Cell-cell communications shape tumor microenvironment and predict clinical outcomes in clear cell renal carcinoma.

Background: Cell-cell communications of various cell populations within tumor microenvironment play an essential role in primary tumor growth, metastasis evolution, and immune escape. Nevertheless, comprehensive investigation of cell-cell communications in the ccRCC (Clear cell renal carcinoma) microenvironment and how this interplay affects prognosis still remains limited.

Methods: Intercellular communications were characterized by single-cell data.