Identification of Core Genes Shared by Endometrial Cancer and Ovarian Cancer Using an Integrated Approach.

Ovarian cancer (OC) is one of the most commonly diagnosed cancers among women. Moreover, Endometrial cancer (EC) is a usual genital tract cancer in females; however, the hub genes and molecular pathways shared by these two cancers have not been surveyed yet. So, this study aimed to identify the common candidate genes or biomarkers and molecular pathways in OC and EC.

DPP6 and MFAP5 are associated with immune infiltration as diagnostic biomarkers in distinguishing uterine leiomyosarcoma from leiomyoma.

Objective: Uterine leiomyosarcoma (ULMS) is the most common subtype of uterine sarcoma and is difficult to discern from uterine leiomyoma (ULM) preoperatively. The aim of the study was to determine the potential and significance of immunerelated diagnostic biomarkers in distinguishing ULMS from ULM.

Methods: Two public gene expression profiles (GSE36610 and GSE64763) from the GEO datasets containing ULMS and ULM samples were downloaded.

Protective effects of upregulated gene against the apoptosis of human retinal pigment epithelial cells .

Aim: To investigate the protective effect of heme oxygenase-1 (HO-1) against HO-induced apoptosis in human ARPE-19 cells.

Methods: The lentiviral vector expressing HO-1 was prepared and transfected into apoptotic ARPE-19 cells induced by HO. Functional experiments including cell counting kit-8 (CCK-8) assay, flow cytometry (FCM) and mitochondrial membrane potential assay were conducted.

[Genetic diagnosis of thalassemia mutations with free fetal DNA in pregnant plasma].

This research was aimed to develop a simple, rapid, accurate and non-invasive method by means of flow-through hybridization technology, which can be used for molecular screening and early prenatal diagnosis for detecting common β-thalassemias mutational genotypes. By using PCR technology combined with flow-through hybridization of low-density gene chip technology, the 6 sets of PCR primer single tube multiplex PCR system and 29 types of DNA probes were designed, then the mutational thalassemias in foetus DNA was rapidly detected in total of 60 anaemia pregnant women plasma. The results showed that 4 cases with deletional α-thalassemias, 3 cases with β-thalassemias, 1 case with mixed type of α & β-thalassemias were detected in foetus DNA of 60 pregnant women plasmas.