL had losses in 22q12 and 13, which together constitute 70% of the q arm.
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- Childhood exposure to radioactive iodine from the Chornobyl accident increases the risk of papillary thyroid carcinoma (PTC), particularly in younger individuals.
- A study of 428 PTC cases found that cervical lymph node metastases (cLNM) were more common in PTC with certain genetic fusions compared to mutations, and this frequency varied significantly by specific gene types.
- Molecular profiling of the cLNM showed strong genetic concordance with primary PTCs and identified 17 differentially expressed genes, pointing to potential biological mechanisms in PTC metastasis that require further investigation.
The 1986 Chernobyl nuclear power plant accident increased papillary thyroid carcinoma (PTC) incidence in surrounding regions, particularly for radioactive iodine (I)-exposed children. We analyzed genomic, transcriptomic, and epigenomic characteristics of 440 PTCs from Ukraine (from 359 individuals with estimated childhood I exposure and 81 unexposed children born after 1986). PTCs displayed radiation dose-dependent enrichment of fusion drivers, nearly all in the mitogen-activated protein kinase pathway, and increases in small deletions and simple/balanced structural variants that were clonal and bore hallmarks of nonhomologous end-joining repair.
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- * This study compared the tumor characteristics of PTCs from Chernobyl-exposed patients in Ukraine to those in Fukushima and other Japanese regions, including various age groups in the analysis.
- * Ukrainian radiogenic PTCs showed greater invasiveness and distinct morphological features compared to sporadic cases, particularly in children, while no significant differences were found between the Japanese PTC groups, aside from a higher male proportion in the cohort.
Background: The issue of whether radiation-induced thyroid cancer is pathologically different from sporadic remains not fully answered. This study compared structural characteristics and invasive features of papillary thyroid carcinoma (PTC) in two age-matched groups: patients who were children (≤4 years old) at the time of the Chernobyl accident and who lived in three regions of Ukraine most contaminated by radioactive iodine I ("radiogenic" cancer), and those who lived in the same regions but who were born after 1987 and were not exposed to I ("sporadic" cancer). Further, the histopathologic features of PTC were analyzed in relation to age and individual I thyroid dose.
View Article and Find Full Text PDFThis study set out to compare structural and invasive characteristics of sporadic papillary thyroid carcinoma (PTC) in age-matched groups of children and adolescents of Japan and Ukraine to provide detailed histopathological analysis of tumors from different geographical areas with different iodine intake. A total of 348 (160 Japanese and 188 Ukrainian) PTCs from patients without radiation history were analyzed initially as a combined pediatric group and then subdivided into childhood (aged ≤14 years) and adolescent (aged from 15 to ≤18 years) age series. On multivariate comparison, the Japanese pediatric PTC was characterized by a higher sex ratio (p=1.
View Article and Find Full Text PDFBackground: There are limited data on the histopathology of papillary thyroid carcinomas (PTCs) diagnosed in irradiated populations. We evaluated the associations between iodine-131 dose and the histopathological characteristics of post-Chernobyl PTCs, the changes in these characteristics over time, and their associations with selected somatic mutations.
Methods: This study included 115 PTCs diagnosed in a Ukrainian-American cohort (n=13,243) during prescreening and four successive thyroid screenings.