The structure modification with glucosamine of glycyrrhetinic acid extracted from Glycyrrhiza uralensis Fisch offal and mechanism of action based on network pharmacology and molecular docking against type II diabetes.

In order to improve the solubility and hypoglycemic activity of glycyrrhetinic acid (GA), the active mechanism of action of new compounds was explored. A novel 2-(N-3-acetylglycyrrhetinoyl)-N-glucopyranosyl-2-acetamide (compound 9) was synthesized by adding glucosamine (GlcN) to the C-30 carboxyl group of GA, and the hypoglycemic activity mechanism of compound 9 was explored by network pharmacology and molecular docking. The results showed that the solubility of compound 9 was better than GA, and the α-glucosidase inhibitory effect of compound 9 (IC50 = 0.

Rheological properties of polysaccharides from Pholiota nameko with different temperature extraction: Concentration, pH, temperature, and saltion.

Cold and hot water extracted polysaccharides (CW-PNPs and HW-PNPs) were isolated from Pholiota nameko. The rheological properties of PNPs were investigated by steady shear and oscillatory rheological measurements. The PNPs exhibited typical non-Newtonian and shear-thinning behavior, which are affected by PNP concentration, temperature, pH value, salt ion, and concentration.