Publications by authors named "Liudmyla Fira"
Article Synopsis
- The study investigated how exposure to malathion and carbon tetrachloride affects bioenergetic processes in rats and whether the enterosorbent enterosgel helps mitigate these effects.
- Rats were divided into nine groups, receiving malathion daily and carbon tetrachloride twice, while measuring enzyme activity related to energy metabolism and glucose levels.
- Results showed that enterosgel improved mitochondrial enzyme activity and reduced serum glucose, indicating a restoration of energy processes in the rats following toxic exposure.
Objective: The aim: To study pro- and antioxidant systems indicators in rats with chemically induced colon carcinogenesis on the background of the reishi mushrooms dry extract use.
Patients And Methods: Materials and methods: The study was performed on 120 white male rats. Chronic oncogenic intoxication was modeled by administering 1,2-dimethyl¬hydrazine (DMH) hydrochloride for 30 weeks (1 time per week).
Glutathione (GSH) has been the focus of increased scientific interest in the last decades. It plays a crucial role in all major physiological processes by supplying antioxidant defenses through participating in cellular redox reactions in the human body and other living organisms. GSH also participates in detoxifying xenobiotics, protecting protein thiols from crosslinking and oxidation, regulating the cell cycle, storing cysteine, etc.
View Article and Find Full Text PDFBackground: Every year the number of cases of colorectal cancer increases. Chemotherapy is one of the main methods of treating cancer. However, chemotherapeutic treatment of colorectal cancer is inextricably linked to hepatotoxic reactions.
View Article and Find Full Text PDFUnlabelled: It is known that the violation of one or more functions of the liver, where the basic biochemical processes take place, is reflected in the functional state of many organs and systems, causing severe consequences. For the effective treatment of the hepatobiliary system diseases the drugs from fungi and plant materials are promising, the ingredients of which are close to natural metabolites, have different mechanisms of hepatoprotective action and, in general, can have a positive effect on liver function.
Aim: The aim of the research was to investigate the hepatoprotective properties of the Maitake mushrooms thick extract in the experiment on rats with paracetamol (acetaminophen)-induced hepatitis.
Unlabelled: The number of cancer patients is growing in all countries. Due to the malignant progression of cancer, inflammatory processes are observed, which are inextricably linked with the response of the immune system.
Aim: The aim of this research was to study the effectiveness of the cytostatic Vincristine on the background of sorption correction of disorders by the carbon sorbent AUT-M (activated carbon tissue material) in adenocarcinoma of the colon.