Objective: Myocardial injury has not been well characterized in traumatic brain injury (TBI). We aimed to assess the pooled incidence of myocardial injury defined by elevated cardiac troponin (cTn) after TBI and explore its association with in-hospital mortality.
Methods: We searched Medline, Embase, Cochrane Library, Scopus, and Web of Science from inception to 1 January 2024, for observational studies that assessed the incidence and/or associated in-hospital mortality of elevated cTn in adult TBI patients.
It is a great challenge for vehicles to satisfy the increasingly stringent emission regulations for pollutants and greenhouse gases. Throughout the history of the development of vehicle emission control technology, catalysts have always been in the core position of vehicle aftertreatment. Aiming to address the significant demand for synergistic control of pollutants and greenhouse gases from vehicles, this review provides a panoramic view of emission control technologies and key aftertreatment catalysts for vehicles using fossil fuels (gasoline, diesel, and natural gas) and carbon-neutral fuels (hydrogen, ammonia, and green alcohols).
View Article and Find Full Text PDFBackground: Gastric cancer (GC) is one of the deadly malignancies of the gastrointestinal tract. Research has confirmed the linkage of P2RX1 with immune cell activation and tumor progression. This project focused on the impact of P2RX1 level in neutrophils on the efficacy of immune checkpoint inhibitor (ICI) treatment in GC.
View Article and Find Full Text PDFClin Breast Cancer
November 2024
The deliberately origin mislabeling of sweet cherry causes significantly disruptions to market integrity and consumers' trust. In this study, 153 cherry samples from five provinces in China and the corresponding irrigation water and soil samples were collected. 5 stable isotope ratios (δC, δN, δH, δO, Sr/Sr) and 8 multi-element contents (Na, Mg, P, K, Ca, Fe, Zn, Se) of cherry were determined by EA-IRMS and ICP-MS to study isotopic fractionation and elemental enrichment mechanisms for origin traceability.
View Article and Find Full Text PDFInterleukin (IL)-33 is released following tissue damage, causing airway inflammation and remodelling via reduced IL-33 (IL-33)/serum stimulation-2 (ST2) and oxidised IL-33 (IL-33)/receptor for advanced glycation end products (RAGE)/epidermal growth factor receptor (EGFR) pathways. This study aimed to identify associations of IL-33 with clinical outcomes and pathological mechanisms during viral lower respiratory tract disease (LRTD). Ultra-sensitive immunoassays were developed to measure IL-33, IL-33 and IL-33/sST2 complexes in samples from patients hospitalised with COVID-19.
View Article and Find Full Text PDFPurpose: One of the primary causes of heat-induced compartment syndrome is the loss of elasticity of the body surface eschar itself, we have recently replaced escharotomy with conservative tangential excision in the treatment of compartment syndrome caused by heat and achieved good results.
Methods: Since 2019, our burn center has applied conservative tangential excision and heterogeneous dermal coverage technology for decompression treatment of 16 patients with thermal-induced compartment syndrome, involving 19 parts of the limbs and 5 parts of the chest and abdomen. All cases were treated with decompression under general anesthesia within 12-48 h after burn.
Vanadium-based oxide cathodes are promising energy-storage systems for aqueous zinc-ion batteries (AZIBs) because of their high energy density and safety, and low cost. However, their limited ion/electron transfer rates and rapid capacity decay pose challenges to their practical application. To overcome these limitations, VO nanoparticles are developed with surface oxygen vacancies integrated with N-doped carbon nanofibers (VO@NCNFs), using an electrospinning method combined with an in situ oxidation/reduction strategy.
View Article and Find Full Text PDFAs a common pollutant, cadmium (Cd) poses a serious threat to the growth and development of plants. Currently, there is no effective method to elucidate the protective mechanism of Cd in plant cells. For the first time, we designed a Cd fluorescent probe to observe the adsorption and sequestration of Cd in rice cell walls and vacuoles.
View Article and Find Full Text PDFThe catalytic conversion of CO to CO through hydrogenation has emerged as a promising strategy for CO utilization, given that CO serves as a valuable C1 platform compound for synthesizing liquid fuels and chemicals. However, the predominant formation of CH via deep hydrogenation over Ru-based catalysts poses challenges in achieving selective CO production. High reaction temperatures often lead to catalyst deactivation and changes in selectivity due to dynamic metal evolution or agglomeration, even with a classic strong metal-support interaction.
View Article and Find Full Text PDFThe red swamp crayfish (Procambarus clarkii) is the second most widely cultured crustacean globally. As a highly invasive species with a worldwide distribution, P. clarkii presents a substantial risk for the transmission of viral pathogens to native aquatic organisms.
View Article and Find Full Text PDFJ Synchrotron Radiat
January 2025
High-repetition-rate free-electron lasers impose stringent requirements on thermal deformations of optics in the beamline. The Shanghai HIgh-repetition-rate XFEL aNd Extreme light facility (SHINE) experiences high average thermal power and demands wavefront preservation. To effectively manage thermal deformation in the first reflection mirrors M1, we optimized the cooling length and position of the cooling groove with numerical calculations.
View Article and Find Full Text PDFElectrolyte chemistry regulation is a feasible and effective approach to achieving a stable electrode-electrolyte interface. How to realize such regulation and establish the relationship between the liquid-phase electrolyte environment and solid-phase electrode remains a significant challenge, especially in solid electrolyte interphase (SEI) for metal-ion batteries. In this work, solvent/anion steric hindrance is regarded as an essential factor in exploring the electrolyte chemistry regulation on forming ether-based K-dominated SEI interface through the cross-combination strategy.
View Article and Find Full Text PDFJ Hazard Mater
December 2024
Microplastics (MPs) are increasingly recognized as contaminants present in various environments and are widely acknowledged as potential hazards to the mammalian immune system. In our study of chimeric antigen receptor T cell (CAR-T) therapy, we observed the presence of MP in CAR-T cell products for the first time. It is worth exploring whether MP could enter CAR-T cells and how they might affect CAR-T cells' functionality.
View Article and Find Full Text PDFProbiotics hold great potential for treating metabolic diseases such as obesity. Given the complex and multifactorial nature of these diseases, research on probiotic combination with multiple targets has become popular. Here, we choose four obesity-related targets to perform high-throughput screening, including pancreatic lipase activity, bile salt hydrolase activity, glucagon-like peptide-1 secretion and adipocyte differentiation.
View Article and Find Full Text PDFMed Image Anal
January 2025
Medical images are an essential basis for radiologists to write radiology reports and greatly help subsequent clinical treatment. The task of generating automatic radiology reports aims to alleviate the burden of clinical doctors writing reports and has received increasing attention this year, becoming an important research hotspot. However, there are severe issues of visual and textual data bias and long text generation in the medical field.
View Article and Find Full Text PDFCutaneous immune-related adverse events (irAEs) of immunotherapies, such as anti-programmed cell death protein-1 (PD-1), suggest that immune checkpoint factors may contribute to the pathobiology of lichenoid interface dermatitis in immunotherapy-naïve patients. Our study aimed to describe innate and adaptive immune markers via immunohistochemical (IHC) staining of lichenoid interface dermatoses. We studied the staining patterns of PD-L1, STING, IL-36 gamma, CD8, PD-1, and LAG-3 in five interface dermatoses: oral lichen planus (LP) (n = 10), cutaneous LP (n = 10), chronic cutaneous lupus erythematosus (CLE) (n = 11), erythema multiforme (EM) (n = 11), and toxic epidermal necrolysis (TEN) (n = 13), by immunohistochemistry (IHC) analysis.
View Article and Find Full Text PDFWeakly supervised semantic segmentation, based on image-level labels, abandons the pixel-level labels relied upon by traditional semantic segmentation algorithms. It only utilizes images as supervision information, thereby reducing the time cost and human resources required for marking pixel data. The prevailing approach in weakly supervised segmentation involves two-step method, introducing an additional network and numerous parameters, thereby complicating the model structure.
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