Publications by Liu-Zhen Xiao

Publications by authors named "Liu-Zhen Xiao"

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[Significance and mechanisms of overexpression of PAK1 gene in epithelial ovarian neoplasms].

Dan Xie Guo-Feng Yang Yu-Qing Chen Lin-Fang Jiang Liu-Zhen Xiao

Zhonghua Zhong Liu Za Zhi

December 2006

Objective: To investigate the significance and mechanisms of overexpression of p21-activated kinase 1 gene (PAK1) in epithelial ovarian neoplasms.

Methods: Immunohistochemistry, fluorescence in situ hybridization and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling methods were used to examine the protein expression and amplification of PAK1 and cell apoptosis in 30 benign ovarian adenomas, 20 borderline tumors and 80 ovarian carcinomas by tissue microarray.

Results: In immunohistochemistry study, overexpression of PAK1 protein was observed in 7 (25.

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- Liu-Zhen Xiao's research primarily focuses on the overexpression of the PAK1 gene in epithelial ovarian neoplasms, aiming to understand its significance and underlying mechanisms.
- The studies incorporate various techniques such as immunohistochemistry, fluorescence in situ hybridization, and TUNEL assay to analyze the expression and amplification of the PAK1 gene across different ovarian tumor types.
- Findings revealed that PAK1 overexpression is significantly associated with ovarian carcinomas, highlighting its potential role in cancer progression and suggesting it as a possible target for therapeutic intervention.

Publications by authors named "Liu-Zhen Xiao"

[Significance and mechanisms of overexpression of PAK1 gene in epithelial ovarian neoplasms].

Synopsis of recent research by authors named "Liu-Zhen Xiao"