Current Role of Modern Chromatography with Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy in the Investigation of Biomarkers of Endometriosis.

Endometriosis has a wide range of clinical manifestations, and the disease course is unpredictable, making the diagnosis a challenging task. Despite significant advances in the pathophysiology of endometriosis and various proposed theories, the exact etiology is not fully understood and is still unknown. The most commonly used biomarker of endometriosis is CA-125, however, it is nonspecific and is applied for cancers diagnosis.

Development of a capillary electrophoretic method for determination of ketorolac enantiomers in human plasma using cationic β-cyclodextrin derivative as a chiral selector.

A novel approach for the separation of ketorolac enantiomers by capillary electrophoresis is presented. A cationic β-cyclodextrin derivative based on imidazole was synthesized and used as a chiral selector in the background electrolyte. The influence of pH and ionic strength of background electrolyte, as well as cationic β-cyclodextrin derivative concentration on the resolution of ketorolac enantiomers, was investigated.

Development of approach for flavonoid profiling of biotechnological raw materials Iris sibirica L. by HPLC with high-resolution tandem mass spectrometry.

Introduction: Iris L. are promising in medicine due to the biological activity of extracts. Iris sibirica L.

Classification of ballpoint pen inks based on selective extraction and subsequent digital color and cluster analyses.

Here, we propose a novel approach to the classification of blue ballpoint pen inks based on a combination of selective extraction of coloring components from a paper carrier, digital color analysis (DCA) of the remaining traces, and hierarchical cluster analysis of DCA results. Since most documents of high importance are still produced in hard copies, the proposed method, being highly time- and cost-efficient, could be a significant contribution to forensic science in the field of authenticating handwritten documents. Several commonly used solvents were applied in parallel as extractants to the replicate strokes produced by each pen.