Publications by authors named "Liudmila Kh Pastushkova"
Background/objectives: The development of blood tests for the early detection of individual predisposition to socially significant diseases remains a pressing issue.
Methods: In this pilot study, multiple reaction monitoring mass spectrometry (MRM-MS) with a BAK-270 assay was applied for protein concentrations analysis in blood plasma from 21 healthy volunteers of the European cohort.
Results: The levels of 138 plasma proteins were reliably and precisely quantified in no less than 50% of samples.
Article Synopsis
- Space flight significantly impacts the human body's physiological processes, but the underlying molecular mechanisms are not fully understood.
- Blood samples from 18 Russian cosmonauts during a long-duration mission were analyzed for changes in protein levels before and after their return to Earth using advanced mass spectrometry techniques.
- The study found that space flight leads to a reduction in plasma volume and increases levels of certain proteins associated with inflammation and muscle recovery, with notable changes continuing for up to seven days post-landing.