Publications by authors named "Liu-Dong Wang"

Objective: To investigate the effect of notch signaling on differentiation of rat bone marrow mesenchymal stem cells (MSCs) into neurons induced by fasudil hydrochloride.

Methods: The experiments were divided into non-transfected group, transfected group (transfected with Rn-Notch1-siRNA), positive control group (transfected with Rn-MAPK-1 Control siRNA) and negative control group (transfected with negative control siRNA). Fasudil hydrochloride induced MSCs differentiating into neurons.

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Objective: To study the effects of Down syndrome cellular adhesion molecule (DSCAM) on differentiation of rat marrow mesenchymal stem cells (MSCs) into neurons in vitro.

Methods: MSCs from Sprague-Dawley rats were induced into neurons by baicalin. The expression of DSCAM before and after induction was evaluated by immunocytochemical staining and Western blot assay.

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Synopsis of recent research by authors named "Liu-Dong Wang"

  • - Liu-Dong Wang's research primarily focuses on the differentiation of rat bone marrow mesenchymal stem cells (MSCs) into neurons, investigating the underlying molecular mechanisms and influences of specific signaling pathways and cellular adhesion molecules.
  • - Key findings highlight the role of notch signaling and Down syndrome cellular adhesion molecule (DSCAM) in neuron differentiation induced by pharmacological agents like fasudil hydrochloride and baicalin, suggesting potential therapeutic avenues for neurodegenerative conditions.
  • - The methodologies utilized include transfection techniques and various assays such as immunocytochemical staining and Western blot, indicating a robust experimental approach to validating the molecular changes during stem cell differentiation in vitro.