Crucial Role of the Ca/CN Signaling Pathway in the Antifungal Activity of Seselin against .

causes gray mold in many fruit and vegetable crops. We previously found that Seselin (SL) displayed antifungal activity against (EC = 6.1 μg·mL), and this study investigated the effects of Ca and the Ca/CN signaling pathway on its antifungal activity against .

Crucial role of Ca /CN signalling pathway in the antifungal activity of disenecioyl-cis-khellactone against Botrytis cinerea.

Background: Botrytis cinerea causes grey mould and is one of the most destructive fungal pathogens affecting important fruit and vegetable crops. In preliminary studies, we found that disenecioyl-cis-khellactone (DK) had strong antifungal activity against several fungi species including B. cinerea [half maximal effective concentration (EC ) = 11.

The Effects of Different Catalysts, Substituted Aromatic Aldehydes on One-Pot Three-Component Biginelli Reaction.

Aim And Objective: The Biginelli reaction, first reported in 1893, is one great example of the important multicomponent reactions reported from 1893. Under the same conditions, the influence of the common catalysts on the yield of the Biginelli reaction was investigated.

Materials And Method: To a round-bottom flask equipped with a spherical condenser were added 1,3- dicarbonyl compound (1.

Evaluation of antifungal activities and structure-activity relationships of coumarin derivatives.

Background: Osthol is a natural coumarin and lead compound that has been developed into commercial fungicides in China. Natural coumarins comprise five major subtypes: simple coumarins, linear furanocoumarins, angular furanocoumarins, linear pyranocoumarins and angular pyranocoumarins. Studies pertaining to the antifungal activities of linear pyranocoumarins are few, and no reports exist for the antifungal activities of angular pyranocoumarins.

Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening.

Targeting acetylcholinesterase (AChE) using small molecule inhibitors is considered to be the most successful therapeutic strategy in the treatment of Alzheimer's disease (AD). Herein we present a shape-based virtual screening to identify new cores for the designing of AChE inhibitors. Ten active hits are identified and the most active hit, 5169-0032 and T5369186, showed comparable AChE inhibitory activity to tacrine.

TLR4 polymorphisms associated with developing gastric pre-cancer lesions in a Chinese Han population.

Helicobacter pylori infection is a risk factor for gastric cancer. In addition, toll-like receptor 4 (TLR4) plays a fundamental role in pathogen recognition and activation of innate immunity. This study investigated the association of TLR4 polymorphisms with a risk of intestinal metaplasia (IM) and intraepithelial neoplasia (IN) in a Chinese Han population.

Vagal afferents mediate antinociception of estrogen in a rat model of visceral pain: the involvement of intestinal mucosal mast cells and 5-hydroxytryptamine 3 signaling.

Unlabelled: Estrogen reportedly facilitates visceral nociception at the spinal or supraspinal level. The present study was aimed to investigate whether estrogen modulates visceral pain through the vagal pathway. Ovariectomized rats received estradiol, which was administered subcutaneously (to act through both the vagal and spinal pathways) or intraduodenally (to preferentially act through the vagal pathway).

[Anatomical study of improved lateral arm free flap].

Objective: To study the anatomy and preparation methods of an improved lateral arm free flap (LAFF) for the future clinical application.

Methods: Twenty-two adult upper extremities from cadavers after injected with red latex through common carotid arteries were used. The course, branches, distribution and variations of the blood vessels and nerves of the improved LAFF were observed.

Expression of NEDD9 in pancreatic ductal adenocarcinoma and its clinical significance.

The aim of this study was to investigate the expression and prognostic significance of NEDD9 in pancreatic ductal adenocarcinoma (PDA). Expressional levels of NEDD9 mRNA and protein in paired pancreatic cancer lesions and adjacent noncancerous tissues were examined by quantitative real-time PCR and western blotting. NEDD9 expression was analyzed by immunohistochemistry in 106 patients with PDA.

Studies on chemical structure modification and structure-activity relationship of derivatives of gambogic acid at C(39).

The natural product gambogic acid exhibits high potency in inhibiting cancer cell lines. Rational medicinal modifications on gambogic acid will improve its physicochemical properties and drug-like characters. To investigate the structure-activity relationship of gambogic acid and also to find rational modification position on its chemical skeleton, we designed, synthesized, and characterized 16 derivatives of gambogic acid that were modified at C(39).

[The design of inferior rectus abdominis flap and its study of applied anatomy].

Objective: To describe the anatomy of inferior epigastric artery and its correlation with rectus abdominis muscle in order to provide anatomical basis for reconstruction of defect in the oral and maxillofacial region.

Methods: 10 Chinese adult specimens fixed by 10% formalin were simulated for the design of inferior rectus abdominis flap, and then observing, taking a photograph during the cadavers were being operated and measuring by image analysis software in the end.

Results: The original external diameters of inferior epigastric artery and length of its trunk were (2.

Anatomic measurement of wrist scaphoid and its clinical significance.

Objective: To provide anatomical basis for the internal fixation of scaphoid fractures.

Methods: The shape and vascular lake of 48 dry scaphoids and 36 wet scaphoids were observed.

Results: The data of dry bone group and wet bone group were as follows: the height of scaphoid tubercle were (11.

Applied anatomy of the lower cervical pedicle screw insertion.

Objective: To ascertain an accurate approach to inserting the pedicle screw into C3-C7 segments of the cervical vertebra.

Methods: Anatomic morphology of lateral mass and pedicle, and their anatomic relationship with the adjacent tissue were observed on C3-C7 segments of 25 adult embalmed cadavers (50 sides).

Results: 1) The inferior edge of the base of the posterior tubercle of the transverse process and the inferior edge of the pedicle were connected with each other on 25 adult embalmed cadavers (50 sides).

[Applied anatomy study on the reversed submental island flap].

Objective: To provide anatomic data for clinical use of reversed submental island flap in reconstruction of buccal and facial defects.

Methods: Twenty cadavers with 40 sides of head and neck which were fixed by formalin and perfused by red emulsion, 6 fresh cadavers which were perfused by coloring agent were dissected, observed and measured.

Results: The diameter of the submental artery, the superior lip artery and the inferior lip artery at their origins were respectively (1.