Publications by authors named "Liu-Bin Li"
The construction of all-carbon quaternary centers, especially those containing an alkyne-substituted framework, represents an important challenge in organic synthesis. Here we present a novel Fe-catalyzed selective formal insertion of diazo compounds into C(sp)-C(sp) bonds of propargyl alcohols under mild conditions that enables the streamlined construction of alkyne-substituted all-carbon quaternary centers. This unique strategy starts with in situ generation of an ester group in the presence of carboxylic acids, followed by insertion of metal-carbene into C(sp)-C(sp) bonds, which may open up a new reaction mode for exploring metal-carbene insertion into acyclic C-C bonds.
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- - The study aimed to create uniform-sized microspheres loaded with silybin using a stainless steel membrane emulsification technique.
- - Microspheres were successfully prepared with an average diameter of about 4.96 micrometers, a smooth surface, and showed a drug loading of approximately 23.6% with an entrapment efficiency of about 55%.
- - The research concludes that stainless steel membrane emulsification is effective for producing silybin-loaded PLGA microspheres, indicating good potential for further application in drug delivery systems.