Recognition of mild cognitive impairment in older adults using a polynomial regression model based on prefrontal cortex hemoglobin oxygenation.

Aim: This study employed a three-minute game-based intelligence test (GBIT) to create a hemoglobin polynomial regression model for early identification of mild cognitive impairment (MCI) in older adults.

Methods: 210 older adult participants were recruited from community centers in the central region of Taichung City. Working memory (WM) performance in older adults was assessed during GBIT, while hemoglobin responses were measured by near-infrared spectroscopy (NIRS).

TRAF-mediated regulation of immune and inflammatory responses.

The tumor necrosis factor (TNF) receptor-associated factor (TRAF) family consists of six mammalian members, and is shown to participate in signal transduction of a large number of receptor families including TNF receptor family (TNFR) and Toll-like receptors-interleukin-1 receptors (TLR-IL-1R) family. Upon receptor activation, TRAFs are directly or indirectly recruited to the intracellular domains of these receptors. They subsequently engage other signaling proteins to activate inhibitor of kappaB kinase (IKK) complex, TRAF family member-associated NF-kappaB activator (TANK)-binding kinase 1 (TBK1) and inducible I kappaB kinase (IKK-i) (also known as IKKepsilon), ultimately leading to activation of transcription factors such as NF-kappaB and interferon-regulatory factor (IRF) to induce immune and inflammatory responses.

Ankle eversion to inversion strength ratio and static balance control in the dominant and non-dominant limbs of young adults.

The purpose of this study was to: (1) compare unilateral ankle eversion to inversion strength ratio (E/I R) and static balance control in the dominant and non-dominant limbs and (2) determine the relationship between ankle E/I R and static balance control in the dominant and non-dominant limbs. Twenty-eight young, healthy adults without any physical training experience participated in this study. Ankle E/I R was measured by an isokinetic dynamometer at speeds of 30 degrees s(-1) and 120 degrees s(-1).