Publications by authors named "Liubing Xia"
Background: Diagnosis of kidney transplant rejection currently relies on manual histopathological assessment, which is subjective and susceptible to inter-observer variability, leading to limited reproducibility. We aim to develop a deep learning system for automated assessment of whole-slide images (WSIs) from kidney allograft biopsies to enable detection and subtyping of rejection and to predict the prognosis of rejection.
Method: We collected H&E-stained WSIs of kidney allograft biopsies at 400x magnification from January 2015 to September 2023 at two hospitals.
Article Synopsis
- Rejection significantly impacts the long-term success of kidney transplants, making early detection and treatment crucial for improving outcomes.
- The study investigates the role of RNA-binding proteins (RBPs) in kidney transplant rejection by analyzing gene expression data and identifying eight key RBPs that are upregulated during rejection.
- A new prediction model developed from these RBPs shows high diagnostic accuracy for T cell mediated rejection and can effectively forecast graft survival in both rejection and non-rejection cases.
Transplant renal vein thrombosis is a rare complication after kidney transplantation, which can seriously threaten graft survival. Though the measures like thrombolytic therapy or operative intervention could be taken to deal with this complication, allograft loss is the most common outcome. Thus, early finding as well as decisive intervention is crucial to saving the graft.
View Article and Find Full Text PDFBackground: Antisperm antibodies (ASA) in males cause the autoimmune disease 'immune infertility'. The mechanism of ASA cause male infertility is not clear. Present studies have investigated the effect of ASA and their incidence in men with unexplained infertility, as well as to evaluate the correlation between the ASA and semen parameter alterations but have shown inconsistent results.
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