Immune cells mediated the causal relationship between the gut microbiota and anxiety disorders: A Mendelian randomization study.

Background: Studies have demonstrated that the gut microbiome-immune system-brain axis plays an important role in neurological disorders. Furthermore, recent studies have shown that the gut microbiota influences the occurrence and progression of anxiety disorders, with potential involvement of immune cells. We aimed to investigate the causal impact of gut microbiota on anxiety disorders and identify potential immune cell mediators.

A constitutive model for coal gangue coarse-grained subgrade filler incorporating particle breakage.

The accumulation and discharge amount of coal gangue are substantial, occupying significant land resources over time. Utilizing coal gangue as subgrade filler can generate notable economic and social benefits. Coal gangue coarse-grained soil (CGSF) was used to conduct a series of large-scale vibration compaction tests and large-scale triaxial tests.

A randomized, crossover trial of one night of oxygen therapy for obstructive sleep apnea in patients with fibrotic interstitial lung disease.

Background And Objective: There is no satisfactory treatment for obstructive sleep apnea (OSA) in patients with interstitial lung disease (ILD) because of poor tolerance of positive airway pressure (PAP) therapy. Supplemental oxygen therapy has been shown to reduce hypoxemia and is well tolerated in patients with ILD. However, little is known about the effect of nocturnal oxygen supplementation (NOS) on OSA in patients with ILD.

Seryl-tRNA synthetase inhibits Wnt signaling and breast cancer progression and metastasis.

Tumors require ample protein synthesis to grow, and aminoacyl-tRNA synthetases, as critical translation factors, are expected to support cancer progression. Unexpectedly, overexpression of seryl-tRNA synthetase (SerRS) suppresses primary tumor growth of breast cancer. However, the effects of SerRS on metastasis have not been studied.

Analysis of MRI imaging characteristics in 10 cases of adult granulosa cell tumor with normal estrogen levels.

Objective: This study investigates the MRI characteristics of primary and metastatic adult granulosa cell tumor with normal estrogen levels (AGCT-NEL) to enhance clinical understanding and diagnostic accuracy of this disease.

Methods: We collected clinical data from 10 patients with AGCT-NEL, confirmed by pathology, treated at our hospital from January 2016 to January 2024. We retrospectively analyzed the MRI features of primary and metastatic lesions from aspects such as shape, edge characteristics, MRI signal, and enhancement features.

Rapid and Visual Detection of Urinary Pathogens by Employing Bifunctional Deoxyribonucleic Acid Sensors and Aggregation of Gold Nanoparticles.

A simple, rapid, and visual approach is developed to perform diagnosis of urinary tract infection (UTI) and antimicrobial susceptibility testing (AST) by employing smart bifunctional DNA (bfDNA) sensors, exonuclease III, concatermers of CuO nanoparticles (CuONPs), and gold NPs (AuNPs) aggregation [AuNPs agglutination (AA)], namely, the bfDEC-AA method. The bfDNA sensors serve as probes for identifying 16S rRNA genes of bacterium or 18S rRNA of fungus and as mediators connecting the concatermers of CuONPs. The AA as a signal source is triggered by Cu(I)-catalyzed azide-alkyne cycloaddition click chemistry.

An improved Patlak-based Kparametric imaging approach for clinicalF-FDG total-body PET.

Objective: The objective is to generate reliable Ki parametric images from 18F-FDG total-body PET with clinically acceptable scan durations using Patlak and shallow machine learning algorithms, under conditions of limited computational and data resources.

Approach: We proposed a robust and fast algorithm named Patlak-KXD to generate Ki images from dynamic PET images with shortened scan durations. In the training phase, K-means is employed to generate a Ki-balanced training dataset.

Newcomers' perceptions of their experiences with oral health care in Canada and the United States.

Background: Recently, an increasing number of immigrants and asylum seekers and refugees (ASRs) have settled in both Canada and the United States. The poor oral health status prevalent among this population is a significant issue. Oral health professionals in both countries should understand newcomers' experiences with oral health care services to become more culturally competent.

Multifunctional hyaluronic acid ligand-assisted construction of CD44- and mitochondria-targeted self-assembled upconversion nanoparticles for enhanced photodynamic therapy.

Upconversion nanoparticles (UCNPs) have been used as a potential nanocarrier for photosensitizers (PSs), which have demonstrated a great deal of promise in achieving an effective photodynamic therapy (PDT) for deep-seated tumors. However, overcoming biological barriers to achieve mitochondria-targeted PDT remains a major challenge. Herein, CD44- and mitochondria-targeted photodynamic nanosystems were fabricated through the self-assembly of hyaluronic acid-conjugated-methoxy poly(ethylene glycol)-diethylenetriamine-grafted-(chlorin e6-dihydrolipoic acid-(3-carboxypropyl)triphenylphosphine bromide) polymeric ligands (HA-c-mPEG-Deta--(Ce6-DHLA-TPP)) and NaErF:Tm@NaYF core-shell UCNPs (termed CMPNs).

Long cycle life aqueous zinc-ion battery enabled by a ZIF-N protective layer with electron-withdrawing group and zincophilicity on the Zn anode.

Aqueous zinc-ion batteries (AZIBs) have garnered attention from researchers for their high theoretical capacity, safety, and low cost. However, the uncontrolled growth of zinc (Zn) dendrites and spontaneous corrosion reactions on the Zn anode significantly compromise the cycle life of AZIBs. This paper proposes the utilization of a novel zeolitic imidazole framework (ZIF-N) material with zincophilicity and hydrophilicity for modifying the Zn anode of AZIBs.

Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVID-19.

Background: Despite recent therapeutic advances, combating cancer resistance remains a formidable challenge. The 78-kilodalton glucose-regulated protein (GRP78), a key stress-inducible endoplasmic reticulum (ER) chaperone, plays a crucial role in both cancer cell survival and stress adaptation. GRP78 is also upregulated during SARS-CoV-2 infection and acts as a critical host factor.

Sustainable hydrochar as an efficient persulfate activator for cost-effective degradation of bisphenol A.

This study explored Mason pine-derived hydrochar (MPHC) as an effective adsorbent and persulfate (PS) activator for degrading bisphenol A (BPA). Increasing MPHC dosage from 0.25 to 2.

Prediction of concrete compressive strength using a Deepforest-based model.

Concrete compressive strength testing is crucial for construction quality control. The traditional methods are both time-consuming and labor-intensive, while machine learning has been proven effective in predicting the compressive strength of concrete. However, current machine learning-based algorithms lack a thorough comparison among various models, and researchers have yet to identify the optimal predictor for concrete compressive strength.

Comparison of robotic-assisted total knee arthroplasty: an updated systematic review and meta-analysis.

This study was conducted to compare the changes in different clinical scores and imaging indexes of patients who underwent robot-assisted total knee arthroplasty (RA-TKA) and manual total knee arthroplasty (M-TKA). PubMed, Web of Science, Cochrane Library and Embase were searched according to PRISMA guidelines in June 2024. Search terms included "robot-assisted", "manual" and "total knee arthroplasty".

Remote Mountainous Area Inevitably Becomes Temporal Sink for Microplastics Driven by Atmospheric Transport.

Atmospheric transport drives the widespread distribution of microplastic (MP) in various ecosystems, posing a growing potential threat to environmental safety and human health. Understanding the source and fate of atmospheric MPs is thus crucial to constrain MP's widespread exposure. However, the source-sink dynamics of atmospheric MPs, especially in remote areas, are uncertain, and their transport routes have yet to be identified.

Tropism-shifted AAV-PHP.eB-mediated bFGF gene therapy promotes varied neurorestoration after ischemic stroke in mice.

AAV-PHP.eB is an artificial adeno-associated virus (AAV) that crosses the blood-brain barrier and targets neurons more efficiently than other AAVs when administered systematically. While AAV-PHP.

GRP78 inhibitor YUM70 upregulates 4E-BP1 and suppresses c-MYC expression and viability of oncogenic c-MYC tumors.

The 78-kDa glucose regulated protein (GRP78) commonly upregulated in a wide variety of tumors is an important prognostic marker and a promising target for suppressing tumorigenesis and treatment resistance. While GRP78 is well established as a major endoplasmic reticulum (ER) chaperone with anti-apoptotic properties and a master regulator of the unfolded protein response, its new role as a regulator of oncoprotein expression is just emerging. MYC is dysregulated in about 70 % of human cancers and is the most commonly activated oncoprotein.