Publications by authors named "Liu-Qing Chen"

Objective: To explore the clinical characteristics, treatment, and prognosis of patients with blastic plasmacytoid dendritic cell neoplasm(BPDCN).

Methods: Clinical data of 5 patients diagnosed with BPDCN in Wuhan First Hospital and Wuhan Tongji Hospital from June 2016 to November 2021 were retrospectively analyzed.

Results: Among the 5 patients, 3 were male and 2 were female, with a median age of 28(10-52) years old.

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Background: Hemoporfin-mediated photodynamic therapy (PDT) is an effective treatment for port-wine stains (PWS), and pain is the main adverse effect of this therapy. General anesthesia is commonly used for pain management during PDT, but the effect of general anesthetics on the subsequent treatment efficacy of PDT in PWS has not been reported.

Objectives: To assess the use of general anesthesia combined with PDT compared with PDT alone in 207 PWS patients, and to provide further safety and efficacy data on this combined therapy.

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Article Synopsis
  • Port-wine stains (PWSs) are congenital disorders linked to various genetic mutations affecting blood vessel development, but the specific mutations remain largely unclear.
  • Researchers utilized whole-genome sequencing (WGS) on DNA from four patients to identify genetic variations, uncovering a known GNAQ mutation in one and six novel mutations across three genes in the others.
  • Additionally, two of the newly identified mutations showed frequencies of 60% and 40% in tests on five other sporadic PWS patients, emphasizing the genetic diversity in PWS and paving the way for potential clinical applications.
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The understanding of the hydrolysis mechanism of lanthanide ions is limited by their elusive coordination configuration and undeveloped technology. A potential solution by high-resolution mass spectroscopy studies is hindered by the lack of a stable model under electrospray ionization (ESI) conditions and the complexity of the spectra. Herein, it is demonstrated that diketonate ligands can efficiently stabilize the hydrolyzed intermediate cluster of Ln under ESI conditions, and an effective mass difference fingerprint of isomorphism (MDFI) method is proposed, which can allow the determination of the nuclearity-number of the species without depth resolution.

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Multifunctional lanthanide coordination polymers (CPs) have the advantages of acting in two or more fields simultaneously. Herein, two single lanthanide CPs, formulated as LnL(D/L-Hlac)(HO)·0.5HO (Ln = Eu (), Tb (); HL = 4,4'-(pyridine-3,5-diyl)dibenzoic acid) and their doped lanthanide analogue TbEuL(D/L-Hlac)(HO)·0.

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Two lanthanide-titanium oxo clusters (LTOCs), formulated as [EuTi(μ-O)(μ-OH)(CHO)(Ac)(CHOH)(tbba)]·CHOH () and [EuTi(μ-O)(μ-OH)(μ-OCH)(μ-OCH)(HO)(CHOH)(tbba)]·Htbba·10HO (), were synthesized through the solvothermal reaction of 4--butylbenzoate ligand, Eu(Ac)·3HO, and Ti(OPr) in methanol. Single-crystal structural analysis reveals that crystallized in the orthorhombic space group 2, and crystallized in the triclinic space group 1. Structurally, the core of can be viewed as a coplanar unit of [EuTi(μ-O)(μ-OH)] formed through each μ-O and μ-OH bridging one Ti and two Eu ions, while that of can be viewed as two units of [EuTi(μ-O)(μ-O)(μ-OCH)(CHOH)] and [EuTi(μ-O)(μ-OH)(μ-OCH)(HO)(CHOH)] connected through four μ-O units from the [EuTi(μ-O)(μ-O)(μ-OCH)(CHOH)] unit to respectively coordinate two Eu and two Ti ions from the [EuTi(μ-O)(μ-OH)(μ-OCH)(HO)(CHOH)] unit.

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Based on the anion template and chiral ligand inducting role, two series of high-nuclearity 3 d-4 f heterometallic clusters with formulas [NO@LnCu(μ-OH)(μ-OH)(OAc)( R/ S-L)(HO)](NO)· x(HO) (Ln = Dy, x = 30 for 1a( R-L) and 1b( S-L); Ln = Tb, x = 40 for 2a( R-L) and 2b( S-L)) and (EtNH)[LnCu(μ-OH)(μ-Cl)Cl( R/ S-L)]Cl· x(HO) (Ln = Dy, x = 28 for 3a( R-L) and 3b( S-L); Ln = Tb, x = 33 for 4a ( R-L) and 4b( S-L); HL = ( R/ S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid), have been synthesized and characterized. Structural analysis reveals that the metal skeleton of compounds 1 and 2 display a LnCu octahedral inner core encapsulated by six outer Cu units. In the LnCu octahedron, 6 Ln ions located at the six vertices and 12 inner Cu ions located at the 12 edges of octahedron, and one NO locates in the center of the octahedron.

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Endoglycoceramidases (EGCases) specifically hydrolyze the glycosidic linkage between the oligosaccharide and the ceramide moieties of various glycosphingolipids, and they have received substantial attention in the emerging field of glycosphingolipidology. However, the mechanism regulating the strict substrate specificity of these GH5 glycosidases has not been identified. In this study, we report a novel EGCase I from 103S (103S_EGCase I) with remarkably broad substrate specificity.

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Bis(2-(4-methyl-2-hydroxyphenyl)benzothiazolate) zinc(Zn(4-MeBTZ)2) was synthesized. Its molecular structure was confirmed by single-crystal x-ray diffraction. Single-crystal data are as follows: space group triclinic, P-1; a = 8.

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Tris (2-methyl-8-hydroxyquinoline) aluminum (AlMeq3) was synthesized and purified by vacuum sublimation. The structure of the complex was characterized by 1H NMR, FTIR spectra and elemental analysis techniques. AlMeq3 consists of three 2-methyl-8-hydroxyquinoline ligands and one aluminum atom.

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A Schiff base organic metal complex, Bis(salicylidene)-1,2-phenylenediam-ine Zinc(II) with high purity, was synthesized and purified by vacuum sublimation. Its structure, thermal stability and energy band structure were investigated by element analysis, FTIR spectra, TG-DTA curve, UV-Vis absorption spectra, fluorescece emission spectra and PL spectra. Experimental results showed that the complex is a thermally stable, polycrystalline material, with glass temperature and decomposition temperature being 183 and 449 degrees C, respectively.

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